A Comparison of Lithium and T&lt;char aid="99818416" id="sub"&gt;3&lt;/char&gt; Augmentation Following Two Failed Medication Treatments for Depression: A STAR*D Report

Nierenberg, Andrew A.

doi:10.1176/appi.ajp.163.9.1519

Cited by 81 publications

(15 citation statements)

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“…Observations that (subclinical) hypothyroidism is related to mood changes and depression [28,29,30,31], that the treatment response of depression and risk of recurrence are related to thyroid hormone status at the outset of treatment [31,32,33,34] and that pharmacological treatment of depression may be augmented by T3 supplementation [35,36,37,38] all support the view that subnormal thyroid hormone status influences mood. Depression is a common comorbid state in EDs [39, 40] and depressive symptoms are often partly relieved upon nutritional rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Triiodothyronine Is an Indicator of Nutritional Status in Adolescent Girls with Eating Disorders

Swenne

Stridsberg²,

Thurfjell

et al. 2009

Horm Res Paediatr

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Aim: Circulating thyroid hormone concentrations are influenced by nonthyroidal disease and changes in nutritional status. We studied thyroid hormones as possible indicators of nutrition in adolescent girls with eating disorders. Method: Blood samples for analyses of thyroid hormones were obtained at 360 assessments of 298 patients and biweekly during 42 treatment periods in 36 patients. Results: At assessment, when most of the girls were on a weight losing course, serum triiodothyronine (T3) concentrations were low. Great weight loss and rapid rate of weight loss were the most important predictors of low T3 concentrations. Serum free thyroxine concentrations were in the lower normal range. In premenarcheal girls, weight loss was the most important predictor of free thyroxine but this relationship was weaker in postmenarcheal girls. Serum TSH concentrations were within the normal range and only weakly related to weight changes. During treatment, T3 increased in parallel with weight but was also influenced by the short-term weight trend. Conclusion: Serum T3 concentration is an indicator of nutritional status in adolescent girls with eating disorders. It is sensitive to short-term weight changes and could be used to monitor progress throughout nutritional rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Triiodothyronine Is an Indicator of Nutritional Status in Adolescent Girls with Eating Disorders

Swenne

Stridsberg²,

Thurfjell

et al. 2009

Horm Res Paediatr

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“…In conformity with this goal of enrolling more representative MDD patients, the NIMH-funded STAR*D study [32,33,34,35,36,37,38]:…”

Section: Real-world Effectiveness Of Antidepressantsmentioning

confidence: 99%

“…In the step-1 to step-4 studies, the QIDS-SR was the secondary measure for identifying remissions and sole measure for identifying responders while the HRSD was the primary measure for identifying remitted patients [32,33,34,35,36,37]. …”

Section: Change In One Of the Outcome Measuresmentioning

confidence: 99%

Efficacy and Effectiveness of Antidepressants: Current Status of Research

Pigott¹,

Leventhal

Alter³

et al. 2010

Psychother Psychosom

295

214

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Background: This paper examines the current status of research on the efficacy and effectiveness of antidepressants. Methods: This paper reviews four meta-analyses of efficacy trials submitted to America’s Food and Drug Administration (FDA) and analyzes STAR*D (Sequenced Treatment Alternatives to Relieve Depression), the largest antidepressant effectiveness trial ever conducted. Results: Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious compared to placebos and document profound publication bias that inflates their apparent efficacy. These meta-analyses also document a second form of bias in which researchers fail to report the negative results for the pre-specified primary outcome measure submitted to the FDA, while highlighting in published studies positive results from a secondary or even a new measure as though it was their primary measure of interest. The STAR*D analysis found that the effectiveness of antidepressant therapies was probably even lower than the modest one reported by the study authors with an apparent progressively increasing dropout rate across each study phase. Conclusions: The reviewed findings argue for a reappraisal of the current recommended standard of care of depression.

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“…Recent data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study demonstrate that algorithms using augmentation or switching medications to treat resistant depression have limited efficacy (3,4). This study assessed predictors of sustained major depression among adults receiving care in community outpatient settings.…”

mentioning

confidence: 99%

Predictors of Major Depression Six Months After Admission for Outpatient Treatment

Weinberger

Sirey²,

Bruce³

et al. 2008

Psychiatric Services

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Objective This study examined the rate and predictors of major depression six months after outpatient mental health admission. Methods Assessments were conducted at admission and three and six months later among 166 participants. Antidepressant treatment adequacy and depression outcomes were assessed at follow-ups. Results Predictors of major depression at six months included nonremission status at three months (odds ratio [OR]=3.56, p=.003), inadequacy of early pharmacotherapy (OR=2.73, p=.009), worse physical functioning measured by the 36-Item Short-Form Health Survey (OR=.975, p<.001), and being unmarried (OR=2.54, p=.031). Conclusions The findings support the effects of baseline physical disability, marital status, early treatment adequacy, and early remission on the course of major depression. The identification of individuals who do not receive intensive pharmacotherapy or who have not recovered by three months may provide opportunities for interventions to optimize six-month outcomes and to prevent the development of a persistent depression.

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A Comparison of Lithium and T<char aid="99818416" id="sub">3</char> Augmentation Following Two Failed Medication Treatments for Depression: A STAR*D Report

Cited by 81 publications

References 0 publications

Triiodothyronine Is an Indicator of Nutritional Status in Adolescent Girls with Eating Disorders

Triiodothyronine Is an Indicator of Nutritional Status in Adolescent Girls with Eating Disorders

Efficacy and Effectiveness of Antidepressants: Current Status of Research

Predictors of Major Depression Six Months After Admission for Outpatient Treatment

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