A comparison of pentamorphone and fentanyl in balanced anaesthesia during general surgery

Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs

“…However, all potent and common analgesic drugs used decrease the anesthetic MAC requirements in dogs and humans. [28][29][30][31][32][33] Thus, MAC determination can be used to test the response to different drugs during a painful or noxious stimulus. If a particular drug reduces the MAC, further studies are required to determine the true analgesic effect of the drug in awake subjects.…”

A dog model to study ovary, ovarian ligament and visceral pain

“…Thus, MAC is not considered the best method to assess analgesia but rather is the anesthetic requirement to prevent the response to a painful/noxious challenge. However, all potent and common analgesic drugs used in medicine decrease the MAC in dogs and humans (Murphy & Hug 1982;McEwan et al 1993;Kelly et al 1994;Eger et al 2003;Machado et al 2006;Ko et al 2009). Thus, MAC determination can be used to test the response of different drugs during a painful/ noxious stimulus.…”