A comparison of sodium picosulphate (Laxoberal) with standardised senna (‘Senokot’) in geriatric patients

Wj, MacLennan; Afwm, Pooler

doi:10.1185/03007997409111877

Cited by 37 publications

(29 citation statements)

References 7 publications

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“…Of the 986 screened studies, seven studies met the inclusion criteria and were included in the systematic review (Figure ). All of the studies were RCTs, four of which were double‐blinded, two of which used crossover design and two of which were open‐label trials . The studies were conducted in the UK, USA, Finland and Taiwan.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and safety of laxatives for chronic constipation in long‐term care settings: A systematic review

2018

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Section: Resultsmentioning

confidence: 99%

“…Senna was the most studied intervention in the included RCTs, either as the main intervention or as the comparator. These trials were of different quality levels according to Jadad scale.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of laxatives for chronic constipation in long‐term care settings: A systematic review

2018

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“…From details of repeat prescriptions we identified all asthmatic patients attending a general practice who were aged [13][14][15][16][17][18][19][20][21][22] and used a metered dose inhaler. We notified the patients to come to the surgery with the inhalers they were currently using and any held in reserve.…”

Section: Subjects Methods and Resultsmentioning

confidence: 99%

Problems in assessing contents of metered dose inhalers.

Williams¹,

Williams²,

Kruchek³

1993

BMJ

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* Chronic constipation is common in elderly people in long stay hospital and nursing home care and regular laxative treatment is often required * There are few comparative clinical studies of commonly used laxatives * In this study a senna-fibre combination was more effective than lactulose in long stay elderly patients with constipation * Both treatments were well tolerated * The superior efficacy of the senna-fibre combination, without increase in side effects, resulted in considerable cost benefit compared with lactulose.combination the incidence of adverse effects was no different, both compounds being well tolerated.The issue of cost effectiveness was addressed in this study. A higher daily dose was needed for an effect with lactulose. There were significant cost savings with the senna-fibre combination over the study period. Extrapolation ofthese data to the large numbers of long stay elderly people in nursing homes and hospitals who require regular laxatives could result in considerable cost savings. These results would seem to concur with statements on the relative expense and efficacy of lactulose.' 4 12In conclusion, both the senna-fibre combination and lactulose were effective, well tolerated treatments for chronic constipation in long stay elderly patients. Under the study conditions the senna-fibre combination was more effective than lactulose and was a less expensive regimen, a significant advantage in times of clinical and financial audit. We thank the medical, nursing, and pharmacy staff in the participating units for their assistance with this study and Galen Limited and Madaus AG for their contribution towards the study. This means that such patients may tend to run out of medication, which could be related to the excess mortality from asthma. We investigated whether asthmatic patients were able to reliably assess the amount of medication remaining in a metered dose inhaler and whether they ever ran out ofmedication. Subjects, methods, and resultsFrom details of repeat prescriptions we identified all asthmatic patients attending a general practice who were aged [13][14][15][16][17][18][19][20][21][22] and used a metered dose inhaler. We notified the patients to come to the surgery with the inhalers they were currently using and any held in reserve. We asked the patients about their use of inhalers and assessed the inhalers by weight.2 When an inhaler's canister floats (at its floating weight) it has delivered its licensed number of doses.2 Although expellant may be obtained from an inhaler beyond its licensed number of doses (36 extra puffs on average for a Ventolin inhaler), there are no published data on the drug content of each puff. As 48 hours is generally required to get a repeat prescription from a general practice, a canister's red weight is when it contains enough expellant for 48 hours' use. 03 Agonists in metered dose inhalers are usually prescribed at two puffs four times daily. The red weight is thus the empty weight (when no further expellant can be obtained) plus the weight of ei...

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“…While there are problems associated with long-term laxative usage, there is a significant morbidity associated with constipation in frail elderly people, and regular laxatives are required [2], Studies have shown no difference between lactulose and ispaghula [1] or lactulose and irritant laxatives [7]; psyllium with senna was better than psyllium alone [8], and picosulphate and senna were equivalent in long-stay elderly patients [4], In the present study Agio lax was superior to lactulose. This result may be explained in part by the additional effects of senna which may be advantageous in the atonic constipation seen in elderly patients where lactulose or fibre alone are insufficient.…”

Section: Discussionmentioning

confidence: 99%

“…Both were effective and well tol erated, but Agiolax proved statistically superi or on all efficacy measures. Bowel frequency and consistency and the dose required for satisfactory effect are the most commonly used measures in studies of this nature [1,4].…”

Section: Discussionmentioning

confidence: 99%

Short Comunication: A Comparison of Agiolax and Lactulose in Elderly Patients with Chronic Constipation

Passmore¹,

Davies

Flanagan³

et al. 1993

Pharmacology

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In a double-blind crossover study the efficacies of Agiolax, a combination of fibre and senna pod, and lactulose were compared in 77 long-stay elderly patients with chronic constipation. Mean daily bowel frequency, stool consistency and ease of evacuation were significantly greater with Agiolax than lactulose. The recommended dose was exceeded more frequently with lactulose than Agiolax (χ² = 8.38, p < 0.01). Adverse effects were not different for the 2 treatments. In long-stay elderly patients with chronic constipation Agiolax and lactulose were well tolerated, but Agiolax proved a more effective treatment.

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A comparison of sodium picosulphate (Laxoberal) with standardised senna (‘Senokot’) in geriatric patients

Cited by 37 publications

References 7 publications

Efficacy and safety of laxatives for chronic constipation in long‐term care settings: A systematic review

Efficacy and safety of laxatives for chronic constipation in long‐term care settings: A systematic review

Problems in assessing contents of metered dose inhalers.

Short Comunication: A Comparison of Agiolax and Lactulose in Elderly Patients with Chronic Constipation

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