A Comparison of the Affective State and Quality of Life of Chemotherapy Patients Who Do and Do Not Develop Chemotherapy-Induced Oral Mucositis

Dodd, Marylin; Dibble, Suzanne L.; Miaskowski, Christine; Paul, Steven M.; Cho, Maria; MacPhail, Laurie A.; Greenspan, Deborah; Shiba, Gayle

doi:10.1016/s0885-3924(01)00277-9

Cited by 77 publications

(73 citation statements)

References 24 publications

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“…7,10,11 The literature indicates that 46% of patients with OM report 3 to 4 simultaneous OMrelated dysfunctions. 12 The HQoL was severely compromised for patients with OM, 11,13,14 especially in the functional sphere. 11 Patients with cancer have always identified OM as 1 of the major troubling symptoms and the primary cause of distress in their cancer treatment.…”

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confidence: 99%

New measure of health‐related quality of life for patients with oropharyngeal mucositis

Cheng

Leung

Thompson

et al. 2007

Cancer

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Scaffold‐guided tissue engineering based on synthetic and natural occurring polymers has gained much interest in recent years. In this article, the development of a polysaccharide‐based artificial extracellular matrix (AECM) is reported. Three‐dimensional, macroporous composite AECMs composed of chondroitin sulfate (ChS) and chitosan (Chito) were prepared by an interpolyelectrolyte complex/lyophilization method. The ChS–Chito composite AECMs were crosslinked with glutaraldehyde and calcium ions (Ca2+) and cocrosslinked with N,N‐(3‐dimethylaminopropyl)‐N′‐ethyl carbodiimide (EDC) and N‐hydroxysuccinimide (NHS). The crosslinking reactions were examined with Fourier transform infrared analysis. Glutaraldehyde and Ca2+ crosslinked with Chito and ChS, respectively, to produce different types of ChS–Chito semi‐interpenetrated networks. In contrast, EDC/NHS crosslinked with both Chito and ChS to produce ChS–Chito connected networks. In physiological buffer solutions, the Ca2+‐crosslinked ChS–Chito composite AECMs showed a lower swelling ratio than their EDC/NHS‐ and glutaraldehyde‐crosslinked counterparts. The ChS–Chito composite AECMs showed excellent antibacterial capability and biocompatibility according to the results of the in vitro antibacterial test and cytotoxic assay. This result suggested that the ChS–Chito composite AECMs might be a potential biomaterial for scaffold‐guided tissue‐engineering applications. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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confidence: 99%

New measure of health‐related quality of life for patients with oropharyngeal mucositis

Cheng

Leung

Thompson

et al. 2007

Cancer

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“…In addition to such common side effects as nausea 1 and fatigue, 2 many patients experience heightened emotional distress 3,4 and interference with physical, social, and role functioning 5 as a consequence of receiving chemotherapy. Although much of the effort to improve quality of life has focused on the evaluation of pharmacologic agents, such as antiemetic medications, 6 a number of randomized clinical trials have documented the benefits of psychosocial interventions for patients undergoing chemotherapy treatment.…”

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confidence: 99%

Efficacy and Costs of Two Forms of Stress Management Training for Cancer Patients Undergoing Chemotherapy

Jacobsen

Meade

Stein

et al. 2002

JCO

182

117

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E f fi c a c y a n d C o s t s o f T w o F o r m s o f S t r e s s M a n a g e m e n t T r a i n i n g f o r C a n c e r P a t i e n t s U n d e r g o i n g C h e m o t h e r a p yBy Paul B. Jacobsen, Cathy D. Meade, Kevin D. Stein, Thomas N. Chirikos, Brent J. Small, and John C. Ruckdeschel Purpose: Professionally administered psychosocial interventions have been shown to improve the quality of life of cancer patients undergoing chemotherapy. The present study sought to improve access to psychosocial interventions during chemotherapy treatment by evaluating the efficacy and costs of a patient self-administered form of stress management training that requires limited professional time or experience to deliver.Patients and Methods: Four hundred eleven patients about to start chemotherapy were randomly assigned to receive usual psychosocial care only, a professionally administered form of stress management training, or a patient self-administered form of stress management training. Quality-of-life assessments were conducted before randomization and before the second, third, and fourth treatment cycles. Intervention costs were estimated from both payer and societal perspectives.Results: Compared with patients who received usual care only, patients receiving the self-administered intervention reported significantly (P < .05) better physical functioning, greater vitality, fewer role limitations because of emotional problems, and better mental health. In contrast, patients who received the professionally administered intervention fared no better in terms of quality of life than patients receiving usual care only. Costs of the self-administered intervention were estimated to be 66% (from a payer perspective) to 68% (from a societal perspective) less than the average costs of professionally administered psychosocial interventions for patients starting chemotherapy.Conclusion: Evidence regarding the efficacy and favorable costs of self-administered stress management training suggests that this intervention has the potential to greatly improve patient access to psychosocial intervention during chemotherapy treatment.

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“…After reviewing titles and abstracts, 14 studies were identified as potentially relevant. [13][14][15][16][17][18][19][20][21][22][23][24][25][26] Reasons for exclusion (Table 2) 13-26 were quantitative study design and inadequate focus. Finally two studies 27,28 were included.…”

Section: Resultsmentioning

confidence: 99%

Patient experiences with oral mucositis caused by chemo-/radiotherapy: a critical qualitative literature review

2014

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Mucositis is one of the most common side effects of chemotherapy and radiotherapy. In order to develop an evidence-based clinical practice guideline for the management of tumor therapy-induced-oral mucositis, it was necessary to capture the patients' perspective. Therefore the aim of this critical literature review was to explore the experience of patients with therapy-induced-oral mucositis. Searches were carried out using a systematic search strategy in CINAHL and Medline. Qualitative studies investigating the view of cancer patients receiving chemotherapy and/or radiotherapy and suffering from oral mucositis were included. Study selection and quality assessment were performed by two independent reviewers. Only two qualitative studies (n=28 patients) met the inclusion criteria. Oral mucositis caused by cancer therapy is associated with serious complications concerning pain, eating, swallowing, speaking, sadness, lack of energy, and distress. Mucositis was described as the worst side effect of cancer therapy. Providing patient-centered care requires understanding the experience and the needs of patients and their families. Mucositis is associated with complex physical, psychological and social consequences. Unfortunately, both studies were performed in different cultural backgrounds and health care systems, so the results cannot simply be transferred to German-speaking countries. Further research is needed to gain a deeper understanding of living with mucositis.

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A Comparison of the Affective State and Quality of Life of Chemotherapy Patients Who Do and Do Not Develop Chemotherapy-Induced Oral Mucositis

Cited by 77 publications

References 24 publications

New measure of health‐related quality of life for patients with oropharyngeal mucositis

New measure of health‐related quality of life for patients with oropharyngeal mucositis

Efficacy and Costs of Two Forms of Stress Management Training for Cancer Patients Undergoing Chemotherapy

Patient experiences with oral mucositis caused by chemo-/radiotherapy: a critical qualitative literature review

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