A COMPARISON OF FOUR METHOD8 FOR DETERMINING VITAMIN C WITH A 25‐DAY, WEIGHT‐RESPONSE BIOASSAY¹

Isoascorbic Acid and Nutrition, Nutritional Studies with Isoascorbic Acid in the Guinea Pig

“…As Figure 2 indicates, guinea pigs supplemented with isoascorbic acid gained weight for approximately 4 weeks, but then began to lose weight and later died of scurvy. It appears that isoascorbic acid, being a potent reducing agent, protects the ascorbic acid stored in the body tissues, but, with the exhaustion of ascorbic acid reserves, it no longer produces a beneficial effect.…”