A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

Kim, Nan Seol; Kang, Kyu-Suk; Yoo, Sun Hong; Chung, Ji Won; Seo, Yonghan; Chung, Ho Soon; Jeon, Hye Rim; Gong, Hyung Youn; Lee, Hyun Young; Mun, Seong Taek

doi:10.4097/kjae.2015.68.3.261

Cited by 30 publications

(46 citation statements)

References 14 publications

(24 reference statements)

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“…[19] In a study of 60 laparoscopic hysterectomy, patients were randomized to receive PCA oxycodone or PCA fentanyl (potency ratio 100:1) following surgery find that oxycodone presented a better analgesic effect, also resulted in a higher occurrence of postoperative nausea and vomiting. [20] In another recent similar study, the potency ratio was 60:1, and both agents were found to provide similar analgesic efficacy and similar rates of adverse events. [21] Overall, the potency ratio of fentanyl to morphine has a range of 60–100:1.…”

Section: Discussionmentioning

confidence: 99%

“…First, it has been demonstrated that oxycodone produced similar or less sedation compared to fentanyl in several recent studies. [18,20,21] In addition, median doses of opioid consumed 30 minutes postsurgery was oxycodone 3.5 mg (range: 2.4–5.4 mg) and fentanyl 64 μg (range: 49–120 μg), this meant to be relatively few oxycodone consumption during this time period.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and tolerability of oxycodone versus fentanyl for intravenous patient-controlled analgesia after gastrointestinal laparotomy

Ding

Wang

et al. 2016

Medicine

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Background:It has been suggested that oxycodone is effective in relieving acute postoperative pain. The aim of this study was to investigate the efficacy and tolerability of oxycodone (O) versus fentanyl (F), and the adequate potency ratio of oxycodone and fentanyl in patients with intravenous patient-controlled analgesia after gastric laparotomy.Methods:In this double-blinded, randomized, controlled study, 60 patients undergoing elective gastric laparotomy were allocated to receive either oxycodone or fentanyl for postoperative intravenous patient-controlled analgesia (potency ratio 60:1). The patients received ketorolac 60 mg before the end of anesthesia and then continued with patient-controlled analgesia for 48 hours postsurgery. Pain severity, side effects and respiration rate were recorded 30 minutes, 3, 6, 12, 24, and 48 hours after the surgery. Cumulative opioid requirements and patient satisfaction were also measured.Results:The median consumption more than 48 hours after operation of oxycodone was 50 mg (range: 40.0–62.4 mg) and fentanyl was 0.8 mg (range: 0.6–1.1 mg), and the percentage of patients requiring rescue medication was not statistically significant. Numeric rating scores at rest and upon movement were significantly lower in group O than in F (P < 0.05). Whereas the incidences of adverse events were similar between the groups (33.3% vs 27.6%, P = 0.64), a significant higher sedation scores were found in patients given fentanyl at 30 minutes after the surgery (P = 0.04).Conclusion:Oxycodone was comparable to fentanyl in the relief of postoperative pain following gastric laparotomy. Oxycodone not only provides better postoperative pain relief and less sedation, but also there was a tendency toward more side effects with oxycodone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of oxycodone versus fentanyl for intravenous patient-controlled analgesia after gastrointestinal laparotomy

Ding

Wang

et al. 2016

Medicine

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“…Previous studies have shown that the potency ratio of oxycodone to morphine is 1:1, whereas the potency ratio of morphine to fentanyl is 100:1 . Two studies comparing patient‐controlled oxycodone and fentanyl in patients who underwent laparoscopic cholecystectomy and hysterectomy showed that the cumulative oxycodone dose was lower than the cumulative fentanyl dose . Moreover, a study comparing patient‐controlled oxycodone and fentanyl in patients undergoing laparoscopic hysterectomy or myomectomy showed that, when the potency ratio of oxycodone to fentanyl was 60:1, the two opioids had similar analgesic effects .…”

Section: Discussionmentioning

confidence: 99%

Comparison of the analgesic effect of patient‐controlled oxycodone and fentanyl for pain management in patients undergoing colorectal surgery

Jung

Kang

Park

et al. 2016

Clin Exp Pharma Physio

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Oxycodone is a μ-opioid receptor agonist and is generally indicated for the relief of moderate to severe pain. The aim of this study was to compare the analgesic efficacy of patient-controlled oxycodone and fentanyl for postoperative pain in patients undergoing colorectal surgery. Patients scheduled to undergo elective colorectal surgery (n=82) were allocated to receive oxycodone (n=41, concentration of 1 mg/mL) or fentanyl (n=41, concentration of 15 μg/mL) for postoperative pain management. After the operation, pain using a numerical rating scale (NRS), delivery to demand ratio, infused dose of patient-controlled analgesia (PCA), side effects, and sedation levels were evaluated. Median (25%-75%) cumulative PCA dose of oxycodone group at 48 hours (66.9, 58.4-83.7 mL) was significantly less than that of fentanyl group (80.0, 63.4-103.3 mL, P=.037). Six hours after surgery, the mean (SD) NRS scores of the oxycodone and fentanyl groups were 6.2 (2.4) and 6.8 (1.9), respectively (P=.216). The mean equianalgesic potency ratio of oxycodone to fentanyl was 55:1. The groups did not differ in postoperative nausea, vomiting, and level of sedation. Patient-controlled oxycodone provides similar effects for pain relief compared to patient-controlled fentanyl in spite of less cumulative PCA dose. Based on these results, oxycodone can be a useful alternative to fentanyl for PCA in patients after colorectal surgery.

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“…Fentanyl is an opioid with the short onset and action duration, and has been commonly administered prior to intubation [4]. Oxycodone is a strong mu-opioid receptor agonist and its potency is also similar to that of morphine [5].…”

Section: Introductionmentioning

confidence: 99%

Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone

et al. 2016

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BackgroundThe present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture.MethodsIn this prospective randomized double-blinded study, 64 patients undergoing closed reduction of nasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone group (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered prior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative pain were then measured in both groups.ResultsThere was no significant difference in the change in mean arterial pressure and heart rate between pre-induction and post-intubation in both Groups F and O (P > 0.05). Postoperative pain in Group O was milder than that in Group F (P < 0.001); however, time to awakening from the end of operation was shorter in Group F (P = 0.012).ConclusionIn patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic response to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl in improving postoperative pain.Trial registrationClinical Research Information Service (Trial registry number: KCT0001153) on 3 July, 2014Electronic supplementary materialThe online version of this article (doi:10.1186/s12871-016-0279-x) contains supplementary material, which is available to authorized users.

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A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

Cited by 30 publications

References 14 publications

Efficacy and tolerability of oxycodone versus fentanyl for intravenous patient-controlled analgesia after gastrointestinal laparotomy

Efficacy and tolerability of oxycodone versus fentanyl for intravenous patient-controlled analgesia after gastrointestinal laparotomy

Comparison of the analgesic effect of patient‐controlled oxycodone and fentanyl for pain management in patients undergoing colorectal surgery

Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone

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