2014
DOI: 10.1016/j.ijpharm.2014.09.010
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A comparison of the effect of temperature and moisture on the solid dispersions: Aging and crystallization

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Cited by 37 publications
(19 citation statements)
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“…28 Unfortunately, the poor physical stability and low drug loading (,20%) of SD have severely limited the widespread application of this technology. 29 Combinations of NCs and SD technology may be a very interesting strategy for solidification of NC suspensions. In this work, to enhance drug loading and redispersibility of NCs, an NC-based SD (NC-SD) was developed by dispersing NCs into special matrix formers, which was expected to have dual advantages of NCs and SD.…”
Section: Introductionmentioning
confidence: 99%
“…28 Unfortunately, the poor physical stability and low drug loading (,20%) of SD have severely limited the widespread application of this technology. 29 Combinations of NCs and SD technology may be a very interesting strategy for solidification of NC suspensions. In this work, to enhance drug loading and redispersibility of NCs, an NC-based SD (NC-SD) was developed by dispersing NCs into special matrix formers, which was expected to have dual advantages of NCs and SD.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly the results showed rapid release rates for all CRC/SOL formulations with 56 -96% release within 1hr. SOL was used a drug carrier due to its amphiphilic nature and proven capacity to increase the solubility and bioavailability of water insoluble drugs by acting as solubilizer (Maniruzzaman et al, 2013;Tian et al, 2014). In our case SOL demonstrated increased solubilisation capacity especially for the CRC/SOL (1:2) ratio where 96% of the drug is release after 1hr.…”
Section: Resultsmentioning
confidence: 68%
“…Pada proses penuaan fisik, terjadi penurunan energi bebas permukaan partikel obat yang dapat memberikan efek yaitu penurunan disolusi dari dispersi padat meskipun kristalinitas obatnya tidak berubah. Hal ini disebabkan karena tingginya energi bebas permukaan pada dispersi padat menyebabkan stabilitasnya menjadi rendah dan cenderung mengalami aglomerasi untuk menurunkan energi bebas permukaan dengan mengurangi luas permukaannya 29,30 . Meningkatnya ukuran molekul obat akibat aglomerasi dapat menjadi salah satu penyebab turunnya laju disolusi.…”
Section: Diskusiunclassified