A Comparison Of Pressor Response To Induction & Endotracheal Intubation With Thiopentone And Propofol.Prospective,Randomised Study.

Abstract

Aims And Objectives-To quantify and compare cardiovascular response to direct laryngoscopy and endotracheal intubation using Thiopentone and Propofol. Material and Methods-200 patients of ASA (American Society of Anaesthesiology) Grade -I and II between 15-60 years, of either sex scheduled for elective and emergency surgery were selected. Group A received Inj. Thiopentone sodium 5 mg/kg (2.5%) and Group B received Inj. Propofol 2 mg/kg (1%), 100 patients in each group. Pulse rate (PR), systolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP) and rate-pressure product (RPP) were recorded pre and postinduction and post-intubation at 1,3 and 5 min. Results-At 1 min after laryngoscopy and intubation, PR increased significantly in both the groups. Increase was significantly more in Group A than in Group B. At 3 min after intubation, Increase in PR was significantly greater in Group A than in Group B. At 5 minutes, PR decreased in both the groups, difference being statistically insignificant. SBP, DBP, MAP and RPP decreased significantly after induction and intubation at 1, 3, 5 min in Group B than in Group A. Conclusion -A single induction dose of propofol attenuates, but does not prevent the pressor response to laryngoscopy and intubation. Propofol provides stable hemodynamic condition during induction, laryngoscopy and endotracheal intubation when compared to thiopentone.