Engineered Conditioning (EC) is a Genetic Algorithm operator that works together with the typical genetic algorithm operators: mate selection, crossover, and mutation, in order to improve convergence toward an optimal multiple fault diagnosis. When incorporated within a typical genetic algorithm, the resulting hybrid scheme produces improved reliability by exploiting the global nature of the genetic algorithm as well as "local" improvement capabilities of the Engineered Conditioning operator.We show the significance of the Engineered Conditioning operator during Multiple Fault Diagnosis (i.e., finding the collection of simultaneously occurring disorders that best explains the observed symptoms or disorder manifestations). Within the Multiple Fault Diagnosis domain, we show the improvement of diagnostic reliability when using the engineered conditioning operator with the genetic algorithm compared to results from the genetic algorithm without the new operator. Reliability is based on the number of diagnostic trials for which the two versions of the genetic algorithm find the optimal diagnosis. For comparison purposes, optimal diagnoses have been computed using a search method that is guaranteed to find the optimal solution.