A comparison of organochlorine residues in human adipose tissue autopsy samples from two Ontario municipalities

Abstract

Human adipose tissue samples obtained during autopsies in a Canadian Great Lakes community, Kingston, Ontario, and a second community, Ottawa, Ontario, were analyzed for organochlorine pesticides, polychlorobiphenyls, chlorobenzenes, and chlorophenols. Significantly different levels of Dichlorodiphenyl -dichloroethane, mirex, hexachlorobenzene, and 2,3,4,6-tetrachlorophenol were found in Kingston adipose tissues compared to Ottawa tissues. Residue levels of oxychlordane , mirex, and polychlorinated biphenyls were significantly different in Kingston males versus Kingston females. The means and ranges of residue levels were contrasted with those reported in previous Canadian surveys.

Atsdr Evaluation of Health Effects of Chemicals

“…A subsequent 1984 study examined mirex levels in six additional cities on the Canadian portion of Lake Ontario. The overall mean mirex residue in human adipose tissue was 11 ± 13 ng/g (ppb) (males, 12 ± 15 ng/g; females, 9.6 ± 10 ng/g) (Williams et al, 1988b).…”

“…Males from Kingston had significantly higher levels of mirex (38 ng/g) than females from the area (12 ng/g); this gender difference was not explained or seen in the Ottawa samples (Williams et al, 1984). A subsequent 1984 study examined mirex levels in six additional cities on the Canadian portion of Lake Ontario.…”

Residues of Selected Polychlorinated Biphenyls (PCB) and Organochlorine Pesticides (OCP) in Postmortem Lungs From Epirus, Northwestern Greece

“…OC levels in tissues from living individuals, besides serum, breast milk, and hair, that could be obtained only by invasive procedures or during surgery (Esteban and Castano, 2009) have been reported in limited studies. It is worthwhile noting that most relevant studies performed on autopsy specimens (Williams et al, 1984;Mussalo-Rauhamma, 1991;Kemper, 1993;Galleli et al, 1995;Weistrand and Noren, 1998;Ben-Michael et al, 1999;Dewailly et al, 1999;Corrigan et al, 2000;Chu et al, 2003;Waliszewski et al, 2004), and levels of pollutants detected in the different tissues may be considered indicative of accumulation of compounds in humans.…”

“…In this study, the presence of OC including PCB, γ-HCH, and p,p'-DDE may reflect their chronic potential to accumulate in human lung tissue. Nevertheless, the presence of OC in different human autopsy tissues, such as adipose tissue (Williams et al, 1984;Mussalo-Rauhamma, 1991;Gallelli et al, 1995;Weistrand et al, 1998;Dewailly et al, 1999;Chu et al, 2003;Li et al, 2006b), liver (Mussalo-Rauhamma, 1991Gallelli et al, 1995;Weistrand et al, 1998;Dewailly et al, 1999;Chu et al, 2003), brain (Corrigan et al, 2000;Dewailly et al, 1999), muscle (Li et al, 2006b), and lung (herein), might be the result of accumulation of these compounds in human tissues and their concentrations may reflect the body burden of these compounds.…”

Sorption and Desorption Behaviors of Chlorobenzene on the Sediment of Songhua River

“…MCB exists in general environment and human tissue [2][3][4] .It belongs to hydrophobic organic compounds, and the octanol/water partition coefficient is 2.98. Sorption and desorption behaviors on sediment of MCB were an important process on the transfer, degradation, transformation and fate in water environment.…”