A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia

Alexander, Peter; Gicas, Kristina M.; Cheng, Alex; Lang, Donna J.; Procyshyn, Ric M.; Vertinsky, Alexandra T.; Panenka, William J.; Thornton, Allen E.; Rauscher, Alexander; Wong, Jamie Y X; Chan, T M; Jones, Andrea A.; Vila‐Rodriguez, Fidel; Honer, William G.; Barr, Alasdair M.

doi:10.1007/s00213-019-05298-w

Cited by 13 publications

(4 citation statements)

References 77 publications

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“…Increased positive symptoms score in stimulant-induced psychosis were believed to re ect the dysregulation of the mesolimbic dopamine pathway [40,41], and which may be mediated by frontal, striatal and limbic regions [42]. In this study, we found signi cantly increased positive symptoms in MAUD patients present as increased schizophrenia nuclear symptoms score.…”

Section: Discussionsupporting

confidence: 54%

“…The previous study has also found the smaller volume in left parietal/temporal lobe in schizophrenia patients with concurrent stimulant dependence [41], reduced gray matter in the parietal cortices in MAUD patients [47]. The disconnection within the parietal, temporal and occipital regions or with other regions, may be related to the abnormal neural response to visual and/or auditory stimuli in MAUD patients [48].…”

Section: Discussionmentioning

confidence: 90%

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Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder 

Li¹,

Wang²,

Lyu³

et al. 2021

Preprint

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Background: Both methamphetamine use disorder (MAUD) and heroin use disorder (HUD) were related to the activation of the dopamine transmission, while the psychological symptoms caused by HUD and MAUD were significantly different. The topological organization of structural connection that may underlie these differences remains unknown. Methods: Demographic matched 23 male MAUD patients, 20 HUD patients, and 21 healthy controls (HC) participated in the analysis. Diffusion tensor imaging and probabilistic tractography were used for white matter network construction. Psychological symptoms were evaluated by the Symptom Checklist-90. Differences of graph-level and nodal-level properties among groups were explored. The network Hubs distribution and the relationship between the network alteration and psychological status were identified. Results: MAUD patients demonstrated significantly increased scores in anxiety, hostility, and schizophrenia nuclear symptoms. HUD group showed significantly increased global efficiency and network strength than HC and increased network strength than MAUD. Compared with HUD, the MAUD group showed significantly decreased nodal strength and efficiency distributed mainly in the temporal, parietal and occipital regions. We also found the network Hubs were decreased in MAUD group but increased in HUD group. The nodal strength in right superior temporal gyrus was significantly correlated with the psychological scores in MAUD patients. Conclusion: These findings reflect the significant differences in topological structural connection between HUD and MAUD patients. These pieces of evidences help shed some light on the neurobiological mechanisms of the psychological difference between HUD and MAUD, and extend our understanding of the structural disruption underline the MAUD related psychological symptoms.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 90%

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder 

Li¹,

Wang²,

Lyu³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Corresponding to its brain alteration, the MAP also had lighter psychotic symptoms than the SCZ. A recent study by Alexander et al ( Alexander et al, 2019 ) has supported this, by demonstrating less severe symptoms in subjects with stimulant-induced psychosis than schizophrenia patients. It is difficult to say how MA work on the progression of neuropathology, with primary effects or alternatively, based on a secondary hit.…”

Section: Discussionmentioning

confidence: 86%

Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia

Jia

Jiang

Wang

et al. 2022

NeuroImage: Clinical

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“…Participants were 19 years or older and able to give informed consent. The study took approximately four hours to complete per subject and consisted of self-report questionnaires and the Mini-International Neuropsychiatric Interview (MINI) version 6, conducted by a trained research associate as previously (Alexander et al, 2019;Barr et al, 2011;Zhou et al, 2019). Participants were provided an honorarium for their time.…”

Section: Study Populationmentioning

confidence: 99%

Are Younger Medical Cannabis Users at Risk? Comparing Patterns of Use and Mental Health in Younger and Older Medical Cannabis Dispensary Users

Lo¹,

MacCallum²,

Yau³

et al. 2023

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While there has been a considerable amount of research on recreational cannabis use in youth to date, much less is known about patterns of medical cannabis use in youth. Adult medical versus recreational cannabis users may differ in how they use the product on important factors such as dose, frequency and route of ingestion, and so it is important to understand whether adolescents and young adults differ in how they use medical cannabis compared to adults, and if this increases risk of impaired mental health. In the present study, one hundred members of a community cannabis dispensary who endorsed cannabis use for medical purposes were assessed for major psychiatric disorders, and completed questionnaires related to stress, depression, sleep and somatic symptoms. Detailed information about cannabis use was collected. In the sample, 35% were aged 19-24 years old, and 24% were aged 25-30 (categorized as youth/young adults). In comparison to the older medical cannabis users, there were unexpectedly few differences, both in mental health status as well as pattern of medical cannabis use. These findings contrast with those of recreational cannabis users, and indicate that medical cannabis in youth may be as effective and well-tolerated as in older adults.

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A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia

Cited by 13 publications

References 77 publications

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder

Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia

Are Younger Medical Cannabis Users at Risk? Comparing Patterns of Use and Mental Health in Younger and Older Medical Cannabis Dispensary Users

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A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia

Cited by 13 publications

References 77 publications

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder&nbsp;

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder&nbsp;

Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia

Are Younger Medical Cannabis Users at Risk? Comparing Patterns of Use and Mental Health in Younger and Older Medical Cannabis Dispensary Users

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Product

Resources

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Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder

Difference In The Topological Organization of White Matter Structural Connectome Between Methamphetamine and Heroin Use Disorder