A Comparison of the Biovailability of Paracetamol from a Fatty and a Hydrous Suppository Base and the Effect of Storage on the Absorption in Man

High‐dose rectal and oral acetaminophen in postoperative patients – serum and saliva concentrations

“…This is suggested by some authors to be the minimum effective antipyretic serum concentration ( 22, 23), although this is not finally proved. A literature survey (Medline search 1966–1999) of pharmacokinetic data published on administration of acetaminophen suppositories showed that after doses of 100–1000 mg acetaminophen maximum concentrations (C max ) of 9.2–86.5 μmol/l were reached 0.4–4.0 h (T max ) after administration ( 1–18). The data from the literature survey are depicted in Fig.…”

“…Different authors have demonstrated that the suppository base ( 7, 18, 24), the volume of the suppository ( 13, 17) and the particle size of acetaminophen ranging from 20 μm to 250 μm ( 16, 17, 25) can influence the rate and extent of absorption. Also the number of suppositories administered has been proposed to affect the bioavailability ( 1).…”

“…Serum concentrations of acetaminophen after administration of suppositories to adults have only been reported for doses lower than 1000 mg in the literature ( 1–18), but there seems to be an implied acceptance among clinicians that higher doses are needed to provide sufficient analgesia in adults. Studies investigating the pharmacokinetics of acetaminophen after doses exceeding current recommendations are needed ( 19).…”

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

“…So far, numerous methods have been reported for the analysis of AC in pharmaceuticals or in biological fluids. The methods include titrimetry [33] UV-vis spectrophotometry [34][35][36], quantitative thin-layer chromatography [37], high-performance liquid chromatography [38][39][40], and electrochemical methods [41][42][43][44].…”

Development and Validation of A UV Spectroscopic Method for Analysis of Paracetamol in Bulk Powder and Tablet

“…Numerous methods like titrimetry [4][5][6] , voltammetry 7 , fluorimetry 8 colorimetry 9 , UV-spectrophotometry [10][11] , quantitative thin-layer chromatography (TLC) 10 , high-performance liquid chromatography (HPLC) [12][13][14][15] and gas chromatography (GC) 16 have been reported for the analysis of paracetamol alone and its combinations in pharmaceuticals. Method development is the setting up of an analytical procedure that will be appropriate for the analysis of a particular sample and makes the analysis simpler, sensitive and easier.…”