A comparison of proliferation levels in normal skin, physiological scar and keloid tissue

Zhang, Ming‐Zi; Dong, Xinhang; Zhang, Wenchao; Li, Ming; Si, Loubin; Liu, Yifang; Li, Haoran; Zhao, Pengxiang; Liu, Mengyu; Adzavon, Yao Mawulikplimi; Wang, Xiaojun; Long, Xiao; Ding, Yu

doi:10.1080/2000656x.2021.2017294

Cited by 10 publications

(18 citation statements)

References 23 publications

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“…Thirteen studies reported experiments with JAK and/or STAT inhibitors 8,14,15,17–26 . Seven studies reported on JAK and/or STAT expression in (keloid) cells or tissues without involving drug testing 9,27–32 . All included articles were preclinical studies with in vitro human keloid cells, human keloid biopsies or a combination of both.…”

Section: Resultsmentioning

confidence: 99%

“…Another cytokine that has a role in keloid pathogenesis is IL‐1β. IL‐1β enhanced fibrosis in the late stage of wound healing and various studies reported that blocking IL‐1β inhibits keloid progression 27 …”

Section: Discussionmentioning

confidence: 99%

“…when compared to healthy volunteer skin. 27 The retrieved studies only described the association of keloids with STAT3 and STAT1 and not with other STAT proteins.…”

Section: Jak and Stat3 Expression Are Elevated In Keloid Tissue And K...mentioning

confidence: 99%

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The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis

Yin

Wolkerstorfer

Lapid

et al. 2023

Experimental Dermatology

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Keloid tissues contain inflammatory cells and upregulated pro‐inflammatory cytokines. The Janus kinase (JAK)‐signal transducer and activator of transcription (STAT) pathway mediate cellular responses to these cytokines. We performed a systematic review on the role of the JAK–STAT pathway in keloid pathogenesis and the evidence for JAK–STAT inhibitors in keloid treatment. The search combined the terms (1) keloid and (2) JAK or TYK or STAT and included MeSH terms and synonyms. Two reviewers screened the articles and assessed the full texts on eligibility. Data were collected on the tested drugs and molecules, the type of cells and tissues used in the experiments, and study findings on the association between the JAK–STAT pathway and keloid cells and tissues. A total of twenty preclinical studies were included. Eleven preclinical studies proved that STAT3 expression and phosphorylation are enhanced in keloid tissue and keloid fibroblasts. Thirteen different JAK and/or STAT inhibitors were investigated. Tested drugs inhibited keloid progression as demonstrated by different processes, including reduced collagen production, cell proliferation and migration, increased cell cycle arrest and apoptosis, enhanced antioxidant responses, decreased (paracrine) signalling, and decreased profibrotic gene expression. No clinical studies have been published to date. Preclinical studies indicate a role for the JAK–STAT pathway in keloid pathogenesis and a potential role for JAK–STAT inhibitors in keloid treatment. The effect of these drugs should be further investigated on relevant biomarkers in a human keloid skin model, preferably including immune cells besides keloid fibroblasts and keratinocytes and in clinical studies.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis

Yin

Wolkerstorfer

Lapid

et al. 2023

Experimental Dermatology

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“…52 Fibroblasten regulieren Wachstumsfaktorrezeptoren hoch, die eine erhöhte Sensitivität gegenüber TGF-β und platelet derived growth factor (PDGF) aufweisen und zu einer verstärkten Proliferation führen. 53,54 Gene der M2-Makrophagen-Population werden in Keloiden überexprimiert, Fibroblasten vermehrt rekrutiert, und diese durch die verstärkte Ausschüttung von Wachstumsfaktoren vermehrt zu Myofibroblasten transformiert. 55 Die lokale Aktivierung von Mechanotransduktion-Signalwegen könnte außerdem die Ausbreitung von keloidalem Narbengewebe über die Wundgrenzen hinaus erklären.…”

Section: Keloideunclassified

Therapie pathologischer Narben

Riedemann

Schmidt

Baron

2023

J Deutsche Derma Gesell

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anderen Institution Erklärung zu nicht-finanziellen Interessen: DDG. ZusammenfassungEine Narbe entsteht nach Auftreten eines tiefen Gewebedefekts im Rahmen des physiologischen Wundheilungsprozesses. Der initialen Entzündungsreaktion folgt eine Proliferation von Bindegewebszellen, die eine Fibrose als definitiven Gewebeersatz ausbilden. Störungen können in allen Stadien des Prozesses auftreten und äußern sich hauptsächlich in Wundheilungsstörungen oder der Ausbildung atropher und hypertropher Narben beziehungsweise Keloiden. Schwerpunkt dieses Artikels ist die Therapie pathologischer Narben, die unter anderem wegen funktioneller Einschränkungen, Beschwerden und Stigmatisierung eine Therapieindikation darstellen. Dabei werden konservativ-medikamentöse, physikalische sowie chirurgische und lasertherapeutische Ansätze verfolgt. Grundlage ist das Verständnis pathophysiologischer Mechanismen und Einflussfaktoren zur Therapiewahl sowie ein interdisziplinärer und interprofessioneller Therapieansatz. SummaryA scar develops following the appearance of a deep tissue defect as part of the physiological wound healing process. The initial inflammatory response is followed by proliferation of connective tissue cells, which form fibrosis as a final tissue substitute. Disorders can occur at all stages of the process and are most commonly manifested as impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. The focus of this article is on the treatment of pathologic scars, which are an indication for therapy due to functional limitations, complaints, and stigmatization, among other reasons. Conservative medical, physical, surgical and laser therapeutic approaches are pursued. The basis for this is an understanding of the pathophysiological mechanisms and factors influencing the choice of therapy, as well as an interdisciplinary and interprofessional therapeutic approach. † Die beiden erstgenannten Autoren haben gleichermaßen zum Artikel beigetragen.

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“…At present, countries all over the world, especially Japan, attach great importance to the construction and maintenance of toilets. Whether it is home life or public health, Zhang [5] found that intelligent toilets have been widely used in the daily life of Japanese people.…”

Section: Literature Reviewmentioning

confidence: 99%

Green Development and Self-Service Payment System of Intelligent Pet Public Toilet Based on Artificial Intelligence

Wang

Gong

Lyu

et al. 2022

Mobile Information Systems

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Controversy about pets such as dogs is also growing, and the public health controversy is the most obvious. In order to solve the public health problem of pets outdoors, meet the needs of pet family pets for outdoor hygiene, and make up for the lack of smart pet public toilets in the market and with the development of artificial intelligence technology, the authors propose that “pet toilets” have been put into use in many cities and the emergence of this new thing is mainly aimed at the substantial increase in the number of pets such as dogs in cities, hoping to better solve the problem of pet dogs urinating in public places in the community and provide a more convenient dog service measure for urban residents. Through a questionnaire survey of 100 random volunteers, it was found that 69 people believed that pet toilets were very necessary for society; therefore, from the perspective of artificial intelligence, the development of smart pet toilets and self-service payment systems has been focused on.

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A comparison of proliferation levels in normal skin, physiological scar and keloid tissue

Cited by 10 publications

References 23 publications

The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis

The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis

Therapie pathologischer Narben

Green Development and Self-Service Payment System of Intelligent Pet Public Toilet Based on Artificial Intelligence

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