A comparison of NAFLD and MAFLD diagnostic criteria in contemporary urban healthy adults in China: a cross-sectional study

Liu, Qiling; Zhao, Gang; Li, Qian; Wu, Wanlong; Zhang, Yan; Bian, Hua

doi:10.1186/s12876-022-02576-4

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…7 Recent studies have shown that the criteria for MAFLD are more accurate in identifying patients with high risk of fatty liver disease compared to the NAFLD criteria. [8][9][10] Therefore, the impact of metabolic dysfunction on the natural progression of liver diseases such as chronic viral hepatitis or alcoholic hepatitis is studied using the MAFLD criteria. 4 In the western countries, MAFLD is one of the leading causes of end-stage liver disease, cirrhosis, and hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Chinese Visceral Adipose Index Shows Superior Diagnostic Performance in Predicting the Risk of Metabolic Dysfunction Associated Fatty Liver Disease in Early Postmenopausal Chinese Women

Lu¹,

Ge²,

Yang³

et al. 2023

DMSO

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Background: Previous studies have reported the diagnostic values of multiple obesity indicators for predicting the risk of nonalcoholic fatty liver disease. However, the diagnostic values of obesity indicators for predicting the risk of metabolic dysfunctionassociated fatty liver disease (MAFLD) in early postmenopausal women is still unknown. Therefore, this study investigated the predictive values of common obesity indices for estimating the risk of MAFLD in early postmenopausal Chinese women. Methods: This study enrolled 2514 early postmenopausal women, aged between 45 and 55 years, who underwent abdominal ultrasonography examination at the Health examination center of the Huadong Sanatorium between June 2021 and December 2021. The values for six obesity indices, namely, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-toheight ratio (WHtR), body adiposity index (BAI), and Chinese visceral adiposity index (CVAI) were extracted from the medical records. Results: Our data showed that all the six obesity indices were significantly associated with the risk of MAFLD (P < 0.05) in the obese subjects and five obesity indices except for BAI were significantly associated with the risk of MAFLD (P < 0.05) in the lean subjects. The six obesity indices showed a linear relationship with the risk of MAFLD (all P-values > 0.05). The ORs for the obesity indices with the exception of BAI showed proportional increase with the risk of MAFLD in the lean subjects. CVAI was the strongest predictor of the risk of MAFLD in both lean (AUC=0.868) and overweight/obese subjects (AUC=0.704) among the early postmenopausal women. Conclusion:This study demonstrated that all the obesity indices were associated with an increased risk of MAFLD in the obese subjects and five obesity indices except for BAI were associated with an increased risk of MAFLD in the lean subjects among the early postmenopausal women. CVAI showed the strongest predictive performance in estimating the risk of MAFLD among early menopausal women.

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Section: Introductionmentioning

confidence: 99%

Chinese Visceral Adipose Index Shows Superior Diagnostic Performance in Predicting the Risk of Metabolic Dysfunction Associated Fatty Liver Disease in Early Postmenopausal Chinese Women

Lu¹,

Ge²,

Yang³

et al. 2023

DMSO

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“…As NAFLD and MAFLD highly overlap (21), the results of this study may have been similar to those of a previous study on AIH patients with NAFLD. Previous reports have shown that MAFLD is more likely to progress to liver fibrosis than NAFLD is (22)(23)(24). Therefore, further studies are needed to reveal the differences in the impact of NAFLD and MAFLD on AIH.…”

Section: Discussionmentioning

confidence: 96%

Autoimmune Hepatitis with Metabolic Dysfunction-associated Fatty Liver Disease

Takahashi,

Ohira,

Abe

et al. 2024

Intern. Med.

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Objective Metabolic-associated fatty liver disease (MAFLD) has only recently been proposed; therefore, the characteristics of patients with autoimmune hepatitis (AIH) and MAFLD remain unclear. This study evaluated the effect of MAFLD on AIH patients with AIH. Methods We reevaluated the Japanese Nationwide Survey of AIH in 2018, which involved a survey of patients diagnosed with AIH between 2014 and 2017. We categorized patients with AIH according to the presence or absence of MAFLD and compared the clinical characteristics between the two groups. Results A total of 427 patients (77 men and 350 women) were included in this study. The overall prevalence of MAFLD was 10.5%. Compared to AIH patients without MAFLD, AIH patients with MAFLD had the following characteristics at the time of the AIH diagnosis: (1) a higher body mass index, (2) a higher prevalence of hypertension, (3) mild elevation of hepatobiliary enzymes and total bilirubin, and (4) histologically progressive fibrosis. However, the levels of hepatobiliary enzymes and total bilirubin after treatment were significantly higher in AIH patients with MAFLD than in those without MAFLD. Conclusions AIH patients with MAFLD had characteristics different from those of AIH patients without MAFLD. These findings could help increase our understanding of patients with AIH with MAFLD.

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“…Due to recent changes in the nomenclature, MASLD covers a broad spectrum of pathological changes in liver parenchyma regarding hepatic steatosis [17,18]. Compared to previous NAFLD or MAFLD nomenclature and the fact that some patients might have average values of liver enzymes as being routinely checked in primary healthcare until ultrasound is used to spot specific parenchymal steatotic changes, the use of MASLD criteria increases the pool of T2DM patients being leaned towards metabolic illness [1,17].…”

Section: Discussionmentioning

confidence: 99%

Adipocytokines as Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development in Type 2 Diabetes Mellitus Patients

Fajkić,

Jahić,

Hadžović-Džuvo

et al. 2024

Cureus

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Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition. Due to pathophysiological processes, MASLD's relation to type 2 diabetes mellitus (T2DM) is still unclear, especially when the role of adipocytokines is taken into consideration. Objective: This study aims to examine the potential predictive value of adiponectin and resistin for MASLD in T2DM. Patients and methods: In a two-year study, 71 T2DM patients were categorized into MASLD-T2DM and non-MASLD-T2DM groups according to MASLD development. Serum samples were tested for resistin, adiponectin, high-density lipoprotein cholesterol, fasting glucose, and triglycerides. An appropriate equation is used to calculate the adiponectin/resistin (A/R) index. The optimal cut-off values for differentiating MASLD patients from non-MASLD patients were determined using receiver operating characteristic (ROC) curves and the corresponding areas under the curve (AUC). To predict the onset of MASLD in patients with T2DM, a logistic regression analysis was performed. Results: There were significant differences in adiponectin (p<0.001), resistin (p<0.001), and A/R index (p<0.001) between T2DM individuals with and without MASLD. The ROC curve for resistin produced an AUC of 0.997 (p<0.001) with a sensitivity of 96.1% and a specificity of 100% for the cut-off point of 253.15. Adiponectin (OR, 0.054; 95% CI, 0.011-0.268; p<0.001) and resistin (OR, 1.745; 95% CI, 1.195-2,548; p=0.004) were found to be independent predictors for MASLD by logistic regression analysis. Conclusion: This study confirms the potential of adiponectin and resistin as predictors of MASLD development in T2DM.

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A comparison of NAFLD and MAFLD diagnostic criteria in contemporary urban healthy adults in China: a cross-sectional study

Cited by 6 publications

References 38 publications

Chinese Visceral Adipose Index Shows Superior Diagnostic Performance in Predicting the Risk of Metabolic Dysfunction Associated Fatty Liver Disease in Early Postmenopausal Chinese Women

Chinese Visceral Adipose Index Shows Superior Diagnostic Performance in Predicting the Risk of Metabolic Dysfunction Associated Fatty Liver Disease in Early Postmenopausal Chinese Women

Autoimmune Hepatitis with Metabolic Dysfunction-associated Fatty Liver Disease

Adipocytokines as Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development in Type 2 Diabetes Mellitus Patients

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