A comparison of the anatomic distribution of cutaneous melanoma in two populations with different levels of sunlight: the west of Scotland and Queensland, Australia 1982–2001

Whiteman, David C.; Bray, Caroline; Siskind, Victor; Hole, David; MacKie, Rona M.; Green, Adèle C.

doi:10.1007/s10552-007-0123-1

Cited by 28 publications

(23 citation statements)

References 21 publications

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“…This too might be expected, at least for the head and neck, because of the head and neck’s generally greater exposure to the sun and greater risk of melanoma per unit of surface area than other body sites, particularly in older people. 44, 45 This possible association of multiple melanomas with higher sun exposure is supported by the stronger association of solar elastosis with first melanomas than single melanomas in the present study, observed associations of high sun exposure 44 and lack of sunscreen use 4 with an increased risk of multiple melanomas, and the finding that solar exposure at any age was associated with increased risk of developing multiple primary melanomas in the GEM study. 46 …”

Section: Discussionsupporting

confidence: 78%

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

et al. 2011

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Background 0.6–12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large international multi-center case-control study, we compared the clinicopathologic features of a subsequent melanoma with the preceding (usually the first) melanoma in patients with multiple primary cutaneous melanomas, and with those of melanomas in patients with single primary cutaneous melanomas. Methods Multiple primary melanoma (cases) and single primary invasive melanoma (controls) patients from the Genes, Environment and Melanoma (GEM) study were included if their tumors were available for pathologic review and confirmed as melanoma. Clinicopathologic characteristics of invasive subsequent and first melanomas in cases and invasive single melanomas in controls were compared. Results 473 pairs comprising a subsequent and a first melanoma and 1989 single melanomas were reviewed. Forward stepwise regression modeling in 395 pairs with complete data showed that, compared to first melanomas, subsequent melanomas were: more commonly contiguous with a dysplastic nevus; more prevalent on the head/neck and legs than other sites; and thinner. Compared with single primary melanomas, subsequent melanomas were also more likely to be: associated with a contiguous dysplastic nevus; more prevalent on the head/neck and legs; and thinner. The same differences were observed when subsequent melanomas were compared with single melanomas. First melanomas were more likely than single melanomas to have associated solar elastosis and no observed mitoses. Conclusions Thinner subsequent than first melanomas suggest earlier diagnosis, perhaps due to closer clinical scrutiny. The association of subsequent melanomas with dysplastic nevi is consistent with the latter being risk factors or risk markers for melanoma.

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Section: Discussionsupporting

confidence: 78%

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

et al. 2011

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“…The results are however in line with international research assessing anatomic distributions and gender profiles of melanoma (e.g. [42]) and naevi (e.g. [38]), found to be largely similar between populations residing at different latitudes [43].…”

Section: Discussionsupporting

confidence: 89%

Similar anatomical distributions of childhood naevi and cutaneous melanoma in young adults residing in northern and southern Sweden

Karlsson

Rodvall

Wahlgren

et al. 2015

European Journal of Cancer

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“…In men, the highest incidence rates are observed on the trunk overall [4], but after surface area adjustment, the highest rates are seen on the trunk of only younger men (under 40 years), but in older men they are seen on the head and neck [5][6][7]. In women, the highest incidence rates are observed on the trunk and limbs [4][5][6][7].…”

Section: Introductionmentioning

confidence: 97%

“…Altogether the limbs comprise 60% of the total skin surface area. Even after adjustment for surface area, the lower limbs show surprisingly high incidence rates of melanoma, especially in women living in temperate climates such as in Canada, New Zealand and Scotland [6,12], whereas women of similar ancestry living in sunny climates show highest incidence rates of melanoma per unit of skin on the upper followed by the lower limbs [7].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for limb melanomas compared with trunk melanomas in Queensland

Green

Siskind²

2012

Melanoma Research

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The objective of this study was to investigate the risk factors for melanoma on the arms and legs in comparison with well-known risk factors for trunk melanoma. The study was a population-based case-control study of 77 individuals with limb (25 arm; 52 leg) and 86 with trunk melanoma, who were representative of all the individuals newly-diagnosed with primary limb melanomas in Queensland during 1979-1980 and 232 controls. A single physician interviewed and examined all individuals and assessed complexion type, sun exposure history and other potential risk factors and clinical features. After multivariate analysis, the strongest risk factor for both limb and trunk melanomas was the presence of more than 10 naevi on the arm (odds ratio limb melanoma=41.4, 95% confidence interval 10.4-164), though on histology, a preexisting naevus was more strongly associated with trunk than limb melanoma (P<0.004). Associations with blonde/light brown hair, propensity to freckle and sunburn were similar for melanoma on both sites. A lifetime history of painful sunburns significantly raised the risk of trunk but not limb melanoma, whereas solar keratoses on the arm or face were more strongly associated with limb than with trunk melanoma (marginally significant, P(homogeneity)=0.056). High ambient solar ultraviolet radiation in adolescence was also a stronger risk factor for limb than for trunk melanoma. In conclusion, this population-based investigation into specific differences in causes of limb versus melanomas of other sites suggests that the risk factor profile is intermediate between the profiles for head/neck melanoma (mostly cumulative sun damage) and for trunk melanomas (most strongly related to naevi).

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A comparison of the anatomic distribution of cutaneous melanoma in two populations with different levels of sunlight: the west of Scotland and Queensland, Australia 1982–2001

Cited by 28 publications

References 21 publications

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

Similar anatomical distributions of childhood naevi and cutaneous melanoma in young adults residing in northern and southern Sweden

Risk factors for limb melanomas compared with trunk melanomas in Queensland

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