A comparison of left ventricular volume-pressure relations of excised perfused canine hearts in isovolumic contraction, arrest and fibrillation.

Maruyama, Yukio; Nunokawa, Tohru; Koiwa, Yoshiro; Isoyama, Shogen; Ikeda, Kazuhiro; Ino-Oka, Eiji; Takishima, Tamotsu

doi:10.1620/tjem.136.141

Cited by 2 publications

(1 citation statement)

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“…If so, the left ventricular end-ejection pressure-ejected volume relationship is considered to be essentially the same as the left ventricular pressure-volume relationship at end-ejection, which has been used for assessing the contractile state of the heart as an approximation of the endsystolic pressure-volume relationship (Kono et al 1984). However, this should be considered in light of the following limitation, i.e., in the present study, although left ventricular end-diastolic pressure was kept constant within +0.5 mmHg of the initial control value, a 1 mmHg change of left ventricular end-diastolic pressure corresponded to an approximately 2.5 ml change in left ventricular end-diastolic volume in comparable values of left ventricular end-diastolic pressure and heart weight used in the present study (Maruyama et al 1982b).…”

Section: Methodological Considerationsmentioning

confidence: 78%

Effects of coronary artery stenosis on left ventricular end-ejection pressure-ejected volume relationships in isolated perfused canine hearts.

Maruyama

Shimizu

Watanabe

et al. 1985

Tohoku J. Exp. Med.

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We investigated the behavior of the left ventricular end-ejection pressure-ejected volume relation with and without left circumflex coronary stenosis in isolated perfused canine hearts. To change ventricular afterload pressure, the peripheral resistance of the hydraulic model attached to the aortic root of the excised hearts was changed in a stepwise fashion to five different levels. The end-ejection pressure-ejected volume relationship was nearly linear in both preischemic and ischemic states. The slope changes following left circumflex coronary stenosis differed among the hearts used in the present study, and there was no significant difference in average slope (n =10) between the pre-ischemic and ischemic states (i,e., -7.4+1.0 and -8.4+1.2 mmHg/ml, respectively). Therefore, the slope of the relation was not useful in judging the presence of depressed ventricular function induced by coronary stenosis. In contrast, the ejected volume axis intercept decreased significantly from 16.5+1.1 ml to 13.6+1.1 ml (p<0.05) with regional ischemic.

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Section: Methodological Considerationsmentioning

confidence: 78%