A Comparison of Indocyanine Green Fluorescence Imaging Plus Blue Dye and Blue Dye Alone for Sentinel Node Navigation Surgery in Breast Cancer Patients

Hirano, Akira; Kamimura, Mari; Ogura, Kaoru; Kim, Naomi; Hattori, Akihiko; Setoguchi, Yumika; Okubo, Fumie; Inoue, Hiroaki; Miyamoto, Reiko; Koyama, Jun; Fujibayashi, Mariko; Shimizu, Tadao

doi:10.1245/s10434-012-2478-0

Cited by 71 publications

(35 citation statements)

References 21 publications

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“…With the development of systems allowing for perioperative detection of fluorescence, additional studies used primarily this phenomenon for visualizing lymph vessels and nodes. The first studies from 2008 demonstrating the clinical usability of ICG for visualizing the lymphatic system in the breast [9–16] were followed by studies evaluating primarily the combined use of the dye and ICG [17–21]. In work to optimize the methodology, no clear advantage was demonstrated from applying ICG conjugated with albumin in comparison with application of just ICG [22].…”

Section: Introductionmentioning

confidence: 99%

Use of indocyanine green and the HyperEye system for detecting sentinel lymph nodes in breast cancer within a population of European patients: a pilot study

Coufal

Fait

2016

World J Surg Onc

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BackgroundCertain studies suggest that using indocyanine green (ICG) could be comparable with using radioisotopes (RI) in detecting sentinel lymph nodes (SLNs) in breast cancer. A number of these studies were performed in Asia. The objective of our pilot study was to evaluate within a European population of breast cancer patients the detection rate of SLNs using ICG and the HyperEye system and the concordance in SLNs detected using this method and the standard method involving RI and a gamma probe.MethodsTen female patients with early-stage breast cancer (Czech Republic) indicated for partial mastectomy and SLN biopsy were subjected to standard application of RI. Before surgery, ICG was administered periareolarly in the amount of 1 ml of 0.5% solution. Sentinel lymph nodes were first detected perioperatively exclusively using ICG fluorescence and the HyperEye device (Mizuho, Japan). Only after removal of all SLNs found in this way was the standard hand-held gamma probe used to detect RI, and any potential additional SLNs not found with ICG were then extirpated.ResultsIn all 10 cases, at least one SLN was successfully detected using ICG. Nevertheless, in five patients, 1–4 additional SLNs were found using the gamma probe. Complete concordance in detecting SLNs therefore occurred in only one half of the cases. Metastases in SLNs were found in a total of two cases. Had we used only ICG for detection, one of these two cases would have been incorrectly evaluated as N0 (ICG false negativity).ConclusionsThe study did not confirm the hypothesis that the use of ICG with the HyperEye system can currently be considered a method fully comparable with using RI and a gamma probe in a population of European patients. Although the detection rate is high, a significantly lower number of SLNs were detected using ICG than using RI (p = 0.03). Thus, there would be a higher probability for false negatives to occur in using SLN biopsy. This is caused mainly by the limited permeability of tissues to fluorescent radiation and the difficulty therefore of detecting nodes located deeper beneath the body’s surface.

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Section: Introductionmentioning

confidence: 99%

Use of indocyanine green and the HyperEye system for detecting sentinel lymph nodes in breast cancer within a population of European patients: a pilot study

Coufal

Fait

2016

World J Surg Onc

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Section: Introductionmentioning

confidence: 99%

“…Yet, there is no clear evidence regarding NACinduced changes in the lymphatic pathways to the SLNs (sentinel lymphatic pathways). The indocyanine green (ICG)-fluorescence method is useful for SLNB because it offers a high SLN identification rate and good visualizations of lymphatic pathways [4,5].In this study, we compared the features of sentinel lymphatic pathways before and after NAC by using the ICG-fluorescence method of SLNB (ICG-SLNB). We analyzed the effect of chemotherapy on sentinel lymphatic pathways and the SLN location.…”

mentioning

confidence: 99%

Assessing the effects of neoadjuvant chemotherapy on lymphatic pathways to sentinel lymph nodes in cases of breast cancer: Usefulness of the indocyanine green-fluorescence method

et al. 2015

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“…[12][13][14] Other clinical applications of ICG are in assessment of cardiovascular and liver functions. 15,16 ICG has also been investigated in patients with breast, gastric, and skin cancer undergoing sentinel lymph node mapping, [17][18][19][20][21][22][23] and evaluation of lymphedema. 24,25 Despite its proven efficacy in these applications, the utility of ICG for broader clinical usage has been limited due to its nonspecific binding to albumin and high-density lipoproteins in plasma.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

Bahmani¹,

Lytle²,

Walker³

et al. 2013

IJN

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Near-infrared nanoconstructs present a potentially effective platform for site-specific and deep tissue optical imaging and phototherapy. We have engineered a polymeric nanocapsule composed of polyallylamine hydrochloride (PAH) chains cross-linked with sodium phosphate and doped with indocyanine green (ICG) toward such endeavors. The ICG-doped nanocapsules were coated covalently with polyethylene glycol (5000 daltons) through reductive amination. We administrated the constructs by tail vein injection to healthy mice. To characterize the biodistribution of the constructs, we performed in vivo quantitative fluorescence imaging and subsequently analyzed the various extracted organs. Our results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time of ICG and delay its hepatic accumulation. Increased bioavailability of ICG, due to encapsulation, offers the potential of extending the clinical applications of ICG, which are currently limited due to rapid elimination of ICG from the vasculature. Our results also indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study.

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A Comparison of Indocyanine Green Fluorescence Imaging Plus Blue Dye and Blue Dye Alone for Sentinel Node Navigation Surgery in Breast Cancer Patients

Abstract: ICG-FI is a useful method and is especially recommended in cases where no radiotracers are available.

Cited by 71 publications

References 21 publications

Use of indocyanine green and the HyperEye system for detecting sentinel lymph nodes in breast cancer within a population of European patients: a pilot study

Use of indocyanine green and the HyperEye system for detecting sentinel lymph nodes in breast cancer within a population of European patients: a pilot study

Assessing the effects of neoadjuvant chemotherapy on lymphatic pathways to sentinel lymph nodes in cases of breast cancer: Usefulness of the indocyanine green-fluorescence method

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

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