A comparison of insulin suppression tests performed with somatostatin and octreotide with particular reference to tolerability

Hwu, Chii‐Min; Kwok, Ching Fai; Chiang, Shu Chiung; Wang, Pi-Ying; Hsiao, Liang‐Tsai; Lee, Sheng-Hung; Lin, Shu-Hsia; Ho, ­Low‐Tone

doi:10.1016/s0168-8227(00)00238-2

Cited by 10 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1983). Complications associated with somatostatin infusion such as gastrointestinal discomfort, diarrhoea or fainting observed in human subjects (Hwu et al. 2001) were not detected in this study.…”

Section: Discussioncontrasting

confidence: 48%

See 1 more Smart Citation

Measurement of C‐peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses

Tóth

Frank

Martı́n-Jiménez

et al. 2010

Equine Veterinary Journal

View full text Add to dashboard Cite

SummaryReasons for performing study: Hyperinsulinaemia is detected in horses with insulin resistance (IR) and has previously been attributed to increased pancreatic insulin secretion.Connecting peptide (C-peptide) can be measured to assess pancreatic function because it is secreted in equimolar amounts with insulin and does not undergo hepatic clearance. Median C-peptide and insulin concentrations were 1.5-and 9.5-fold higher, respectively in horses with IR, compared with healthy horses. Conclusions: Endogenous C-peptide secretion decreases in response to somatostatin and increases after dextrose infusion. Results suggest that relative insulin clearance decreases as pancreatic secretion increases in response to dextrose infusion. Hyperinsulinaemia in insulin resistant horses may be associated with both increased insulin secretion and decreased insulin clearance. Potential relevance: Both C-peptide and insulin concentrations should be measured to assess pancreatic secretion and insulin clearance in horses.

show abstract

Section: Discussioncontrasting

confidence: 48%

“…These findings are consistent with previous observations in man, as i.v. administration of somatostatin or its analogue octreotide, resulted in only partial suppression of C‐peptide release to 48% and 27% of baseline concentrations, respectively (Hwu et al. 2001).…”

Section: Discussionmentioning

confidence: 99%

Measurement of C‐peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses

Tóth

Frank

Martı́n-Jiménez

et al. 2010

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…First, during the R‐L and Ex‐L trials it was assumed that insulin action was absent. However, consistent with previous observations in man (Hwu et al . 2001) and horses (Tóth et al .…”

Section: Discussionsupporting

confidence: 94%

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Geor¹,

Stewart-Hunt

McCutcheon

2010

Equine Veterinary Journal

View full text Add to dashboard Cite

“…The IST was performed at 8 am after a 12-h overnight fast. 18 All subjects were infused with regular insulin (Humulin-R, Lilly, IN, USA; 25 mU/min m 2 ) and glucose (TAIYU, Shin-Tzu, Taiwan; 240 mg/min m 2 ) simultaneously for 180 min with infusion pumps (Harvard Apparatus, Boston, MA, USA). In addition, somatostatin (5 g/min) (Stilamin, Serono, Aubonne, Switzerland) was infused intravenously over the same period of time.…”

Section: Metabolic Assessmentsmentioning

confidence: 99%

Exacerbation of insulin resistance and postprandial triglyceride response in newly diagnosed hypertensive patients with hypertriglyceridaemia

et al. 2002

View full text Add to dashboard Cite

The purpose of the study is to examine the differences in insulin resistance and postprandial triglyceride (TG) response between hypertensive patients with or without hypertriglyceridaemia. The study is a comparative cohort study with matching. Thirty-one newly diagnosed hypertensive patients without any medication were recruited from a health survey. The participants were further divided into two groups: those with fasting TG Ͻ2.26 mmol/L, and those with TG between 2.26 and 5.65 mmol/L. Both groups were matched in age, sex, body mass index and waist circumference. Each patient received a 75-g oral glucose tolerance test, an insulin suppression test, and a 1000 kcal high fat mixed meal test. The hypertriglyceridaemic hypertensive patients had significantly higher fasting insulin, 2-h plasma glucose, 2-h insulin, and steady-state plasma glucose (SSPG) (13.16 ± 1.87 vs 9.76 ± 3.18 mmol/L). They also had a greater postprandial TG response to the challenge

show abstract

A comparison of insulin suppression tests performed with somatostatin and octreotide with particular reference to tolerability

Cited by 10 publications

References 23 publications

Measurement of C‐peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses

Measurement of C‐peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Exacerbation of insulin resistance and postprandial triglyceride response in newly diagnosed hypertensive patients with hypertriglyceridaemia

Contact Info

Product

Resources

About