2012
DOI: 10.1245/s10434-012-2478-0
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A Comparison of Indocyanine Green Fluorescence Imaging Plus Blue Dye and Blue Dye Alone for Sentinel Node Navigation Surgery in Breast Cancer Patients

Abstract: ICG-FI is a useful method and is especially recommended in cases where no radiotracers are available.

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Cited by 71 publications
(35 citation statements)
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“…With the development of systems allowing for perioperative detection of fluorescence, additional studies used primarily this phenomenon for visualizing lymph vessels and nodes. The first studies from 2008 demonstrating the clinical usability of ICG for visualizing the lymphatic system in the breast [916] were followed by studies evaluating primarily the combined use of the dye and ICG [1721]. In work to optimize the methodology, no clear advantage was demonstrated from applying ICG conjugated with albumin in comparison with application of just ICG [22].…”
Section: Introductionmentioning
confidence: 99%
“…With the development of systems allowing for perioperative detection of fluorescence, additional studies used primarily this phenomenon for visualizing lymph vessels and nodes. The first studies from 2008 demonstrating the clinical usability of ICG for visualizing the lymphatic system in the breast [916] were followed by studies evaluating primarily the combined use of the dye and ICG [1721]. In work to optimize the methodology, no clear advantage was demonstrated from applying ICG conjugated with albumin in comparison with application of just ICG [22].…”
Section: Introductionmentioning
confidence: 99%
“…Yet, there is no clear evidence regarding NACinduced changes in the lymphatic pathways to the SLNs (sentinel lymphatic pathways). The indocyanine green (ICG)-fluorescence method is useful for SLNB because it offers a high SLN identification rate and good visualizations of lymphatic pathways [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Yet, there is no clear evidence regarding NACinduced changes in the lymphatic pathways to the SLNs (sentinel lymphatic pathways). The indocyanine green (ICG)-fluorescence method is useful for SLNB because it offers a high SLN identification rate and good visualizations of lymphatic pathways [4,5].In this study, we compared the features of sentinel lymphatic pathways before and after NAC by using the ICG-fluorescence method of SLNB (ICG-SLNB). We analyzed the effect of chemotherapy on sentinel lymphatic pathways and the SLN location.…”
mentioning
confidence: 99%
“…[12][13][14] Other clinical applications of ICG are in assessment of cardiovascular and liver functions. 15,16 ICG has also been investigated in patients with breast, gastric, and skin cancer undergoing sentinel lymph node mapping, [17][18][19][20][21][22][23] and evaluation of lymphedema. 24,25 Despite its proven efficacy in these applications, the utility of ICG for broader clinical usage has been limited due to its nonspecific binding to albumin and high-density lipoproteins in plasma.…”
Section: Introductionmentioning
confidence: 99%