A comparison of spectroscopic techniques for human breath analysis

Chow, Kam Kong; Short, Michael; Zeng, Haishan

doi:10.3233/bsi-120029

Cited by 19 publications

(16 citation statements)

References 76 publications

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“…Although the various forms of mass spectrometry, mainly gas chromatography-MS (GC-MS), proton transfer reaction-MS (PTR-MS), selected ion flow tube-MS (SIFT-MS) [50], provide information on exhaled substances with molecular identification and quantification, other more flexible, cheap and functional sensing platforms are electronic noses (e-noses). Such devices fingerprint the ensemble of exhaled VOCs (called human exhalome) in terms of gas/VOC sensors response patterns; their challenge is to become a screening non-invasive technique supporting gold mass spectrometric techniques [40,41,[51][52][53][54].…”

Section: Rationalementioning

confidence: 99%

A Low-Cost Breath Analyzer Module in Domiciliary Non-Invasive Mechanical Ventilation for Remote COPD Patient Monitoring

Radogna

Siciliano

Sabina

et al. 2020

Sensors

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Smart Breath Analyzers were developed as sensing terminals of a telemedicine architecture devoted to remote monitoring of patients suffering from Chronic Obstructive Pulmonary Disease (COPD) and home-assisted by non-invasive mechanical ventilation via respiratory face mask. The devices based on different sensors (CO2/O2 and Volatile Organic Compounds (VOCs), relative humidity and temperature (R.H. & T) sensors) monitor the breath air exhaled into the expiratory line of the bi-tube patient breathing circuit during a noninvasive ventilo-therapy session; the sensor raw signals are transmitted pseudonymized to National Health Service units by TCP/IP communication through a cloud remote platform. The work is a proof-of-concept of a sensors-based IoT system with the perspective to check continuously the effectiveness of therapy and/or any state of exacerbation of the disease requiring healthcare. Lab tests in controlled experimental conditions by a gas-mixing bench towards CO2/O2 concentrations and exhaled breath collected in a sampling bag were carried out to test the realized prototypes. The Smart Breath Analyzers were also tested in real conditions both on a healthy volunteer subject and a COPD suffering patient.

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Section: Rationalementioning

confidence: 99%

A Low-Cost Breath Analyzer Module in Domiciliary Non-Invasive Mechanical Ventilation for Remote COPD Patient Monitoring

Radogna

Siciliano

Sabina

et al. 2020

Sensors

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“…Gold standard instrumentation available for metabolomics is standalone or hyphenated mass spectrometry (MS), ion mobility spectrometry (IMS), nuclear magnetic resonance (NMR), high-performance liquid chromatography (HPLC), gas chromatography (GC) and Fourier transform infrared spectroscopy (FT-IR). These analytical techniques are complementary allowing qualitative, quantitative, structural and time evolving information about the metabolites [3].…”

Section: Metabolomicsmentioning

confidence: 99%

Volatolomics: A broad area of experimentation

Giannoukos

Agapiou

Brkić

et al. 2019

Journal of Chromatography B

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Chemical analysis (detection and monitoring) of compounds associated with the metabolic activities of an organism is at the cutting edge of science. Volatile metabolomics (volatolomics) are applied in a broad range of applications including: biomedical research (e.g. disease diagnostic tools, personalized healthcare and nutrition, etc.), toxicological analysis (e.g. exposure tool to environmental pollutants, toxic and hazardous chemical environments, industrial accidents, etc.), molecular communications, forensics, safety and security (e.g. search and rescue operations). In the present review paper, an overview of recent advances and applications of volatolomics will be given. The main focus will be on volatile organic compounds (VOCs) originating from biological secretions of various organisms (e.g. microorganisms, insects, plants, humans) and resulting fusion of chemical information. Bench-top and portable or field-deployable technologies-systems will also be presented and discussed.

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“…Breath analysis using laser spectroscopic techniques is only a very recent advancement and, to a great extent relies on recent development of diode lasers capable of covering a wide spectral range of molecular fingerprints [ 95 ]. A good review of breath analysis using laser spectroscopic techniques is given in [ 95 , 96 ].…”

Section: Instrumentation and Analytical Techniquesmentioning

confidence: 99%

A Review of Analytical Techniques and Their Application in Disease Diagnosis in Breathomics and Salivaomics Research

Beale

Jones

Karpe

et al. 2016

IJMS

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The application of metabolomics to biological samples has been a key focus in systems biology research, which is aimed at the development of rapid diagnostic methods and the creation of personalized medicine. More recently, there has been a strong focus towards this approach applied to non-invasively acquired samples, such as saliva and exhaled breath. The analysis of these biological samples, in conjunction with other sample types and traditional diagnostic tests, has resulted in faster and more reliable characterization of a range of health disorders and diseases. As the sampling process involved in collecting exhaled breath and saliva is non-intrusive as well as comparatively low-cost and uses a series of widely accepted methods, it provides researchers with easy access to the metabolites secreted by the human body. Owing to its accuracy and rapid nature, metabolomic analysis of saliva and breath (known as salivaomics and breathomics, respectively) is a rapidly growing field and has shown potential to be effective in detecting and diagnosing the early stages of numerous diseases and infections in preclinical studies. This review discusses the various collection and analyses methods currently applied in two of the least used non-invasive sample types in metabolomics, specifically their application in salivaomics and breathomics research. Some of the salient research completed in this field to date is also assessed and discussed in order to provide a basis to advocate their use and possible future scientific directions.

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A comparison of spectroscopic techniques for human breath analysis

Cited by 19 publications

References 76 publications

A Low-Cost Breath Analyzer Module in Domiciliary Non-Invasive Mechanical Ventilation for Remote COPD Patient Monitoring

A Low-Cost Breath Analyzer Module in Domiciliary Non-Invasive Mechanical Ventilation for Remote COPD Patient Monitoring

Volatolomics: A broad area of experimentation

A Review of Analytical Techniques and Their Application in Disease Diagnosis in Breathomics and Salivaomics Research

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