A comparison of pediatric, adolescent, and adult testicular germ cell malignancy

Cost, Nicholas G.; Lubahn, Jessica D.; Adibi, Mehrad; Romman, Adam; Wickiser, Jonathan E.; Raj, Ganesh V.; Sagalowsky, Arthur I.; Margulis, Vitaly

doi:10.1002/pbc.24773

Cited by 44 publications

(27 citation statements)

References 27 publications

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“…(13)(14)(15)(16)(17)(18)(19) years) compared to either children or adults, with 3-year EFS of 59.9%, 87.2%, and 80.0%, respectively (P = 0.011); nevertheless, survival was not statistically different among the 3 groups. 28 We have not found the ''gap'' in EFS in the current series, even if outcomes were slightly inferior in the 11 to 17 population, compared to younger and older groups.…”

Section: Discussioncontrasting

confidence: 71%

Ovarian Yolk Sac Tumors; Does Age Matter?

Conter

Xia

Gershenson

et al. 2018

Int J Gynecol Cancer

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Section: Discussioncontrasting

confidence: 71%

Ovarian Yolk Sac Tumors; Does Age Matter?

Conter

Xia

Gershenson

et al. 2018

Int J Gynecol Cancer

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“…The incidence of TGCT is higher among whites and Hispanics than among blacks (Table ). Nonseminomas are more common than seminomas among adolescent boys; nonseminoma germ cell tumors are divided into 4 subtypes (choriocarcinoma, yolk sac, embryonal carcinoma, and teratoma), and approximately 60% contain more than one of these histologic patterns . A lump on the testicle is usually the first sign and often leads to diagnosis at an early stage.…”

Section: Information For Selected Cancer Sitesmentioning

confidence: 99%

Childhood and adolescent cancer statistics, 2014

Ward

DeSantis

Robbins

et al. 2014

CA A Cancer J Clinicians

1,992

1,564

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In this article, the American Cancer Society provides estimates of the number of new cancer cases and deaths for children and adolescents in the United States and summarizes the most recent and comprehensive data on cancer incidence, mortality, and survival from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries (which are reported in detail for the first time here and include high-quality data from 45 states and the District of Columbia, covering 90% of the US population). In 2014, an estimated 15,780 new cases of cancer will be diagnosed and 1960 deaths from cancer will occur among children and adolescents aged birth to 19 years. The annual incidence rate of cancer in children and adolescents is 186.6 per 1 million children aged birth to 19 years. Approximately 1 in 285 children will be diagnosed with cancer before age 20 years, and approximately 1 in 530 young adults between the ages of 20 and 39 years is a childhood cancer survivor. It is therefore likely that most pediatric and primary care practices will be involved in the diagnosis, treatment, and follow-up of young patients and survivors. In addition to cancer statistics, this article will provide an overview of risk factors, symptoms, treatment, and long-term and late effects for common pediatric cancers.

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“…Additionally, even in the malignant prepubertal tumors only 5% of the prepubertal YSTs are metastatic at presentation, compared with 20% to 30% of postpubertal GCTs [22]. Further evidence of the aggressive and unique nature of adolescent patients with TGCTs is that although 85% of prepubertal patients present with Stage I disease only 33% of postpubertal adolescents present with localized disease [18,23].…”

Section: Prepubertal Vs Postpubertal Tumorsmentioning

confidence: 92%

“…However, there is increasing recognition that the 15-to 19-year-old age group has different outcomes than those of the 0-to 14-year-old group [17]. A recent institutional review of adolescent patients with TGCT suggesting a decreased event-free survival in adolescents when compared with either pediatric or adult patients demonstrates further support for adolescent disease being considered distinctly [18].…”

Section: Prepubertal Vs Postpubertal Tumorsmentioning

confidence: 93%