A Comparison of in Vivo and in Vitro Tests for Antineoplastic Activity of Eight Compounds

Eichorn, P. A.; Huffman, K. V.; Oleson, J. J.; Halliday, Sybella L.; Williams, Jon L.

doi:10.1111/j.1749-6632.1954.tb45899.x

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…In 1954 E ichorn et al [36] and in 1961 Di Paolo and Dow d [37] obtained encouraging results with in vitro testing of anti-neoplastic activity of chemotherapeutic agents. RoyCamille et al in 1972 [38] reported the use of ''antimitograms" in osteogenic sarcomas to study the optimum effect of anti-neoplastic agents against short term primary tumor cell cultures removed from patients before chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Pathologic Aspects of Chemotherapy Response in the Treatment of Osteogenic Sarcoma. An Analysis of Two Cases

Marroum¹,

Huvos²,

Rosen³

1977

Oncology

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Two patients with osteogenic sarcoma of the proximal tibia were treated pre-operatively with intensive chemotherapy with high dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) and adriamycin (ADR). One patient died before surgery. The other underwent en bloc resection of the primary tumor with prosthetic replacement of the involved tibia, followed by adjuvant chemotherapy consisting of HDMTX with CFR and ADR, but died of metastases. Complete control of the primary or metastatic tumor was not achieved. It is emphasised that intensive multiple drug chemotherapy should be administered with extreme caution. The histologic findings are carefully analysed in relation to objective tumor response and toxic chemotherapy effects.

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Section: Discussionmentioning

confidence: 99%

Pathologic Aspects of Chemotherapy Response in the Treatment of Osteogenic Sarcoma. An Analysis of Two Cases

Marroum¹,

Huvos²,

Rosen³

1977

Oncology

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“…Another popular concept of model related to cancer is that of "in vitro" or "in glass" experiments. These models refer to investigations performed with cells, organisms or parts of organisms in Petri dishes or similar equipment and have been used for a long time in cancer-related experiments, such as cell growth [58] and the screening of antitumour substances [59]. These experiments imply artificial conditions and a significant simplification of the microenvironment of a tumour.…”

Section: Different Concepts Of Model 21 Model: "An Animal or Plant To...mentioning

confidence: 99%

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?

Reyes-Aldasoro

2023

Cancers

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The Oxford English Dictionary includes 17 definitions for the word “model” as a noun and another 11 as a verb. Therefore, context is necessary to understand the meaning of the word model. For instance, “model railways” refer to replicas of railways and trains at a smaller scale and a “model student” refers to an exemplary individual. In some cases, a specific context, like cancer research, may not be sufficient to provide one specific meaning for model. Even if the context is narrowed, specifically, to research related to the tumour microenvironment, “model” can be understood in a wide variety of ways, from an animal model to a mathematical expression. This paper presents a review of different “models” of the tumour microenvironment, as grouped by different definitions of the word into four categories: model organisms, in vitro models, mathematical models and computational models. Then, the frequencies of different meanings of the word “model” related to the tumour microenvironment are measured from numbers of entries in the MEDLINE database of the United States National Library of Medicine at the National Institutes of Health. The frequencies of the main components of the microenvironment and the organ-related cancers modelled are also assessed quantitatively with specific keywords. Whilst animal models, particularly xenografts and mouse models, are the most commonly used “models”, the number of these entries has been slowly decreasing. Mathematical models, as well as prognostic and risk models, follow in frequency, and these have been growing in use.

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Growth of Gynecologic Neoplasms in Tissue Culture and as Heterografts

Welander¹,

LewisJr.²

1983

Gynecologic Oncology

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A Comparison of in Vivo and in Vitro Tests for Antineoplastic Activity of Eight Compounds

Cited by 6 publications

References 6 publications

Pathologic Aspects of Chemotherapy Response in the Treatment of Osteogenic Sarcoma. An Analysis of Two Cases

Pathologic Aspects of Chemotherapy Response in the Treatment of Osteogenic Sarcoma. An Analysis of Two Cases

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?

Growth of Gynecologic Neoplasms in Tissue Culture and as Heterografts

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