A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers

Abstract

Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three-way crossover design with 1 week wash-out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post-administration a battery of performance tests was administered which included a digit-matching paradigm and a reaction test separating recognition and motor time. In contrast to maprotiline, lofepramine did not impair speed and accuracy of cognitive performance.