A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

Ang, Tiing-Leong; Fock, Kwong–Ming; Ng, Tay-Meng; Teo, Eng–Kiong; Chua, T P; Tan, Jessica

doi:10.3748/wjg.v11.i23.3558

Cited by 45 publications

(44 citation statements)

References 26 publications

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“…Other authors reported individuals with complicated reflux disease being older than patients with NERD+, although the latter were actually much the same age as the group with ERD, as in our population [14] . We also found no gender-related differences in our two patient groups despite the literature reporting a tendency to find more females among NERD patients than among cases of esophagitis [12,15,16] . In our study population, the presence of hiatal hernia was associated more frequently with a picture of reflux with esophagitis.…”

Section: General Considerations: Study Populationcontrasting

confidence: 54%

“…In particular, the fact that the mean age of the ERD group was similar to that of the NERD+ patients (around 50 years old in both cases) seems to contradict the claim that patients with- out esophagitis tend to be younger and can be expected to progress towards a picture of full-blown esophagitis as they grow older [12,13] . Other authors reported individuals with complicated reflux disease being older than patients with NERD+, although the latter were actually much the same age as the group with ERD, as in our population [14] .…”

Section: General Considerations: Study Populationmentioning

confidence: 62%

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Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern

Bresàdola¹

2011

WJGP

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AIM: To investigate differences in the physiopathological findings (manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring, esophageal manometry and upper endoscopy were retrospectively evaluated, assessing the reflux symptoms, manometric characteristics of the lower esophageal sphincter (LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study, patients had to have NERD or ERD and be found positive on pH monitoring (NERD+). Patients with Gastroesophageal reflux disease (GERD) complicated by stenosis, ulcers or Barrett's esophagus were ruled out.RESULTS: 214 patients were involved in the study, i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia (P = 0.02) and more acid reflux, both in terms of number of reflux episodes (P = 0.01) and as a percentage of the total time with a pH < 4 (P = 0.00), when upright (P = 0.007) and supine (P = 0.00). The NERD+ cases had more reflux episodes while upright (P = 0.02) and the ERD cases while supine (P = 0.01). The LES pressure was higher in cases of NERD+ (P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group (P >0.05). The NERD+ patients presented more often with atypical symptoms (P = 0.01). CONCLUSION:The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position (unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments.

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Section: General Considerations: Study Populationcontrasting

confidence: 54%

Section: General Considerations: Study Populationmentioning

confidence: 62%

Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern

Bresàdola¹

2011

WJGP

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“…Table 2 shows a summary of four studies that reported the prevalence of NERD among patients with GERD symptoms presenting to upper endoscopy [5,6,7,8]. The reported prevalence ranged between 36.7 and 86.6%.…”

Section: Prevalence Of Nerdmentioning

confidence: 99%

Epidemiology of Non-Erosive Reflux Disease

El–Serag¹

2008

Digestion

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Non-erosive reflux disease (NERD) is a relatively new entity, the definition of which has been evolving and involves the use of symptoms, endoscopy, and objective evidence of reflux or reflux-related damage. The closest entity to NERD that is examined by available epidemiologic studies is defined by the presence of gastroesophageal reflux disease (GERD) symptoms in the absence of esophageal erosions or Barrett’s esophagus. In this review, I identified two population-based studies, one non-community study, and several endoscopy-based studies that provided information on several aspects of NERD. Most of GERD is NERD (50–85%), and therefore one can estimate 11–12% of the general population and considerably higher proportions of patients presenting to endoscopy (37–87%) may have NERD. Risk factors for NERD including absence of hiatus hernia, low BMI, and presence of Helicobacter pylori indicate that it is a ‘milder’ part of the GERD spectrum. Other associations of NERD include younger age, female sex, and psychological comorbidities that resemble those of functional gut disorders. The temporal trends in NERD are unclear, and are probably increasing because GERD symptom prevalence has increased.

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“…7 In daily practice, while GERD is often established as a non-severe case, it can be a serious disease with very high rate of medical and non-medical complications including Barrett's esophagus, malignancy, socio economic burden, and declined quality of life. 8 In the current standard, ambulatory esophageal pH monitoring remains unsatisfying as a gold standard so that the patients' medical history with/without endoscopic examination still plays a major role in the diagnosis. 9 GERD-questionnaire (GERDQ) includes reference questions comprised of typical and atypical symptoms of the disease for GERD-suspected patients and it is a simple diagnostic tool to be used in primary health care.…”

mentioning

confidence: 99%

“…Adapun lama DM,[2][3][4][5][6][7][8][9][10][11][12][13] p = 0,976), obesitas (37% vs 38%, p = 0,897), usia (53,2 ± 10,5 vs 54,7 ± 9,3, p = 0,481) …”

mentioning

confidence: 99%

Gastro-esophageal reflux disease among type-2 diabetes mellitus patients in a rural area

et al. 2015

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ABSTRAK p = 0,048). Adapun lama DM,[2][3][4][5][6][7][8][9][10][11][12][13] p = 0,976), obesitas (37% vs 38%, p = 0,897), usia (53,2 ± 10,5 vs 54,7 ± 9,3, p = 0,481) ABSTRACTBackground: One of the most neglected complications of diabetes mellitus (DM) is gastro-esophageal reflux disease (GERD) which arises from autonomic neuropathy and diabetic gastropathy related to the extent of DM. This study was done to find prevalence of GERD in DM patients with GERD-questionnaire (GERDQ), dietary factor proportion, and their association with other GERD risk factor in rural area.Methods: This cross sectional study was conducted in Puskesmas Pelaihari from August to September 2013. Subjects with DM aged ≥ 18 were selected consecutively from both newly and previously diagnosed patients with exclusion criteria: pregnancy, in proton-pump inhibitor therapy, and had other metabolic disease(s). DM was diagnosed with ADA criteria, while GERD was diagnosed in patients with score of ≥ 8 of Indonesian GERDQ.Results: There were 30 subjects (29.7%) with GERD among 101 patients with DM and dietary factors found in GERD patients were spicy diet (90%), high-fat food (90%), irritative beverages (87%), and irritative diet (23%). Only female gender was associated with GERD vs non-GERD in DM patients (87% vs 68%, p = 0.048). Meanwhile, duration of DM (2 [0-13] vs 2 [0-19], p = 0.976), obesity (37% vs 38%, p = 0.897), age (53.2±10.5 vs 54.7 ± 9.3, p = 0.481), and uncontrolled diabetes (90% vs 94%, p = 0.421) were not associated with the GERD among DM patients. Conclusion:Prevalence of GERD in DM is somewhat high in this study. Female group with DM needs to be screened for GERD as early as possible.

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A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

Abstract: The majority of patients who have typical symptoms of GERD have NERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with NERD were younger and had a higher prevalence of minor psychiatric morbidity.

Cited by 45 publications

References 26 publications

Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern

Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern

Epidemiology of Non-Erosive Reflux Disease

Gastro-esophageal reflux disease among type-2 diabetes mellitus patients in a rural area

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