A comparison of live birth rates and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos

Ho, Jocelyn; Woo, Irene; Louie, Kristin; Salem, Wael; Jabara, S.; Bendikson, Kristin; Paulson, Richard J.; Chung, Karine

doi:10.1007/s10815-017-0995-2

Cited by 29 publications

(11 citation statements)

References 31 publications

(29 reference statements)

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“…The time in storage does not seem to affect the cycle outcome for either cryopreservation technique [ 29 , 90 , 91 ]. A retrospective cohort study [ 92 ] comparing outcomes of more than a thousand babies born from vitrified oocytes versus fresh oocytes suggested that oocyte vitrification does not increase adverse obstetric and perinatal outcomes nor congenital anomalies and complimented similar findings from previous smaller studies [ 28 , 93 , 94 ]. Of note, the proportion of female offspring was significantly higher in the vitrification group (53.8% vs. 47.4%).…”

Section: A Word Of Cautionsupporting

confidence: 61%

Elective oocyte cryopreservation for age-related fertility decline

Chronopoulou

Raperport

Sfakianakis

et al. 2021

J Assist Reprod Genet

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Purpose Women who pursue fertility at an advanced age are increasingly common. Family planning and sexual education have traditionally focused on contraception and prevention of sexually transmitted diseases. A focus should now also be placed on fertility awareness and fertility preservation. This manuscript aims to give an update on the existing evidence around elective oocyte cryopreservation, also highlighting the need for fertility education and evidence-based, individualized counselling. Methods A thorough electronic search was performed from the start of databases to March 2020 aiming to summarize the existing evidence around elective egg freezing, the logic behind its use, patient counselling and education, success rates and risks involved, regulation, cost-effectiveness, current status and future perspectives. Results Clinician-led counselling regarding reproductive aging and fertility preservation is often overlooked. Elective oocyte cryopreservation is not a guarantee of live birth, and the answer regarding cost-effectiveness needs to be individualized. The existing studies on obstetric and perinatal outcomes following the use of egg freezing are, until now, reassuring. Constant monitoring of short-term and long-term outcomes, uniform regulation and evidence-based, individualized counselling is of paramount importance. Conclusions Elective oocyte cryopreservation is one of the most controversial aspects of the world of assisted reproduction, and a lot of questions remain unanswered. However, women today do have this option which was not available in the past. Elective oocyte cryopreservation for age-related fertility decline should be incorporated in women’s reproductive options to ensure informed decisions and reproductive autonomy.

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Section: A Word Of Cautionsupporting

confidence: 61%

Elective oocyte cryopreservation for age-related fertility decline

Chronopoulou

Raperport

Sfakianakis

et al. 2021

J Assist Reprod Genet

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“…In women without a partner, outcomes of oocyte cryopreservation have improved significantly over the past decade such that they are now not significantly different compared to those of embryo cryopreservation. 101 Donor oocytes may also be a treatment option for women whose ovaries were either removed due to malignancy or who do not have sufficient oocytes for use with in-vitro fertilization but who desire to carry a pregnancy derived from her partner's sperm.…”

Section: Additional Techniques For Fertility Preservation In Eoc Patimentioning

confidence: 99%

Fertility‐sparing treatment for early‐stage epithelial ovarian cancer: Contemporary oncologic, reproductive and endocrinologic perspectives

Mandelbaum

Klar

Takiuchi

et al. 2020

J of Obstet and Gynaecol

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Aim Epithelial ovarian cancer (EOC) can be a devastating diagnosis in women of reproductive age who desire future fertility. However, in early‐stage disease, fertility‐sparing surgery (FSS) can be considered in appropriately selected patients. Methods This is a narrative descriptive review of the recent literature on FSS for EOC from oncologic, reproductive and endocrinologic perspectives. Results The recurrence rate following FSS performed for stage I EOC in published retrospective studies collectively is 13% but ranges from 5 to 29%, while mortality ranges from 0 to 18%. Five‐year disease‐free survival following FSS is over 90% but decreases with higher stage and grade. Recurrences following FSS are more likely to be localized with a more favorable prognosis compared to recurrences following radical surgery. Adjuvant chemotherapy is recommended in women with high‐risk disease, and strategies to minimize gonadotoxicity during chemotherapy such as gonadotropin‐releasing hormone (GnRH) agonists may be considered. Oocyte, embryo and/or ovarian cryopreservation can also be offered to patients desiring future biologic children. Reproductive outcomes following FSS, including pregnancy and miscarriage rates, resemble those of the general population, with a chance of successful pregnancy of nearly 80%. Conclusion In retrospective data, FSS appears to be oncologically safe in stage IA and IC grade 1–2 non‐clear cell EOC. In patients with grade 3 tumors or clear cell histology, treatment can be individualized, weighing a slightly higher risk of recurrence with fertility goals. A multidisciplinary approach with oncology and reproductive endocrinology may be of utility to help these patients achieve their fertility goals.

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“…Las tasas similares de fertilización, implantación, embarazo, aborto y número de recién nacidos vivos producto de oocitos frescos vs. vitrificados sugiere no sólo la integridad morfológica, sino también la funcional. 36,37 La vitrificación ha mostrado tasas de embarazos superiores a la técnica de enfriamiento lento así como mayor supervivencia de oocitos congelados, por lo que actualmente se considera la técnica de elección. 18,38 Un metaanálisis que incluyó 14 estudios controlados, aleatorizados que compararon ambas técnicas sugiere que la vitrificación puede ser más efectiva causando menos daño a folículos primordiales así www.medigraphic.org.mx como menor tasa de rupturas en el ADN y mejor preservación de células estromales.…”

Section: Criopreservación De Oocitosunclassified

Técnicas de preservación de la fertilidad femenina y experiencia en la Clínica de Fertilización Asistida en el Centro Médico ABC

Martínez¹,

Camacho²,

Cófrades³

et al. 2020

Anales Médicos De La Asociación Médica Del Centro Médico ABC

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A comparison of live birth rates and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos

Abstract: In our study, live birth rates and perinatal outcomes were not significantly different in patients after oocyte and embryo cryopreservation.

Cited by 29 publications

References 31 publications

Elective oocyte cryopreservation for age-related fertility decline

Elective oocyte cryopreservation for age-related fertility decline

Fertility‐sparing treatment for early‐stage epithelial ovarian cancer: Contemporary oncologic, reproductive and endocrinologic perspectives

Técnicas de preservación de la fertilidad femenina y experiencia en la Clínica de Fertilización Asistida en el Centro Médico ABC

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