A comparison of the effect of two different dental local anaesthetic solutions on plasma potassium concentration

Meechan, J G; Rawlins, Matthew

doi:10.1038/sj.bdj.4806239

Cited by 14 publications

(11 citation statements)

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“…3,4 Other studies in volunteers and in patients undergoing periodontal surgery where lower doses of epinephrine have been used have shown similar results. 6,9 The results of the present study confirm these earlier findings.…”

Section: Discussionsupporting

confidence: 57%

“…2 Studies investigating the haemodynamic effects of epinephrine-containing and epinephrine-free local anaesthetics in healthy volunteers and patients have shown little effect on cardiovascular function. [3][4][5][6] However transplanted hearts are supersensitive to circulating catecholamines. 7,8 Therefore, cardiac transplant recipients receiving catecholamines for dental treatment may react differently from healthy patients.…”

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confidence: 99%

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Effects of dental local anaesthetics in cardiac transplant recipients

Meechan¹,

Parry

Rattray

et al. 2002

Br Dent J

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Section: Discussionsupporting

confidence: 57%

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confidence: 99%

Effects of dental local anaesthetics in cardiac transplant recipients

Meechan¹,

Parry

Rattray

et al. 2002

Br Dent J

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“…The systemic effects of adrenaline administered during dental local anaesthesia have been the subject of many studies [1][2][3], though previous conclusions regarding safety and efficacy were based upon incomplete understanding, bias, and limited scientific and clinical data [4]. Relative to haemodynamic effects of adrenaline in local anaesthesia, little work has been carried out on the metabolic changes that the increase in circulating adrenaline might produce.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Akinmoladun

Okoje

Akinosun

et al. 2012

J. Maxillofac. Oral Surg.

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Introduction The systemic effects of adrenaline administered during dental local anesthesia have been the subject of many studies. The purpose of this study was to investigate the haemodynamic and metabolic effects attributable to adrenaline injected during local anesthesia in dental extraction patients. Methods Apparently medically fit patients were included and randomized into two groups. Participants had breakfast before coming in for tooth extraction. The weight, height, blood pressure and pulse rate were measured and blood sample taken before administration of local anaesthetic injections. Blood pressure, pulse and blood sample were again taken at 15 and 30 min. Results While the adrenaline group showed a modest increase between pre-and post-drug administration states, the control group showed no difference in median systolic blood pressures. Both groups showed a slight increase in diastolic blood pressure observed between pre-and postdrug administration states. Also both groups showed no significant difference in median pulse rate throughout. Although blood glucose values were widely dispersed in the pre-drug administration state in both groups, the control group showed no difference in median values throughout. However, a modest increase was observed in the adrenaline group between pre-and post-drug administration states, which persisted beyond 30 min. Conclusion The patients treated with local anesthesia with adrenaline showed a response similar to that observed in the control group.

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“…3,4 Importantly this study compared two vasoconstrictorcontaining solutions which are routinely used in the United Kingdom, thus mimicking accepted clinical practice. Advice exists concerning reduction of the dose of epinephrine in dental local anaesthetics for patients with cardiac disease.…”

Section: Discussionmentioning

confidence: 99%