A Comparison of Intravenous Sedation With Two Doses of Dexmedetomidine: 0.2 µg/kg/hr Versus 0.4 µg/kg/hr

Kawaai, Hiroyoshi; Satoh, Jun; Watanabe, Masahiro; Kan, Keiichi; Ganzberg, Steven; Yamazaki, Satoru

doi:10.2344/0003-3006-57.3.96

Cited by 13 publications

(16 citation statements)

References 22 publications

(13 reference statements)

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“…Hemodynamic stability was maintained within group D, with similar findings to previous studies. 3,9,12,[14][15][16]20,29 Heart rate decreased significantly compared with propofol during the initial 10minute loading dose and steadily increased once the procedure was initiated. Patients in group P had a decrease in MAP and respiratory rate compared with group D; however, this was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Provides Fewer Respiratory Events Compared With Propofol and Fentanyl During Third Molar Surgery: A Randomized Clinical Trial

Nolan

Delgadillo

Youssef

et al. 2020

Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Provides Fewer Respiratory Events Compared With Propofol and Fentanyl During Third Molar Surgery: A Randomized Clinical Trial

Nolan

Delgadillo

Youssef

et al. 2020

Journal of Oral and Maxillofacial Surgery

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“…However, sedation may carry a risk of an upper airway obstruction or unconsciousness, when using sedative agents. [14] The accumulation of experiences of dexmedetomidine sedation in such patients is necessary for its safe use.…”

Section: Discussionmentioning

confidence: 99%

Sedation with Dexmedetomidine during Tracheostomy in Severe Tracheal Stenotic Patients

Jun

Kim

Lee

et al. 2013

Korean J Crit Care Med

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In patients with severely compromised airways, a tracheostomy is usually performed under local anesthesia. Dexmedetomidine can be a better choice of sedative for such patients because it causes minimal respiratory depression. We report two cases of patients with severe stenosis of the airways who underwent sedation with dexmedetomidine during tracheostomy under local anesthesia. In the first case, recurrent laryngeal cancer caused laryngeal stenosis, and the narrowest laryngeal width was less than 3 mm. In the second case, the tracheostomy opening site was narrowed to a diameter of 3.4 mm in a patient with a history of total laryngectomy. For both patients, sedation was induced by dexmedetomidine infusion and the tracheostomy was performed successfully under local anesthesia without any events. Dexmedetomidine seems to be an effective and safe sedative for tracheostomies in patients with critical airways. The management and implications of sedation with dexmedetomidine in the patients with severe stenotic airways are discussed.

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“…[89] A comparison of two different doses of dexmedetomidine (0.5 ug/kg and 1 ug/kg) to suppress hemodynamic changes to tracheal intubations showed that the higher dose was more effective when used as bolus. [90]…”

Section: Evidence Based Comparison With Other Drugsmentioning

confidence: 99%

Dexmedetomidine: An adjuvant making large inroads into clinical practice

Bajwa

Kulshrestha

2013

Ann Med Health Sci Res

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The introduction of newer more selective α−2 adrenergic agonist, dexmedetomidine has made a revolution in the field of anesthesia owing to its varied application. The aim of the current review is to highlight the various clinical and pharmacological aspects of dexmedetomidine in daily routine practice of anesthesiology and intensive care besides its potential role in other clinical specialties. This review of dexmedetomidine was carried out after searching the medical literature in Pubmed, Science direct, Scopus, Google scholar and various text books and journal articles using keywords anesthesia, dexmedetomidine, neurosurgery, pediatric surgery, regional dexmedetomidine, anesthesia, regional, neurosurgery, and pediatric surgery. Dexmedetomidine has made its application from a novel sedating agent in the intensive care unit to its use as an adjuvant in various regional anesthetic techniques because of its “cooperative sedation” without any respiratory depression. It has a favorable pharmacokinetic profile suitable to be used in the perioperative period to reduce the requirements of opioids and anesthetic drugs. There are few side-effects of dexmedetomidine, which should always be kept in mind before choosing the patients for its use. The various side-effects associated with dexmedetomidine include, but are not limited to hypotension, bradycardia, worsening of heart block, dry mouth, and nausea. However, large scale randomized controlled trials are still needed to establish various effects of dexmedetomidine and to clearly define its safety profile.

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A Comparison of Intravenous Sedation With Two Doses of Dexmedetomidine: 0.2 µg/kg/hr Versus 0.4 µg/kg/hr

Cited by 13 publications

References 22 publications

Dexmedetomidine Provides Fewer Respiratory Events Compared With Propofol and Fentanyl During Third Molar Surgery: A Randomized Clinical Trial

Dexmedetomidine Provides Fewer Respiratory Events Compared With Propofol and Fentanyl During Third Molar Surgery: A Randomized Clinical Trial

Sedation with Dexmedetomidine during Tracheostomy in Severe Tracheal Stenotic Patients

Dexmedetomidine: An adjuvant making large inroads into clinical practice

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