A comparison of physiological and behavioural parameters in C57BL/6J mice undergoing food or water restriction regimes

Tucci, Valter; Hardy, Andrea; Nolan, Patrick M.

doi:10.1016/j.bbr.2006.05.031

Cited by 55 publications

(49 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since these authors were not specifically interested in induced restriction they, like many others, did not include ad libitum controls against which the restriction effects might have been observed. Similar results were obtained by Tucci et al (2006) for females of one inbred mouse strain (C57BL6/J). Fluid-controlled mice appeared to cope well with only 2 or 4 h ad libitum access to water per day and their recovery during the ad libitum period was more efficient as the days progressed, while food-controlled mice tended to lose weight progressively over the course of the study, although their weight rarely fell below 85% free fed weight.…”

Section: Animal Welfare Considerationssupporting

confidence: 87%

“…Depending on the manner in which they are implemented, controls of food and fluid can elicit physiological and behavioural responses in animals, potentially compromising their health and well-being (Kutscher, 1969;Hamilton and Flaherty, 1973;Albee et al, 1987;Levin et al, 1993;Heiderstadt et al, 2000;Toth and Gardiner, 2000;National Research Council, 2003a;Tucci et al, 2006;Rowland, 2007). Food or fluid control may also have an indirect impact on animal welfare if it affects husbandry (e.g.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: Report of a Working Group of the NC3Rs

Prescott

Brown

Flecknell

et al. 2010

Journal of Neuroscience Methods

View full text Add to dashboard Cite

This report provides practical guidance on refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research. The guidance is based on consideration of the scientific literature and, where data are lacking, expert opinion and professional experience, including that of the members of a Working Group convened by the United Kingdom National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). The report should be useful to researchers, veterinarians and animal care staff responsible for the welfare of macaques used in food and fluid control protocols, as well as those involved with designing, performing and analysing studies that use these protocols. It should also assist regulatory authorities and members of local ethical review processes or institutional animal care and use committees concerned with evaluating such protocols. The report provides a framework for refinement that can be tailored to meet local requirements. It also identifies data gaps and areas for future research and sets out the Working Group's recommendations on contemporary best practice.

show abstract

Section: Animal Welfare Considerationssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: Report of a Working Group of the NC3Rs

Prescott

Brown

Flecknell

et al. 2010

Journal of Neuroscience Methods

View full text Add to dashboard Cite

show abstract

“…Bfc/+ (n = 12) and +/+ (n = 12) mice were subjected to a 1-hour training session in a classical operant chamber every day for 8 consecutive working days as previously described (40). A central-hole LED and a 60-dB background white noise signalled the beginning of each trial.…”

Section: Timing Learningmentioning

confidence: 99%

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Tucci¹,

Kleefstra²,

Hardy³

et al. 2014

J. Clin. Invest.

120

128

View full text Add to dashboard Cite

The recent identification of multiple dominant mutations in the gene encoding β-catenin in both humans and mice has enabled exploration of the molecular and cellular basis of β-catenin function in cognitive impairment. In humans, β-catenin mutations that cause a spectrum of neurodevelopmental disorders have been identified. We identified de novo β-catenin mutations in patients with intellectual disability, carefully characterized their phenotypes, and were able to define a recognizable intellectual disability syndrome. In parallel, characterization of a chemically mutagenized mouse line that displays features similar to those of human patients with β-catenin mutations enabled us to investigate the consequences of β-catenin dysfunction through development and into adulthood. The mouse mutant, designated batface (Bfc), carries a Thr653Lys substitution in the C-terminal armadillo repeat of β-catenin and displayed a reduced affinity for membrane-associated cadherins. In association with this decreased cadherin interaction, we found that the mutation results in decreased intrahemispheric connections, with deficits in dendritic branching, long-term potentiation, and cognitive function. Our study provides in vivo evidence that dominant mutations in β-catenin underlie losses in its adhesion-related functions, which leads to severe consequences, including intellectual disability, childhood hypotonia, progressive spasticity of lower limbs, and abnormal craniofacial features in adults. Introduction β-Catenin (CTNNB1) is a highly conserved protein that implements key cellular functions by interacting with cell-adhesion proteins, signaling molecules, and transcription factors (1). The characteristic structural feature of the β-catenin protein, its 12 central armadillo repeats, forms a long positively charged groove facilitating interaction with multiple protein partners. This central motif is flanked by the N terminus, crucial in mediating degradation of the protein, and the C terminus, containing the Helix-C motif (2), which enables switching between the protein's dual roles in cell adhesion and proliferation. Loss-of-function studies in mammals have implicated β-catenin in embryonic development, while gain-of-function studies have demonstrated its contribution to various forms of human cancers (reviewed in ref.3). Functional investigation has focused on the role of β-catenin in canonical WNT signaling. β-Catenin interacts with transcriptional coactivators to mediate WNT's transcriptional activation, which orchestrates growth and patterning in the developing embryo, and, when constitutively upregulated, dysregulates growth connected to cancer and metastasis.

show abstract

“…Fasting or caloric restriction is a challenge, especially for small endothermic animals, and it significantly affects their physiology and behavior (Overton and Williams, 2004;Sakurada et al, 2000;Tucci et al, 2006). During fasting or prolonged food restriction in mice, heart rate, blood pressure, oxygen consumption and pulse are reduced gradually with increasing duration of negative energy balance (Swoap and Gutilla, 2009;Williams et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Specialist-generalist model of body temperature regulation can be applied on the intraspecific level

Przybylska

Boratyński

Wojciechowski

et al. 2017

Journal of Experimental Biology

View full text Add to dashboard Cite

According to theoretical predictions, endothermic homeotherms can be classified as either thermal specialists or thermal generalists. In high cost environments, thermal specialists are supposed to be more prone to using facultative heterothermy than generalists. We tested this hypothesis at the intraspecific level using male laboratory mice (C57BL/cmdb) fasted under different thermal conditions (20 and 10°C) and for different time periods (12-48 h). We predicted that variability of body temperature (T b ) and time spent with T b below normothermy would increase with the increase of environmental demands (duration of fasting and cold). To verify the above prediction, we measured T b and energy expenditure of fasted mice. We did not record torpor bouts but we found that variations in T b and time spent in hypothermia increased with environmental demands. In response to fasting, mice also decreased their energy expenditure. Moreover, animals that showed more precise thermoregulation when fed had more variable T b when fasted. We postulate that the prediction of the thermoregulatory generalist-specialist trade-off can be applied at the intraspecific level, offering a valid tool for identifying mechanistic explanations of the differences in animal responses to variations in energy supply.

show abstract

A comparison of physiological and behavioural parameters in C57BL/6J mice undergoing food or water restriction regimes

Cited by 55 publications

References 23 publications

Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: Report of a Working Group of the NC3Rs

Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: Report of a Working Group of the NC3Rs

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Specialist-generalist model of body temperature regulation can be applied on the intraspecific level

Contact Info

Product

Resources

About