A comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia

Taghon, Thomas; Masunga, Abigail; Small, Robert H.; Kashou, Nasser H.

doi:10.1111/pan.12606

Cited by 28 publications

(24 citation statements)

References 28 publications

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“…Brain development of rhesus macaques, corresponds closely to humans (neurodevelopment of rhesus monkeys at birth corresponds to that of a 6-month-old human 14,19 ), thus they are a highly relevant model for social functioning, complex behavior, and emotional state. So far, only three other studies have explored behavioral and/or cognitive outcomes after anesthesia exposure in young NHPs.…”

Section: Introductionmentioning

confidence: 91%

“…12 It is less clear whether a single anesthetic exposure, particularly of short duration, is enough to trigger long-term sequelae in young children. While some retrospective studies identified an increased risk for developmental or behavioral disorder diagnosis even after a single short general anesthetic event, 13,14 other studies produced ambiguous results 15 or observed no increased risk. 16 In fact, one recent study suggests no risk at all, not even after multiple anesthetic exposures.…”

Section: Introductionmentioning

confidence: 99%

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Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Coleman

Robertson

Dissen

et al. 2017

Survey of Anesthesiology

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Background-Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury and death as well as behavioral and cognitive impairments in young animals. Several, although not all, retrospective human studies of neurocognitive and behavioral disorders following childhood exposure to anesthesia suggest a similar association. Few studies have specifically investigated the effects of infant anesthesia exposure on subsequent

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Coleman

Robertson

Dissen

et al. 2017

Survey of Anesthesiology

View full text Add to dashboard Cite

show abstract

“…Therefore, the choices of drugs or treatment in children should be taken serious consideration. As shown by functional magnetic resonance imaging, general anesthetics used in children between 0 and 24 months of age would affect the development of cerebellum, cingulate gyrus, and paracentral lobule [16]. For examples, sevoflurane anesthesia reduces pro-social proteins oxytocin (OT) and arginine vasopressin (AVP) activities in the neonatal hippocampus and impairs social recognition memory formation and social discrimination ability in juvenile mice [17].…”

Section: Propofol Postnatal Administration Restricts Neurodevelopmentmentioning

confidence: 99%

Pten Inhibitor-bpV Ameliorates Early Postnatal Propofol Exposure-Induced Memory Deficit and Impairment of Hippocampal LTP

Wang

Chen

2015

Neurochem Res

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Early postnatal propofol administration has potential detrimental effects on hippocampal synaptic development and memory. Therapeutic method is still lack due to unknown mechanisms. In this study, a 7-day propofol protocol was applied to model anesthesia in neonatal mice. Phosphatase and tensin homolog deleted on chromosome ten (Pten) inhibitor bisperoxovanadium (bpV) was pre-applied before propofol to study its potential protection. After propofol application, Pten level increased while phospho-AKT (p-AKT) (Ser473) decreased in dorsal hippocampus. Interestingly, i.p. injection of Pten inhibitor reversed the decrease of p-AKT. Two months after administration, basal synaptic transmission, hippocampal long-term potentiation (LTP) and long-term memory were reduced in propofol-administrated mice. By contrast, i.p. injection of Pten inhibitor at a dose of 0.2 mg/kg/day before propofol reversed the detrimental effects due to propofol application. Consistently, bpV injection also reversed propofol application-induced decrease of synaptic plasticity-related proteins, including p-CamKIIα, p-PKA and postsynaptic density protein 95. Taken together, our results demonstrate that bpV injection could reverse early propofol exposure-induced decrease of memory and hippocampal LTP. bpV might be a potential therapeutic for memory impairment after early propofol postnatal application.

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“…While some retrospective studies identified an increased risk for developmental or behavioral disorder diagnosis even after a single short general anesthetic event, 13,14 other studies produced ambiguous results 15 or observed no increased risk. 16 In fact, one recent study suggests no risk at all, not even after multiple anesthetic exposures.…”

Section: Introductionmentioning

confidence: 99%

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

et al. 2017

View full text Add to dashboard Cite

Background Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury and death, as well as behavioral and cognitive impairments, in young animals. Several, although not all, retrospective human studies of neurocognitive and behavioral disorders after childhood exposure to anesthesia suggest a similar association. Few studies have specifically investigated the effects of infant anesthesia exposure on subsequent neurobehavioral development. Using a highly translational nonhuman primate model, the authors investigated the potential dose-dependent effects of anesthesia across the first year of development. Methods The authors examined the effects of single or multiple early postnatal isoflurane exposures on subsequent behavioral development in 24 socially reared rhesus macaques. Infants were exposed to 5 h of isoflurane anesthesia once, three times (ISO-3), or not at all (control). The authors assessed reflex development and anxiety using standardized tests. At approximately 1 yr, infants (n = 23) were weaned and housed indoors with 5 to 6 other subjects. The authors recorded their response to this move and reassessed anxiety. Results Compared to controls, animals exposed to repeated isoflurane (ISO-3) presented with motor reflex deficits at 1 month (median [range]: ISO-3 = 2 [1 to 5] vs. control = 5 [3 to 7]; P < 0.005) and responded to their new social environment with increased anxiety (median [range]: ISO-3 = 0.4 bouts/min [0.2 to 0.6]; control = 0.25 bouts/min [0.1 to 0.3]; P = 0.05) and affiliative/appeasement behavior (median [range]: ISO-3 = 0.1 [0 to 0.2]; control = 0 bouts/min [0 to 0.1]; P < 0.01) at 12 months. There were no statistically significant behavioral alterations after single isoflurane exposure. Conclusions Neonatal exposure to isoflurane, particularly when repeated, has long-term behavioral consequences affecting both motor and socioemotional aspects of behavior.

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A comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia

Cited by 28 publications

References 28 publications

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Pten Inhibitor-bpV Ameliorates Early Postnatal Propofol Exposure-Induced Memory Deficit and Impairment of Hippocampal LTP

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

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