A comparison of the cytogenetic response to asbestos and glass fibre in Chinese hamster and human cell lines

Sincock, A. M.; Delhanty, Joy D. A.; Casey, G.

doi:10.1016/0165-1218(82)90157-4

Cited by 51 publications

(20 citation statements)

References 10 publications

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“…In contrast, CHO cells exposed under this same regime exhibited numerous chromosomal changes (35), a result in concordance with earlier studies (30). Both CHO and human cell lines are inhibited to a similar extent with respect to rate of growth by these fiber preparations (35).…”

supporting

confidence: 73%

“…Since both the cell type and fiber type were different in the two human cell studies in question (34,35) it is, at present, not possible to discern the reason for the discrepancy. In one study, asbestos fibers appeared to produce SCEs in rodent cells (28), although two other investigations that reach the opposite conclusion have been reported (26,29).…”

mentioning

confidence: 63%

“…Thus, while it is clear that asbestos fibers are clastogenic to cultured rodent cells (25,(29)(30)(31)33), there is contradictory evidence with respect to human cells (34,35). Since both the cell type and fiber type were different in the two human cell studies in question (34,35) it is, at present, not possible to discern the reason for the discrepancy.…”

mentioning

confidence: 64%

“…At 72 hr, chromatid breaks were the most frequent change noted and the number of numerical alterations were lower than at 48 hr (34). In contrast, a comprehensive study by Sincock et al (35) showed that neither cultured human lymphoblasts nor human fibroblasts exhibited chromosomal aberrations when exposed to either UICC crocidolite, SFA chrysotile, or glass fibers (10 ,ug/mL to 100 ,ug/mL, 48-72 hr). In contrast, CHO cells exposed under this same regime exhibited numerous chromosomal changes (35), a result in concordance with earlier studies (30).…”

mentioning

confidence: 79%

“…In contrast, a comprehensive study by Sincock et al (35) showed that neither cultured human lymphoblasts nor human fibroblasts exhibited chromosomal aberrations when exposed to either UICC crocidolite, SFA chrysotile, or glass fibers (10 ,ug/mL to 100 ,ug/mL, 48-72 hr). In contrast, CHO cells exposed under this same regime exhibited numerous chromosomal changes (35), a result in concordance with earlier studies (30). Both CHO and human cell lines are inhibited to a similar extent with respect to rate of growth by these fiber preparations (35).…”

mentioning

confidence: 79%

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In Vitro Assessment of Asbestos Genotoxicity

Daniel¹

1983

Environmental Health Perspectives

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Asbestos fibers are highly cytotoxic to cultured mammalian cells and produce chromosomal aberrations in several rodent cell types. There is some uncertainty in the literature as to whether these fibers are clastogenic to cultured human cells. Asbestos fibers do not produce either DNA damage or back mutations in prokaryotic assay systems, and they do not appear to cause DNA strand breaks in either rodent or human cels. The evidence that these fibers can produce either forward mutation or neoplastic transformation of mammalian cells is weak. Asbestos fibers are clearly oncogenic to humans and animals, but, except for clastogenic effects in rodent cells, there is little evidence for genotoxicity of fibers. It is reasonable to expect, therefore, that these materials may be oncogenic by virtue of mechanisms rather than as tumor initiators.

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supporting

confidence: 73%

mentioning

confidence: 63%

mentioning

confidence: 64%

mentioning

confidence: 79%

mentioning

confidence: 79%

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In Vitro Assessment of Asbestos Genotoxicity

Daniel¹

1983

Environmental Health Perspectives

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Man‐Made Mineral Fibers

Singh¹,

Coffman²

2001

Patty's Industrial Hygiene

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Concerns about the adverse health effects of exposure to asbestos have prompted widespread removal of asbestos‐containing materials, resulting in the increased use of substitutes composed of both naturally occurring and synthetic materials. Man‐made mineral fiber asbestos substitutes are mineral fibrous materials such as fibrous glass, rock wool, slag wool, and refractory (ceramic) fibers. Because of the similarity of the chemical composition and morphology of these substitute fibrous materials to those of asbestos, serious questions have been raised about their health implications. In particular, there is growing concern whether such substitutes pose a carcinogenic risk similar to that of asbestos. These health concerns are even more pronounced considering that man‐made mineral fibers (MMMF) have found wide applications in commerce, in addition to their use as asbestos substitutes in the building industry.

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Man‐Made Mineral Fibers

Singh¹,

Wagner²

2011

Patty's Industrial Hygiene

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Man‐made mineral fiber (MMMF) asbestos substitutes are mineral fibrous materials such as fibrous glass, rock wool, slag wool, and refractory (ceramic) fibers. It has been reported that the chemical composition and morphology of these substitute fibrous materials are similar to those of asbestos and, therefore, serious questions have been raised about their health hazards. The man‐made mineral fibers have found wide applications in commerce and in the building industry. Evidence from epidemiological studies have shown that exposure to MMMF has moderately increased mortality rates and much less carcinogenic risk when compared to asbestos. It is prudent for industrial hygienists to treat these materials with the same precautions as asbestos and minimize the exposure among workers.

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A comparison of the cytogenetic response to asbestos and glass fibre in Chinese hamster and human cell lines

Cited by 51 publications

References 10 publications

In Vitro Assessment of Asbestos Genotoxicity

In Vitro Assessment of Asbestos Genotoxicity

Man‐Made Mineral Fibers

Man‐Made Mineral Fibers

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