A Comparison of Postoperative Acid-Base Equilibrium and Respiratory Adequacy After Two Types of Neuroleptanalgesia

HOLLM??N, A.; Hakalehto, J; Lauritsalo, K.; Mattila, Marco

doi:10.1097/00132586-196702000-00031

Cited by 2 publications

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“…Gurtner, Doenicke and Spiess (1964) reported normal values of Paco 3 in the postoperative period after the use of phenoperidine and haloperidol, although they used nalorphine in 68 per cent of their cases. After the use of large doses of dehydrobenzperidol and fentanyl, Grabow and Allemand (1964) reported a mean Paooj of 48 mm Hg which had returned to normal levels within 2 hours, unlike the changes found after the phenoperidine and haloperidol combination by Hollmen et al (1966). Their measurements showed elevated values for Paco, at 30, 90, and 180 minutes after the end of anaesthesia, the range of Pa^ following upper abdominal surgery being 49-78 mm Hg at 30 minutes.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Drugs Used in Neuroleptanalgesia on Cardiovascular and Ventilatory Function

Prys‐Roberts

Kelman

1967

British Journal of Anaesthesia

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The circulatory and ventilatory influences of various combinations of the narcotic analgesics phenoperidine and fentanyl, and the neuroleptics haloperidol and dehydrobenzperidol, were investigated during nitrous oxide anaesthesia in 230 patients. Measurements of cardiac output and other haemodynamic variables in nine patients supported the general findings that the cardiovascular effects of the analgesics were modified by alterations of ventilation, in particular the haemodynamic effects of concurrent hypercapnia. Serious circulatory disturbances were not found following premedication with neuroleptic drugs. Mechanisms of ventilatory depression following the use of the analgesics have been evaluated, and indices of ventilation and arterial oxygenation show that postoperative values after neuroleptanalgesia are comparable to those-after other methods of anaesthesia. The rationale of neuroleptanalgesia combined with light general anaesthesia is explored and the pharmacology of the drugs is reviewed.

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Section: Discussionmentioning

confidence: 99%

The Influence of Drugs Used in Neuroleptanalgesia on Cardiovascular and Ventilatory Function

Prys‐Roberts

Kelman

1967

British Journal of Anaesthesia

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“…Numerous reports have appeared in the American and Canadian literature on the use of these drugs in anaesthesia. In this country, the published reports have concerned either the use of the neuroleptanalgesic state in specialized forms of anaesthesia (Larson, 1963;Brown, 1964;Smith and Hollis, 1966;Cameron, 1967;Baskett et al, 1969;Kay, Keaney and Taylor, 1970;Monks and Lumley, 1972) or on the physiological effects resulting (Fitch et al, 1969;Hollmen et al, 1966;Prys-Roberts and Kelman, 1967;Forbes et al, 1967;Barker et al, 1968;Oyama and Takiguchi, 1970).…”

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confidence: 99%