A comparison of propofol and etomidate as anaesthetic agents for elective non-cardiac surgery

Kumar, Amit; Shekhawat, Kamlesh Kanwar; Sharma, Roma; Mangwana, Pramod

doi:10.18203/2320-6012.ijrms20184062

Cited by 4 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…Our finding is also similar to the finding of Kumar A et al studies on propofol and etomidate as anaesthetic agent for elective non cardiac surgery where they found that there was no statistically significant difference in two group regarding nausea and vomiting. 28…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Etomidate and Propofol Induction on Haemodynamic Response and Serum Cortisol Levels in Patients Undergoing Laparoscopic Cholecystectomy

Wahab¹,

Heisnam²,

Nushrat³

et al. 2020

jebmh

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BACKGROUND The choice of an anaesthetic agent for induction of anaesthesia is based mainly on its pharmacodynamic properties. We wanted to compare the effect of etomidate and propofol induction on haemodynamic response, serum cortisol level, and adverse effects in patients undergoing laparoscopic cholecystectomy. METHOD After approval from the institutional ethics committee, eighty-three American Society of Anaesthesiologist (ASA) grade I or II patients of 20-60 yrs. undergoing elective laparoscopic cholecystectomy were enrolled in the study. Patients were allocated randomly to receive either propofol or etomidate for induction of anaesthesia. Anaesthesia was maintained in both the groups with sevoflurane air and oxygen mixture, vecuronium bromide 0.08 mg/Kg for muscle relaxant. RESULTS The mean baseline haemodynamic parameters (SBP, DBP, MAP, HR) are comparable in both the groups. Post induction blood pressure was significantly lower in propofol group as compared to etomidate group. Immediately after intubation surge in blood pressure was more in etomidate group than propofol group. Also there was no difference in mean baseline serum cortisol levels in both the groups. But after induction, serum cortisol level was significantly decreased in etomidate group. However, after 24 hrs. of induction mean serum cortisol level in both the groups returns to baseline value. CONCLUSIONS Etomidate has more stable cardiovascular profile than propofol. It has the added advantage of minimizing induction hypotension which can cause coronary hypoperfusion, dysrhythmia and even cardiac arrest. Etomidate causes temporary reduction in serum cortisol level and this reduction in serum cortisol gets normalized 24 hrs. after induction.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Etomidate and Propofol Induction on Haemodynamic Response and Serum Cortisol Levels in Patients Undergoing Laparoscopic Cholecystectomy

Wahab¹,

Heisnam²,

Nushrat³

et al. 2020

jebmh

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“…Jing Wu et al 14 , also observed that Etomidate is much safer than Propofol for first-trimester surgical abortions and using a lower dose of Etomidate, supplemented with Fentanyl and Midazolam, in reducing adverse effects like myoclonus and postoperative nausea and vomiting. Amit Kumar et al in 2018 15 also conducted a similar study for elective non-cardiac surgery to compare Propofol and Etomidate as anaesthetic agents and found that Etomidate is a better intravenous induction agent of anaesthesia than Propofol in hemodynamically unstable patient also as it has faster onset of action with less pain and post-operative nausea, vomiting with good hemodynamic stability. The SpO 2 in both the groups was maintained at 100% throughout the surgery and also in the post op period.ECG monitoring was done in both the groups throughout the procedure.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Hemodynamic Effects of IV Etomidate vs IV Propofol in Functional Endoscopic Sinus Surgery

Singh¹,

Road²

2019

jmscr

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Laryngoscopy and endotracheal intubation stimulates cardiovascular responses such as hypertension, tachycardia and dysrhythmias. Sudden hypotension, arrhythmias, and cardiovascular collapse are threatening complications following Injection of induction agent in hemodynamically unstable patients demanding a search for safe inducing agent. A prospective randomized study was conducted on 60 ASA Grade I and II patients aged 18-60 yrs scheduled for Functional Endoscopic Sinus Surgery (FESS).They were divided into two groups of 30 each. One group received Inj. Etomidate 0.3mg/kg as induction agent Grp E and Inj. Propofol 2mg/kg in Grp F preceeded by Inj. Midazolam 0.02mg/kg and Inj.. Fentanyl 3µgm/kg. as premedication . Patients were maintained on O2 +Nitrous oxide +Isoflurane +intermittent doses of Inj. Vecuronium. Reversal done with Inj. Neostigmine 50 mcg/kg & Inj. Glycopyrrolate 10mcg/kg IV. before extubation . Haemodynamic parameters were observed at different intervals. Statistical data confirmed that Etomidate was a better inducing agent being haemodynamically stable with minimum side effects than Propofol.

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Comparative Study of Etomidate and Propofol for Induction of General Anesthesia in Elderly Patients

Shah

Zalawadiya

Patel

et al. 2023

PIJR

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Introduction: An ideal induction agent for general anesthesia should have hemodynamic stability, minimal respiratory side effect and rapid recovery. Presently etomidate and propofol are popular rapid acting inducing agents. Material and methods: After obtaining informed written consent from patients this prospective, randomized, double blind study was conducted in 100 patients of ASA grade 3 and 4 posted for elective surgeries under general anaesthesia. They were divided into two groups of 50 in each group based on random number as group A and group B. The patients in Group A given Inj. Propofol and the patients in Group B received Inj. Etomidate. Parameters such as heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and spo2 were monitored continuously and recorded. Incidence and degree of pain of myoclonic movements were recorded. Demographic variables such as age Result: , gender, weight and ASA grade were comparable no significant difference existed between both the groups.Baseline mean heart rate, mean systolic blood pressure and mean diastolic blood pressure were comparable in both the Groups. (P>0.05)Significant (P<0.05) fall in mean systolic blood pressure, mean diastolic pressure and mean arterial pressure was observed immediately after induction, at 2, 5, 10 minutes up to 30 minutes in group A (propofol) compare to group B (etomidate). After then no significant difference seen in mean systolic pressure, mean diastolic pressure and mean arterial pressure. Etomidate was found ideal for its hemodynamic stability when compared to Propofol Conclusion: along with less incidence of pain on injection, the only drawback being high incidence of myoclonus elderly patient

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A comparison of propofol and etomidate as anaesthetic agents for elective non-cardiac surgery

Cited by 4 publications

References 13 publications

A Comparative Study of the Effect of Etomidate and Propofol Induction on Haemodynamic Response and Serum Cortisol Levels in Patients Undergoing Laparoscopic Cholecystectomy

A Comparative Study of the Effect of Etomidate and Propofol Induction on Haemodynamic Response and Serum Cortisol Levels in Patients Undergoing Laparoscopic Cholecystectomy

Comparison of Hemodynamic Effects of IV Etomidate vs IV Propofol in Functional Endoscopic Sinus Surgery

Comparative Study of Etomidate and Propofol for Induction of General Anesthesia in Elderly Patients

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