A Comparison of the Circulating Endocan Levels between the Inflammatory and Malignant Diseases of the Same Organ: The Breast

Basım, Pelin; Arğun, Derya

doi:10.1080/08941939.2020.1792008

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…12,[16][17][18][19][20] High levels of endocan have also been detected at in many types of cancer, and it may show cancer activation and differentiate benign and malignant disease. [21][22][23][24] COVID-19 can be associated with micro and/or macro emboli and progresses with vascular inflammation. [25][26][27] In this context, our study was based on the hypothesis that endocan levels, which are a specific marker for vascular endothelial cells, will be elevated levels in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Görgün

Cindoruk

Özgen³

et al. 2021

Angiology

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We aimed to evaluate whether there was a relationship between endocan (human endothelial cell-specific molecule-1) levels and disease prognosis in patients who presented to the emergency department with coronavirus disease 2019 (COVID-19). A total of 60 patients with COVID-19 who were hospitalized from the emergency department to clinical wards and a control group consisting of healthy adult individuals (n = 28), were included in the study. The majority (93.3%) of the patients were discharged after recovery; 6.7% died. The median endocan value was 243.5 ng/mL in the patient group versus 201.5 ng/mL in the control group ( P = .002). The median endocan level was 240.5 ng/mL in those discharged with recovery and 558 ng/mL in those who died ( P = .001). There was no significant relationship in hospitalization duration, sex, tomography findings, and clinical outcomes. A 202 ng/mL serum endocan level had 86.7% sensitivity and 50% specificity for COVID-19. Serum endocan levels may be a useful biomarker both for the diagnosis of COVID-19 and to predict mortality.

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Section: Discussionmentioning

confidence: 99%

“…12,16–20 High levels of endocan have also been detected at in many types of cancer, and it may show cancer activation and differentiate benign and malignant disease. 21–24…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Görgün

Cindoruk

Özgen³

et al. 2021

Angiology

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“…Clinical investigations have consistently confirmed the abnormal expression of ESM1 in the blood or tumor tissues of patients with diverse cancers. Notably, elevated ESM1 levels have been observed in the circulatory systems of patients diagnosed with endometrial, cervical, renal, breast and lung cancer, multiple myeloma and hepatocellular carcinoma (19,(86)(87)(88)(89)(90). Furthermore, upregulated ESM1 expression has been detected in tumor samples collected from patients with pancreatic neuroendocrine tumors and glioblastoma (91,92).…”

Section: Value Of Esm1 As a Prognostic And Predictive Indicator Of Ca...mentioning

confidence: 99%

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)

Zhou,

Wang

et al. 2024

Oncol Lett

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Angiogenesis plays a crucial role in tumor growth and metastasis, and is heavily influenced by the tumor microenvironment (TME). Endothelial cell dysfunction is a key factor in tumor angiogenesis and is characterized by the aberrant expression of pro-angiogenic factors. Endothelial cell specific molecule-1 (ESM1), also known as endocan, is a marker of endothelial cell dysfunction. Although ESM1 is primarily expressed in normal endothelial cells, dysregulated ESM1 expression has been observed in human tumors and animal tumor models, and implicated in tumor growth, metastasis and angiogenesis. The precise role of ESM1 in tumor angiogenesis and its potential regulatory mechanisms are not yet conclusively defined. However, the aim of the present review was to explore the involvement of ESM1 in the process of tumor angiogenesis in the TME and the characteristics of neovascularization. In addition, the present review discusses the interaction between ESM1 and angiogenic factors, as well as the mechanisms through which ESM1 contributes to tumor angiogenesis. Furthermore, the reciprocal regulation between ESM1 and the TME is explored. Finally, the potential of targeting ESM1 as a therapeutic strategy for tumor angiogenesis is presented.

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Serum Levels Evaluation of TMSB10 and Endocan in Breast Cancer Patients and In-Vitro Study of Chrysin Effect on These Markers in MCF-7 cell line

Hammouda

Samra

Emarah

et al. 2023

Egyptian Journal of Basic and Applied Sciences

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A Comparison of the Circulating Endocan Levels between the Inflammatory and Malignant Diseases of the Same Organ: The Breast

Cited by 3 publications

References 30 publications

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)

Serum Levels Evaluation of TMSB10 and Endocan in Breast Cancer Patients and In-Vitro Study of Chrysin Effect on These Markers in MCF-7 cell line

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