A Comparison of Red Cell Rejuvenation versus Mechanical Washing for the Prevention of Transfusion-associated Organ Injury in Swine

Abstract

What This Article Tells Us That Is New • In a porcine model, red blood cell washing along with an inosine rejuvenation solution restored red cell energy stores, reduced inflammatory responses, and reduced transfusionassociated organ injury in swine in 14-day-old stored blood

Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion

“…This may be in line with a study in a rat hemorrhage model, where it was shown that liver injury was lower in animals receiving fresh blood compared to stored blood . The limited benefit of washing of products in our study reflects findings in a porcine model, in which washing of RBC products did not reduce organ injury compared to standard transfusion products . These previous studies focused on transfusion of RBC blood products only.…”

Rejuvenation of allogenic red cells: benefits and risks

“…Wozniak, Cardigan and colleagues evaluated the effects of red cell rejuvenation on transfusion‐associated organ injury in an established swine model of transfusion‐associated organ injury . In this model, 14‐day‐pig red cells exhibited characteristics comparable to day 35 human red cells.…”

Platelet vesicles are potent inflammatory mediators in red blood cell products and washing reduces the inflammatory phenotype

“…Washing RCCs to reduce plasma and remove soluble mediators and/or inflammatory components may reduce immunomodulation associated with blood components, and may lead to better post‐transfusion outcomes . Noteworthy, while washing of RCC products is well established, the clinical significance of washed RBC is still uncertain . For instance, it has been shown that transfusion of washed RCCs to children undergoing cardiac surgery reduces postoperative inflammation .…”