A comparison of midazolam and diazepam for conscious sedation during colonoscopy in a prospective double-blind study

Zakko, Salam; Seifert, Harry A.; Gross, Jeffrey B.

doi:10.1016/s0016-5107(99)70282-8

Cited by 60 publications

(45 citation statements)

References 13 publications

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“…In comparative studies with diazepam in several procedures, midazolam proved more effective at inducing rapid sedation. 16,[18][19][20] Midazolam is known to be rapidly absorbed and the onset of action is, therefore, faster than that of diazepam and its effects are expected to occur sooner than those of diazepam. In addition, the dose of both drugs to reach adequate sedation was similar.…”

Section: Discussionmentioning

confidence: 99%

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Diazepam or midazolam for orotracheal intubation in the ICU?

Gehrke

Oliveira

Becker³

et al. 2015

Rev. Assoc. Med. Bras.

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Section: Discussionmentioning

confidence: 99%

“…6,16,17 The awakening time is considerably longer for midazolam so that any time gained with induction of sedation is lost in the longer recovery. 15,16,[18][19][20] However, most patients that need urgent intubation in the ICU will need continuous sedation, mainly due to respiratory insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Diazepam or midazolam for orotracheal intubation in the ICU?

Gehrke

Oliveira

Becker³

et al. 2015

Rev. Assoc. Med. Bras.

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“…The efficacy of sedation with these 2 benzodiazepines is comparable [26]. However, there is a known favor on midazolam due to minimal risk of venous irritation and phlebitis resulting in painless İ.V.…”

Section: Benzodiazepinsmentioning

confidence: 99%

Sedation for Esophagogastroduodenal Endoscopy

Aydın¹

2011

Ann Clin Anal Med

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ÖzetÖzefagogastroduedonal endoskopi sırasında pek çok anestetik yöntem ve ilaç kullanılabilir. Özefagogastroduedonal endoskopi için uygulanacak sedasyon ilaç ve yöntemleri hakkında araştırmalar sürmektedir. Bu derlemenin amacı sedasyon ve özefagogastroduedonal endoskopi ve sedasyonla ilişkili konuları literature bilgileri ışığında tartışmaktır. Tanısal özefagogastroduedonal endoskopi için günü-müzde kullanılan standart yöntem genellikle yüzeyel farengeal anestezi minimal sedasyon ya da anksiyolizdir. Gerekli olursa sonradan analjezi eklenebilir. Uzun süreli, karmaşık ya da sorunlu ve ağrılı işlemler için uzman denetiminde yapılan daha derin sedasyon yöntemleri gerekebilir. Anahtar KelimelerEndoskopi; Gastrointestinal Endoskopi; Sedasyon Abstract Different anesthetic techniques and drugs can be used for esophagogastroduedonal endoscopy. However, the scientists are still searching for appropriate drugs and protocols for sedation during esophagogastroduedonal endoscopy. The aim of this review is to discuss the topics related with sedation and esophagogastroduedonal endoscopy in the light of literature. Today standard procedure for diagnostic esophagogastroduedonal endoscopy usually consists of topical pharyngeal anesthesia, minimal sedation or anxiolysis, which may be complemented with analgesia when needed. When a prolonged, complex, or particularly troublesome or painful examination is foreseen, deeper sedation with multiple drugs and in closed observation of a staff may be required.

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“…Zakko et al (778) showed that midazolam was more than three times as potent as diazepam in decreasing the level of consciousness and causing respiratory depression. Even when midazolam is given slowly rather than as a bolus, the maximum depression of the ventilatory CO 2 response is profound (278).…”

Section: Benzodiazepinesmentioning

confidence: 99%

Effects of Anesthetics, Sedatives, and Opioids on Ventilatory Control

Stuth

Stucke

Zuperku

2012

Comprehensive Physiology

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This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de-emphasized or excluded.

show abstract

A comparison of midazolam and diazepam for conscious sedation during colonoscopy in a prospective double-blind study

Cited by 60 publications

References 13 publications

Diazepam or midazolam for orotracheal intubation in the ICU?

Diazepam or midazolam for orotracheal intubation in the ICU?

Sedation for Esophagogastroduodenal Endoscopy

Effects of Anesthetics, Sedatives, and Opioids on Ventilatory Control

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