A comparison of perinephric fat surface area and Mayo Adhesive Probability score in predicting malignancy in T1 renal masses

Bernstein, Ari P.; Fram, Ethan; Sankin, Alexander; Kovac, Evan; Srivastava, Abhishek; DiVito, Joseph; Stern, Joshua M.

doi:10.1016/j.urolonc.2018.07.018

Cited by 4 publications

(8 citation statements)

References 33 publications

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“…Different male to female ratios between the two groups should also be highlighted, as it is suggested that males have a greater amount of perinephric fat compared with females. 7,8,44 Although small sample size was a limitation, an increased perinephric fat volume was not observed in male patients with benign renal tumours in the present study. Further investigations on a larger scale may be required to verify the present results.…”

Section: Discussioncontrasting

confidence: 55%

“…Bernstein et al. 8 concluded that, instead of PFA, fat adhesiveness is predictive of malignant histology. However, the quantitative influence of adjacent adipose tissue may not be fully elucidated, as studies regarding epicardial fat and coronary artery disease have suggested.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are reports that pure quantitative measurement of perinephric fat area (PFA) fails to predict the malignant pathology of renal tumours. 7,8 Compared with one-dimensional fat thickness or two-dimensional PFA, threedimensional perinephric fat volume (PFV) may more accurately describe the amount of perinephric adipose tissue and its relationship with renal tumours. An increased PFV has been shown to influence the complexity of robotic-assisted partial nephrectomy with a significantly increased operation time, while MAP score was not a significant predictor.…”

Section: Introductionmentioning

confidence: 99%

“…The Mayo Adhesive Probability (MAP) score is a 0 to 6 scoring system composed of perinephric fat thickness (PFT) and fat stranding quality. 7 , 8 Although the MAP score was originally developed for preoperative prediction of partial nephrectomy, it has also been associated with malignant renal histology. However, there are reports that pure quantitative measurement of perinephric fat area (PFA) fails to predict the malignant pathology of renal tumours.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are reports that pure quantitative measurement of perinephric fat area (PFA) fails to predict the malignant pathology of renal tumours. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

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Comparison of perinephric fat measurements between malignant and benign renal tumours

et al. 2022

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Objective To investigate different parameters derived from the quantity and quality of perinephric fat, and to compare their effectiveness in predicting the malignant pathology of renal tumours. Methods Data from patients diagnosed with renal tumour between April 2014 and December 2020 were retrospectively reviewed, and patients were categorized into malignant or benign tumour groups. Fat parameters, including perinephric fat volume (PFV), perinephric fat area (PFA), perinephric fat thickness (PFT), and Mayo adhesive probability (MAP) score were measured using abdominal computed tomography scans. Between-group differences were assessed by analysis of variance and χ2-test. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the performance of perinephric fat parameters in diagnosing malignancy. Results A total of 109 patients were included. MAP score, PFV, PFA, and PFT were significantly increased in the malignant versus benign tumour group, and after correction for body mass index (BMI), the indexed PFV/BMI, PFA/BMI, and PFT/BMI values remained significantly higher in the malignant tumour group. All parameters showed fair predictivity of malignancy, with comparable area under the curve values in the ROC curve. Conclusion An increased amount of perinephric fat is predictive of malignant pathology for renal tumours. The predictive accuracy for each perinephric fat parameter remained fair after correcting for BMI.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, there are reports that pure quantitative measurement of perinephric fat area (PFA) fails to predict the malignant pathology of renal tumours. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

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Comparison of perinephric fat measurements between malignant and benign renal tumours

et al. 2022

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Association between CT-based adipose variables, preoperative blood biochemical indicators and pathological T stage of clear cell renal cell carcinoma

Sun,

Zhang,

Xia

et al. 2024

Heliyon

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Relationship Between Adherent Perinephric Fat and Sex Hormone Levels in Serum and Fat in Patients Undergoing Robotic-Assisted Partial Nephrectomy: A Prospective Study

et al. 2023

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Background: Perinephric fat removal is essential for safe and effective robotic-assisted partial nephrectomy (RAPN). Adherent perinephric fat (APF) occasionally compromises RAPN, but the relationship between such fat and sex hormone levels is unclear. We explored a possible association between APF and sex hormone levels in serum and APF tissue. Patients and Methods: We conducted a prospective study from 2021 to 2022 at Gunma University Hospital. Fifty patients treated using RAPN were analyzed. We measured the testosterone (T) and estradiol (E) levels in serum and perinephric fat using liquid chromatography-mass spectrometry (LC-MS/MS). The correlations between the extent of adherence measured intraoperatively and hormone concentrations were examined. Results: Of the 50 cases, 36 were male, and 14 were female. APF was observed in 16 of the male patients but in no female patients. In male patients, the T levels in perinephric fat were significantly higher in patients with APF. E2 levels in perinephric fat tissue were also significantly higher in patients with APF. Conclusion: In the 36 male patients lacking APF, there were no significant differences in the serum levels of T compared with those with APF, but a significant difference was apparent in APF tissue. The changed T level in APF tissue may have affected APF development.

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A comparison of perinephric fat surface area and Mayo Adhesive Probability score in predicting malignancy in T1 renal masses

Cited by 4 publications

References 33 publications

Comparison of perinephric fat measurements between malignant and benign renal tumours

Comparison of perinephric fat measurements between malignant and benign renal tumours

Association between CT-based adipose variables, preoperative blood biochemical indicators and pathological T stage of clear cell renal cell carcinoma

Relationship Between Adherent Perinephric Fat and Sex Hormone Levels in Serum and Fat in Patients Undergoing Robotic-Assisted Partial Nephrectomy: A Prospective Study

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