A Comparison of Image-Guided Targeted Prostate Biopsy Outcomes by PI-RADS® Score and Ethnicity in a Diverse, Multiethnic Population

Hines, Laena; Zhu, Denzel; DeMasi, Matt; Babar, Mustufa; Chernyak, Victoria; Kovac, Evan; Aboumohamed, Ahmed; Sankin, Alex; Agalliu, Ilir; Watts, Kara

doi:10.1097/ju.0000000000001810

Cited by 5 publications

(3 citation statements)

References 16 publications

(27 reference statements)

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“…Although the majority of patients had an mpMRI read using version 2.0 (92%), Hispanic patients had a higher proportion of mpMRIs read using version 2.1 and still had a significantly lower sensitivity. Our finding of a trend for lower sensitivity of PIRADS ≥ 3 largely using version 2.0 in Hispanic men is particularly important as a report by Hines et al using PIRADS version 2.0 demonstrated that mpMRI has similar odds of detecting GG2-5 PCa in Hispanic men (OR 1.90, 95% CI 0.69–5.24, p = 0.22) compared to White men (OR 1.0) [ 13 ]. Larger sample sizes of Hispanic men would be needed to validate the lower sensitivity of mpMRI in Hispanic men.…”

Section: Discussionmentioning

confidence: 56%

“…All results were reported by racial/ethnic groups as White, Black and Hispanic; Hispanic White and Hispanic Black participants are included among Hispanics which is consistent with the US Census, NIH, and other PIRADS studies reporting of race and ethnicity [ 13 ]. Methods for self-reporting were consistent throughout the entire study.…”

Section: Methodsmentioning

confidence: 76%

“…One of the strengths of our study is our focus on biopsy-naïve populations and the inclusion of Hispanics. Other studies comparing PIRADS performance and outcomes in diverse populations include patients on Active Surveillance or patients with previous negative biopsies [ 13 , 24 , 25 ]. Our cohort is exclusively biopsy-naïve which lends well to helping urologists make clinical decisions on biopsy-naïve patients that present to clinic.…”

Section: Discussionmentioning

confidence: 99%

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Assessing the accuracy of multiparametric MRI to predict clinically significant prostate cancer in biopsy naïve men across racial/ethnic groups

et al. 2022

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Introduction The Prostate Imaging Reporting and Data System (PIRADS) has shown promise in improving the detection of Gleason grade group (GG) 2–5 prostate cancer (PCa) and reducing the detection of indolent GG1 PCa. However, data on the performance of PIRADS in Black and Hispanic men is sparse. We evaluated the accuracy of PIRADS scores in detecting GG2-5 PCa in White, Black, and Hispanic men. Methods We performed a multicenter retrospective review of biopsy-naïve Black (n = 108), White (n = 108), and Hispanic (n = 64) men who underwent prostate biopsy (PB) following multiparametric MRI. Sensitivity and specificity of PIRADS for GG2-5 PCa were calculated. Race-stratified binary logistic regression models for GG2-5 PCa using standard clinical variables and PIRADS were used to calculate area under the receiver operating characteristics curves (AUC). Results Rates of GG2-5 PCa were statistically similar between Blacks, Whites, and Hispanics (52.8% vs 42.6% vs 37.5% respectively, p = 0.12). Sensitivity was lower in Hispanic men compared to White men (87.5% vs 97.8% respectively, p = 0.01). Specificity was similar in Black versus White men (21.6% vs 27.4%, p = 0.32) and White versus Hispanic men (27.4% vs 17.5%, p = 0.14). The AUCs of the PIRADS added to standard clinical data (age, PSA and suspicious prostate exam) were similar when comparing Black versus White men (0.75 vs 0.73, p = 0.79) and White versus Hispanic men (0.73 vs 0.59, p = 0.11). The AUCs for the Base model and PIRADS model alone were statistically similar when comparing Black versus White men and White versus Hispanic men. Conclusions The accuracy of the PIRADS and clinical data for detecting GG2-5 PCa seems statistically similar across race. However, there is concern that PIRADS 2.0 has lower sensitivity in Hispanic men compared to White men. Prospective validation studies are needed.

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Section: Discussionmentioning

confidence: 56%

Section: Methodsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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Assessing the accuracy of multiparametric MRI to predict clinically significant prostate cancer in biopsy naïve men across racial/ethnic groups

et al. 2022

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Biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in a diverse, multiethnic population

Abramson,

DeMasi,

Zhu

et al. 2024

Abdom Radiol

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Purpose There is not yet satisfactory performance data comparing multiparametric MRI (mpMRI) versus biparametric MRI (bpMRI) for detecting prostate cancer (PCa), particularly in high-risk populations. We compared both protocols for detecting overall PCa and clinically significant PCa (CS-PCa; defined as Grade Group ≥ 2) in a multiethnic urban population. Methods We retrospectively reviewed electronic medical record data from men who underwent image-guided fusion prostate biopsy (FB) between 2016 and 2021 at our institution. Patient characteristics, Prostate Imaging Reporting and Data System (PI-RADS) scores, and FB outcomes were analyzed based on MRI protocol. Multivariate mixed-effects logistic regression models were used to examine associations of bpMRI versus mpMRI for detecting overall PCa and CS-PCa in targeted lesions, among all patients and stratified by race/ethnicity. Results Overall, 566 men (44.0% Non-Hispanic Black [NHB]; 27.0% Hispanic) with 975 PI-RADS 3–5 lesions on MRI underwent FB. Of these, 312 (55%) men with 497 lesions underwent mpMRI and 254 (45%) men with 478 lesions underwent bpMRI. On multivariate analyses among all men, the odds of detecting overall PCa (OR = 1.18, 95% CI: 1.05–3.11, p = 0.031) and CS-PCa (OR = 2.15, 95% CI: 1.16–4.00, p = 0.014) on FB were higher for lesions identified on bpMRI than mpMRI. When stratified by race/ethnicity, the odds of detecting overall PCa (OR = 1.86; p = 0.15) and CS-PCa (OR = 2.20; p = 0.06) were not statistically different between lesions detected on bpMRI or mpMRI. Conclusion BpMRI has similar diagnostic performance to mpMRI in detecting overall and CS-PCa within a racially/ethnically diverse population. BpMRI can be utilized for evaluating suspected CS-PCa among NHB and Hispanic men.

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Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy

et al. 2022

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A Comparison of Image-Guided Targeted Prostate Biopsy Outcomes by PI-RADS® Score and Ethnicity in a Diverse, Multiethnic Population

Cited by 5 publications

References 16 publications

Assessing the accuracy of multiparametric MRI to predict clinically significant prostate cancer in biopsy naïve men across racial/ethnic groups

Assessing the accuracy of multiparametric MRI to predict clinically significant prostate cancer in biopsy naïve men across racial/ethnic groups

Biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in a diverse, multiethnic population

Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy

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