A Comparison of the Deposition Patterns of Different Nasal Spray Formulations Using a Nasal Cast

Pu, Yu; Goodey, Adrian; Fang, Xiuhua; Jacob, Kuriakose

doi:10.1080/02786826.2014.931566

Cited by 54 publications

(34 citation statements)

References 15 publications

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“…Other experimental studies include [9] that found greater anterior deposition in children (12 year old model) leading to decreased effectiveness; Pu et al [10] investigated the effect of spray formulation (e.g. viscosity) on deposition patterns in a nasal cavity cast; Warken et al [11] found the optimum administration angle for nasal sprays applied to ten 3D-printed nasal cavity replicas, and showed that it could increase deposition in the main nasal passage.…”

Section: Introductionmentioning

confidence: 99%

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions

et al. 2019

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Deposition of polydisperse particles representing nasal spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial spray conditions, including spray cone angle, insertion angle, and initial velocity. Since nasal spray atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter ( Dv 50). Particle deposition in the anterior region was approximately 80% when Dv 50 > 50μm, and this decreased to 45% as Dv 50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site.

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Section: Introductionmentioning

confidence: 99%

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions

et al. 2019

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“…Very fast dripping of the formulation can make it flow outward from the nasal cavity (at the entrance to the nose) or flow rapidly towards the throat, which may result in a bad taste for the patient (Pu et al, 2014). This will depend on the nasal mucus state and the viscosity of the formulation.…”

Section: Evaluation Of the Dripping With Simulated Nasal Mucusmentioning

confidence: 99%

“…inhalation during administration, closing a nostril, etc.). Nasal casts were used by Pu et al to study the influence of L. Salade, et al International Journal of Pharmaceutics 561 (2019) 47-65 increasing the viscosity by adding microcrystalline cellulose or hydroxypropyl methylcellulose to their nasal liquid sprays (Pu et al, 2014). It was shown that the incorporation of microcrystalline cellulose (1 and 2% w/v) allowed dripping of the formulation at the front of the nose to be decreased while avoiding strong modifications of the deposition pattern.…”

Section: Deposition Studies In Nasal Cavities Using a Nasal Castmentioning

confidence: 99%

“…For the spray pattern, the tip device-apparatus distance is also crucial and should be made at two distinct distances, between 3 and 7 cm (Pu et al, 2014;Chen et al, 2015). The technique to evaluate the pattern of the spray can be an impaction-or a non-impaction-based method.…”

Section: Assessment Of the Plume Geometry And Spray Patternmentioning

confidence: 99%

“…Such techniques were used to evaluate the effect of a viscosity enhancer on the plume morphology (e.g. to increase the residence time or limit sedimentation during a suspension administration) (Pu et al, 2014;Pennington et al, 2008). It was shown that an increase in the viscosity led to the production of larger particles or droplets in the aerosol, which remained in a smaller spray area and had a thinner plume ( Fig.…”

Section: Assessment Of the Plume Geometry And Spray Patternmentioning

confidence: 99%

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How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

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Wauthoz

Goole

et al. 2019

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Nasal delivery offers many benefits over other conventional routes of delivery (e.g. oral or intravenous administration). Benefits include, among others, a fast onset of action, non-invasiveness and direct access to the central nervous system. The nasal cavity is not only limited to local application (e.g. rhinosinusitis) but can also provide direct access to other sites in the body (e.g. the central nervous system or systemic circulation). However, both the anatomy and the physiology of the nose impose their own limitations, such as a small volume for delivery or rapid mucociliary clearance. To meet nasal-specific criteria, the formulator has to complete a plethora of tests, in vitro and ex vivo, to assess the efficacy and tolerance of a new drug-delivery system. Moreover, depending on the desired therapeutic effect, the delivery of the drug should target a specific pathway that could potentially be achieved through a modified release of this drug. Therefore, this review focuses on specific techniques that should be performed when a nasal formulation is developed. The review covers both the tests recommended by regulatory agencies (e.g. the Food and Drug Administration) and other complementary experiments frequently performed in the field.

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2023

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A Comparison of the Deposition Patterns of Different Nasal Spray Formulations Using a Nasal Cast

Cited by 54 publications

References 15 publications

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

Intranasal and Inhaled Vaccines

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