A comparison of ketamine-midazolam combination and propofol-fentanyl combination on procedure comfort and recovery process in pediatric colonoscopy procedures

Saylan, Sedat; Akbulut, Ulaş Emre

doi:10.12669/pjms.37.2.2787

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…RSS varied more in group FP, while variations according to our results for group KP and group C were the same. Compared with a study using fentanyl-propofol and ketamine-midazolam sedation protocol in children, RSS was higher in group ketamine-midazolam,[ 18 ] on the basis of which we could conclude that combination of ketamine-propofol is better in relation to the already mentioned ones. In means of sedation-related complications, we observed that patients in Group KP were also less likely to suffer from complications such as desaturation, which was most common complication in Group FP.…”

Section: Discussioncontrasting

confidence: 56%

Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study

Kovačević¹,

Rizvanović²,

Adilović³

et al. 2022

Saudi J Anaesth

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Aim: The aim of the study was to compare the analgesic effects of ketamine over fentanyl combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety and satisfaction. Methods: This is a double-blinded prospective randomized controlled trial. Ninety patients were included and randomized to either fentanyl-propofol (Group FP, n : 30), ketamine-propofol (Group KP, n : 30) or propofol-control group (Group C, n : 30). Group FP patients received fentanyl and propofol, Group KP received ketamine and propofol and Group C, propofol. In all groups, incremental doses of propofol were used to maintain a Ramsay sedation score (RSS) of 5. Respiratory depression and hemodynamic parameters were monitored for the first minute and every 5 min during endoscopy. Fifteen minutes after the procedure, the degree of pain was assessed using a visual analog scale (VAS), the quality of recovery according to the Aldrete score (ARS), complications during and after the procedure and additional doses of propofol were recorded. Results: Mean arterial pressure (MAP) at 5 and 30 min ( p < 0.05), heart rate (HR) at 15, 25 and 30 min ( p < 0.05) and peripheral oxygen saturation (SpO 2 ) at 30 min ( p < 0.05) were statistically significant for Group FP. Desaturation (* p = 0.033), and weakness (* p = 0.004) was also significant for Group FP at 20, 25 and 30 min ( p < 0.05). Pain was lower assessed for the Group KP according to the VAS (** p = 0.025). Conclusion: In analgesia-based colonoscopy, ketamine provides appropriate analgesia and less incidence of complications compared to fentanyl.

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Section: Discussioncontrasting

confidence: 56%

Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study

Kovačević¹,

Rizvanović²,

Adilović³

et al. 2022

Saudi J Anaesth

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“…11 , 12 Therefore, timely interventions to promote recovery are particularly important. Ketamine has anti-inflammatory and neuroprotective proprieties, 13 , 14 with significant analgesic effects at low doses and narcotic effects at high doses. 15 Esketamine is twice as potent as racemic ketamine.…”

Section: Discussionmentioning

confidence: 99%

Effect of single intravenous injection of esketamine on quality of recovery during early period after modified radical mastectomy for breast cancer: A retrospective study

Fei,

Yan,

Yao

2023

Pak J Med Sci

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Objective: To assess the impact of a single esketamine intravenous (IV) injection on the quality of recovery during early period after modified radical mastectomy for breast cancer. Methods: This retrospective study included 80 patients who underwent modified radical mastectomy under general anesthesia in Huzhou Maternity & Child Health Care Hospital from March to October 2022. All patients were between 35 to 55 years, weighting between 45 and 70 kg and Grade-I or II according to the American Society of Anesthesiologists (ASA). Patients were grouped based on the type of pain management used. Patients (n=40) who were given 0.25 mg/kg esketamine single IV injection prior to completion of the surgery were assigned to Group-E, and patients (n=40) who were not treated with esketamine, comprised the control Group-C. Patients’ data, such as education years, operation time, blood loss, the 9-item Quality of Recovery (QoR-9) scores before the anesthesia induction (T0), one (T1) and two hours after the extubation (T2), the 40-item Quality of Recovery (QoR-40) scores one (D1) and two days after the surgery (D2), and the rate of adverse reactions were assessed in both groups. Results: Compared with T0, the QoR-9 scores at T1 and T2 were markedly lower in all patients. Compared to Group-C, the QoR-9 scores at T1 and T2 in Group-E were considerably increased (P<0.05). Similarly, the QoR-40 scores on D1 and D2 in Group-E were significantly higher compared to Group-C (P<O.05). Conclusion: Single intravenous injection of esketamine can improve the quality of the recovery of breast cancer patients during the early period after the modified radical mastectomy. doi: https://doi.org/10.12669/pjms.39.6.8057 How to cite this: Fei G, Yan W, Yao H. Effect of single intravenous injection of esketamine on quality of recovery during early period after modified radical mastectomy for breast cancer: a retrospective study. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.8057 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Pain during the colonoscopy occurs due the air distension maneuvers of the colon and traction of the mesocolon, which is why patients scheduled for lower digestive endoscopy request it to be performed under sedation or analgosedation [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Anesthesia Medication’s Impacts on Inflammatory and Neuroendocrine Immune Response in Patients Undergoing Digestive Endoscopy

Popa-Ion,

Boldeanu,

Gheonea

et al. 2024

Clinics and Practice

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The aim of this study was to explore the impact of anesthetic drugs currently used to perform lower digestive endoscopy on serum concentrations of inflammation markers and catecholamines. We selected 120 patients and divided them into three lots of 40 patients each: L1, in which no anesthetics were used; L2, in which propofol was used; and L3, in which propofol combined with fentanyl was used. All patients had serum concentrations of adrenaline/epinephrine (EPI), noradrenaline/norepinephrine (NE), tumor necrosis factor alpha (TNF-α), interleukin-4 (IL-4), IL-6, IL-8, and IL-10, taken at three time points: at the beginning of the endoscopic procedure (T0), 15 min after (T1), and 2 h after the end of the endoscopic procedure (T2). The results of the research showed changes in the levels of catecholamines and interleukins (ILs) at T0, with an increased response in L1 above the mean recorded in L2 and L3 (p < 0.001). At T1, increased values were recorded in all lots; values were significantly higher in L1. At T2, the values recorded in L3 were significantly lower than the values in L2 (student T, p < 0.001) and L1, in which the level of these markers continued to increase, reaching double values compared to T0 (student T, p < 0.001). In L2 at T1, the dose of propofol correlated much better with NE, EPI, and well-known cytokines. Our results show that propofol combined with fentanyl can significantly inhibit the activation of systemic immune and neuroendocrine response during painless lower digestive endoscopy.

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A comparison of ketamine-midazolam combination and propofol-fentanyl combination on procedure comfort and recovery process in pediatric colonoscopy procedures

Cited by 4 publications

References 24 publications

Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study

Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study

Effect of single intravenous injection of esketamine on quality of recovery during early period after modified radical mastectomy for breast cancer: A retrospective study

Anesthesia Medication’s Impacts on Inflammatory and Neuroendocrine Immune Response in Patients Undergoing Digestive Endoscopy

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