A comparison of health-related quality of life in autonomic disorders: postural tachycardia syndrome versus vasovagal syncope

Hall, Juliette; Bourne, Kate; Sheldon, Robert S.; Vernino, Steven; Raj, Vidya; Ng, Jessica M.Y.; Okamoto, Luis E.; Arnold, Amy C.; Bryarly, Meredith; Phillips, Lauren; Paranjape, Sachin Y.; Raj, Satish R.

doi:10.1007/s10286-021-00781-x

Cited by 9 publications

(23 citation statements)

References 17 publications

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“…the first Prevention of Syncope Trial (POST1) ( 30 ) and ( 31 ); iv. the second Prevention of Syncope Trial (POST2) ( 10 , 30 ) and ( 53 )].…”

Section: Resultsmentioning

confidence: 99%

“…Despite finding that quality of life scores were reduced in older patients, syncope burden was not increased in older individuals, in fact, recurrence was more common in younger patients ( 39 ). When considering sex, SF-36 domain scores ( 56 ), PCS scores ( 28 ) and RAND-36 physical, mental and general health composite scores, as well as physical functioning, role physical, social functioning and pain domain scores ( 53 ) were increased in males with VVS. The negative relationship between SF-36 domain scores and increasing age was found to be stronger in women than in men with VVS ( 56 ).…”

Section: Resultsmentioning

confidence: 99%

“…POTS predominantly affects young women, 92% of POTS patients in the included studies in this review were female, making it difficult to evaluate the impact of sex on quality of life in POTS. One study evaluated the influence of sex on quality of life in this population, comparing quality of life between VVS and POTS patients ( 53 ). They showed that within the POTS group, males ( n = 12) scored lower than females ( n = 158) in the energy/fatigue domain and on the mental and general health composite scores of the RAND-36 ( 53 ).…”

Section: Resultsmentioning

confidence: 99%

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Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

Hockin

Heeney

Whitehurst

et al. 2022

Front. Cardiovasc. Med.

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PurposeSyncope (transient loss of consciousness and postural tone) and presyncope are common manifestations of autonomic dysfunction that are usually triggered by orthostasis. The global impact of syncope on quality of life (QoL) is unclear. In this systematic review, we report evidence on the impact of syncope and presyncope on QoL and QoL domains, identify key factors influencing QoL in patients with syncopal disorders, and combine available data to compare QoL between syncopal disorders and to population normative data.MethodsA comprehensive literature search of academic databases (MEDLINE (PubMed), Web of Science, CINAHL, PsycINFO, and Embase) was conducted (February 2021) to identify peer-reviewed publications that evaluated the impact of vasovagal syncope (VVS), postural orthostatic tachycardia syndrome (POTS), or orthostatic hypotension (OH) on QoL. Two team members independently screened records for inclusion and extracted data relevant to the study objectives.ResultsFrom 12,258 unique records identified by the search, 36 studies met the inclusion criteria (VVS: n = 20; POTS: n = 13; VVS and POTS: n = 1; OH: n = 2); 12 distinct QoL instruments were used. Comparisons of QoL scores between patients with syncope/presyncope and a control group were performed in 16 studies; significant QoL impairments in patients with syncope/presyncope were observed in all studies. Increased syncopal event frequency, increased autonomic symptom severity, and the presence of mental health disorders and/or comorbidities were associated with lower QoL scores.ConclusionThis review synthesizes the negative impact of syncope/presyncope on QoL and identifies research priorities to reduce the burden of these debilitating disorders and improve patient QoL.

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“…the first Prevention of Syncope Trial (POST1) ( 30 ) and ( 31 ); iv. the second Prevention of Syncope Trial (POST2) ( 10 , 30 ) and ( 53 )].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

Hockin

Heeney

Whitehurst

et al. 2022

Front. Cardiovasc. Med.

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“…Recurrent vasovagal syncope is the most common type of fainting, and can result in physical trauma and impaired quality of life [5]. Despite being frequent, vasovagal syncope remains difficult to treat in some patients.…”

Section: Midodrine For Vasovagal Syncope: Repurposing An Old Drug For An Age-old Reflexmentioning

confidence: 99%

The 2021 Nobel Prize in Medicine and its relevance to autonomic medicine—and other updates on recent autonomic research

2021

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“…It is a common cause of OI 1 in children, and the symptoms can seriously affect the patients’ quality of life. 2 …”

Section: Introductionmentioning

confidence: 99%

Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome

Wang¹,

Du²,

Li³

et al. 2021

IJGM

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Objective To investigate the influence of comorbidities on the prognosis of pediatric postural tachycardia syndrome (POTS). Methods In this retrospective cohort study, 275 children with POTS admitted to the Department of Pediatrics at Peking University First Hospital were recruited from 2016 to 2019 and followed up. The participants were divided into simple POTS (S-POTS, n=156 cases) and POTS with comorbidities (Co-POTS, n=119 cases) groups according to whether they were complicated with comorbidities. A Cox regression analysis was used to identify the prognostic risk factors for children with POTS, while Kaplan–Meier curves were applied to compare the cumulative symptom remission rate (CSRR) between the two groups. The rehospitalization of the children between the two groups was also compared to explore the influence of comorbidities. Results Twenty-one participants (7.6%) were lost during a median follow-up of 24 months. The Cox regression model showed that comorbidities and body mass index (BMI) were associated with the CSRR of the children with POTS. The CSRR of pediatric POTS alone was 1.748 times higher than that of patients with comorbidities, and the CSRR was decreased by 5.1% for each 1 kg/m 2 increase in BMI. The most common comorbidity in children with POTS in this study was allergic disorders, followed by the psychological diseases. The patients in the Co-POTS group had a lower CSRR than those in the S-POTS group (log rank P=0.0001). In addition, compared with those of the S-POTS group, the total number of rehospitalizations was high (P=0.001), and the total hospital stays were long in the Co-POTS group (P<0.001). Conclusion Complicating with comorbidities, pediatric patients with POTS had lower CSRR and more rehospitalizations than those without comorbidities. More attention should be given to comorbidities when managing pediatric POTS.

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A comparison of health-related quality of life in autonomic disorders: postural tachycardia syndrome versus vasovagal syncope

Cited by 9 publications

References 17 publications

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

The 2021 Nobel Prize in Medicine and its relevance to autonomic medicine—and other updates on recent autonomic research

Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome

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