A comparison of intravascular source designs based on the beta particle emitter 114mIn/114In

Schaart, Dennis R.; Marijnissen, Johannes P. A.

doi:10.1016/s1522-1865(02)00147-6

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…7, the radial dose function of the

^{90} Y

glass seed is compared to those of the several beta‐emitter seeds. ( 7 , 22 , 23 , 28 , 29 ) As observed in figure, the radial dose function of this seed is approximately similar to those of the

^{90} Sr false/^{90} normalY

, and

^{142} Pr

seeds. Also, the decrease in radial dose function for that is slower than to those of the

^{153} Sm,^{32} P

, and

^{114} In

sources.…”

Section: Resultssupporting

confidence: 68%

Monte Carlo characterization of biocompatible beta‐emitting glass seed incorporated with the radionuclide as a SPECT marker for brachytherapy applications

Hadadi

Sadeghi

Sardari

et al. 2013

J Applied Clin Med Phys

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A glass seed consisting of the β−‐emitting radionuclide 90Y incorporated with radionuclide 153Sm as SPECT marker is proposed for potential application in brachytherapy in order to reduce the undesirable dose to healthy adjacent organs. The aim of this work is to determine the dosimetric characteristics, as suggested in the AAPM TG‐60/TG‐149 reports, for this seed using Monte Carlo simulation. Monte Carlo codes MCNP5, EGSnrc, and FLUKA were used to calculate the absorbed dose distribution around the seed. Dosimetric parameters, such as reference absorbed dose rate, radial dose function, and one‐dimensional (1D) and two‐dimensional (2D) anisotropy functions, were obtained. The computational results from these three codes are in agreement within 5.4% difference on average. The absorbed dose rate at the reference point was estimated to be 5.01 cGy normalh−1 μCi−1 and self absorption of YAS glass seed amounted to 30.51%. The results showed that, with thermal neutron bombardment of 5 hours in a typical flux, sufficient activity for applications in brachytherapy may be achieved. With a 5 mCi initial activity, the total dose of a YAS glass seed was estimated to be 1.38 Gy at 1.0 cm from the seed center. Comparing with gamma emitting seeds, the 90Y seed could reduce undesirable doses to adjacent organs, because of the rapid dose falloff of beta ray. Because of the high R90 value of 5.5 mm, fewer number of 90Y seeds will be required for an interstitial brachytherapy treatment using permanent implant, in comparison with other beta‐emitting seeds. The results would be helpful in the development of the radioactive implants using 90Y glass seeds for the brachytherapy treatment.PACS numbers: 87.53.Jw, 87.56.bg

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“…7, the radial dose function of the

^{90} Y

glass seed is compared to those of the several beta‐emitter seeds. ( 7 , 22 , 23 , 28 , 29 ) As observed in figure, the radial dose function of this seed is approximately similar to those of the

^{90} Sr false/^{90} normalY

, and

^{142} Pr

seeds. Also, the decrease in radial dose function for that is slower than to those of the

^{153} Sm,^{32} P

, and

^{114} In

sources.…”

Section: Resultssupporting

confidence: 68%

Monte Carlo characterization of biocompatible beta‐emitting glass seed incorporated with the radionuclide as a SPECT marker for brachytherapy applications

Hadadi

Sadeghi

Sardari

et al. 2013

J Applied Clin Med Phys

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“…To avoid these boundary-crossing artefacts, Schaart et al developed and validated an electron track length estimator of absorbed dose that can be used in combination with non-interrupting, so-called segment boundaries (Briesmeister 2000) to define the scoring geometry. This method has been used successfully for the calculation of the dose distributions for several therapeutic beta sources (Schaart et al 2002b, Schaart and Marijnissen 2002c, Schaart 2002 and has also been used in the present calculations.…”

Section: Mcnp4c Simulationsmentioning

confidence: 99%

“…In figure 3 the GATE 6.0 results are also compared to the kernels calculated with MCNP4C (see section 2.3). The MCNP4C results were obtained using ITS energy indexing and using the electron track length estimator of absorbed dose that was introduced by Schaart et al (2002a) and that has been carefully validated for electron dose calculations (Schaart et al 2002b, Schaart and Marijnissen 2002c, Schaart 2002. The agreement between GATE 6.0 and MCNP4C is less good than that between GATE 6.0 and EGSnrc.…”

Section: Comparison Of Gate 60 Electron Dose Point Kernels With Egsnr...mentioning

confidence: 99%

Comparison of GATE/GEANT4 with EGSnrc and MCNP for electron dose calculations at energies between 15 keV and 20 MeV

et al. 2011

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The GATE Monte Carlo simulation platform based on the GEANT4 toolkit has come into widespread use for simulating positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging devices. Here, we explore its use for calculating electron dose distributions in water. Mono-energetic electron dose point kernels and pencil beam kernels in water are calculated for different energies between 15 keV and 20 MeV by means of GATE 6.0, which makes use of the GEANT4 version 9.2 Standard Electromagnetic Physics Package. The results are compared to the well-validated codes EGSnrc and MCNP4C. It is shown that recent improvements made to the GEANT4/GATE software result in significantly better agreement with the other codes. We furthermore illustrate several issues of general interest to GATE and GEANT4 users who wish to perform accurate simulations involving electrons. Provided that the electron step size is sufficiently restricted, GATE 6.0 and EGSnrc dose point kernels are shown to agree to within less than 3% of the maximum dose between 50 keV and 4 MeV, while pencil beam kernels are found to agree to within less than 4% of the maximum dose between 15 keV and 20 MeV.

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“…Brachytherapy is one type of internal radiation therapy used for cancer treatment, in which sealed radiation sources (e.g., needles, seeds, or capsules) are placed in short-distance from the target volume or directly into the area of the patient body that requires treatment [1,2]. Brachytherapy treatments can be classified according to different criteria including, implant methods, implant duration, loading systems, and radiation dose rate delivered by β and γ emission [3,4].…”

Section: Purposementioning

confidence: 99%

“…Monte Carlo methods are involved in many applications in nuclear medicine, such as nuclear medicine imaging (SPECT) [13] and radiation therapy (brachytherapy) [1,2,3,4,5]. The MC technique for brachytherapy applications is used as a tool for evaluation and validation of dose distribution in phantoms and patient anatomy as well as some useful dosimetric parameters such as dose distribution function, radial dose variation, and dose calculation at the reference point, according to the standard protocols by using random numbers [14].…”

Section: Purposementioning

confidence: 99%

Monte Carlo dosimetry for a new 32P brachytherapy source using FLUKA code

Rajabi¹,

Taherparvar²

2019

jcb

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PurposeDosimetric characterization of a new 32P brachytherapy source was studied and the validity of the FLUKA code to reproduce the dosimetric parameters in a water phantom was evaluated. In addition, dose rate distributions around the 32P source sheathed by a catheter and unsheathed source were investigated in different tissue phantoms.Material and methodsThe new 32P source was modeled using FLUKA Monte Carlo code. According to the AAPM TG-60 recommendations, reference of absorbed dose rate, radial dose function, anisotropy function, and an away-along table for quality assurance purposes inside water phantom were calculated. Moreover, the results of the radial dose function and dose rate were obtained for the sheathed source and unsheathed sources at radial distances in different tissue phantoms: liver, fat tissue, 9-component soft tissue, and 4-component soft tissue.ResultsThe calculated dosimetric parameters of the new 32P source by FLUKA code in water phantom agreed well with that of the GEANT4 calculation. The 2D away-along dose results were similar to the GEANT4 simulation for distances less than 0.25 cm, small differences were apparent at long distances from the source. Dose rate evaluation for the sheathed source shows that the presence of a catheter increases the dose values up to 2.11% in comparison with the unsheathed source in water phantom. Our results show that the radial dose function calculated in water, as generalized by AAPM TG-60, differed in tissue, especially at large distances from the source.ConclusionsThis work fully characterizes dosimetric parameters of the sheathed and unsheathed new 32P brachytherapy sources in water and different tissue phantoms by using FLUKA code. The results demonstrate that the dose distribution in water differed from the calculated ones in tissue phantoms due to the densities and atomic composition for tissues that are not taken account by the TG-60 formalism.

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A comparison of intravascular source designs based on the beta particle emitter 114mIn/114In

Cited by 8 publications

References 18 publications

Monte Carlo characterization of biocompatible beta‐emitting glass seed incorporated with the radionuclide as a SPECT marker for brachytherapy applications

Monte Carlo characterization of biocompatible beta‐emitting glass seed incorporated with the radionuclide as a SPECT marker for brachytherapy applications

Comparison of GATE/GEANT4 with EGSnrc and MCNP for electron dose calculations at energies between 15 keV and 20 MeV

Monte Carlo dosimetry for a new 32P brachytherapy source using FLUKA code

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