A Comparison of Five Different Treatment Regimens as the First‐Line Treatment of Helicobacter pylori in Turkey

Unler, Gulhan Kanat; Ozgur, Gokhan; Gokturk, Huseyin Savas; Karakoca, Aydın; Erinanç, Hilal

doi:10.1111/hel.12285

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…One from China found significantly superior eradication rates for a modified bismuth‐based therapy with rabeprazole, levofloxacin, and clarithromycin (91.7% vs 74.4%) . Another study from Turkey looked at a ST regimen enhanced with bismuth and looked at it on a retrospective basis in comparison with bismuth‐based quadruple treatment, ST with clarithromycin, ST with levofloxacin, and hybrid treatment, and found significantly better eradication (88.5%) in the bismuth‐enhanced ST group . A similar study also conducted in Turkey comparing conventional and ST with four other regimens found both concomitant and ST to be an effective treatment for H. pylori with bismuth‐based quadruple therapy and standard triple therapies being ineffective for eradication …”

Section: Sequential Therapymentioning

confidence: 95%

“…For example, studies were combined without subanalyzing data from different lengths of concomitant treatment and several of the comparisons that were made could be considered unequal in that treatment arms had different lengths of treatment. The adverse events and adherence to medications were not different between the two regimens in this meta-analysis.A number of other studies compared ST to bismuth-based quadru-and found significantly better eradication (88.5%) in the bismuth-enhanced ST group 37. A similar study also conducted in Turkey comparing conventional and ST with four other regimens found both concomitant and ST to be an effective treatment for H. pylori with bismuth-based quadruple therapy and standard triple therapies being ineffective for eradication 38.…”

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Treatment of Helicobacter pylori infection 2016

et al. 2016

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Many interesting articles have been published from different parts of the world over the last year assessing various issues around Helicobacter pylori eradication therapy. This article will address the published literature over the last year pertaining to the topic of treatment of H. pylori infection. The main themes that emerge are assessing the efficacy of standard triple therapy, as well as exploring new first-line treatments, mainly optimized nonbismuth-containing and bismuth-containing quadruple therapies with some promising data also emerging on dual therapy. There was also considerable progress in investigating antibiotic resistance rates with much more data emerging from varied parts of the world compared to recent years. Advances in the use of adjunctive therapies, especially probiotic therapies have also been made. Undoubtedly, the eradication of H. pylori remains a worthwhile goal to alleviate the burden of diseases caused by the complications of this infection, including dyspepsia, peptic ulcer disease, and gastric cancer.

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Section: Sequential Therapymentioning

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Treatment of Helicobacter pylori infection 2016

et al. 2016

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“…The H. pylori eradication strategy is based on a combination therapy of antibiotics and acid suppressants, i.e., proton pump inhibitors (PPIs). The choice of an antibiotic depends on several factors, namely local resistance profiles, prior antibiotic therapy, history of allergy to specific antibiotics, patient age, renal and hepatic function and comorbid conditions, drug costs, adverse effects, and ease of administration [ 7 , 8 ]. Due to the growing increase in antibiotic resistance, the efficacy of antimicrobials in eradicating H. pylori infection has significantly decreased.…”

Section: Introductionmentioning

confidence: 99%

Effect of Statins on Helicobacter pylori Eradication Rate: A Systematic Review and Meta-Analysis

Rajabnia

Sadeghi

Abdi

et al. 2021

GE Port J Gastroenterol

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Statins have been used as adjuvants to standard treatment in order to increase the eradication ratesof Helicobacter pylori infection. This study aimed to summarize the results of the efficacy of adding statins to standard treatments used for the eradicationof H. pylori infection. We conducted a systematic search using a comprehensive combination of keywords in PubMed/MEDLINE, Web of Science, and Scopus to retrieve relevant studies from 1990 to 2020. The estimate of pooled relative risk (RR), as the effect measure, was calculated using random effects meta-analyses in Stata 14. We finally included 5 studies (all of them were randomized controlled trials). The meta-analysis of all studies showed that the pooled RR (95% confidence interval) was 1.03 (0.64–1.68) in the random effects model, which was not statistically significant. In other words, based on our meta-analysis, the addition of statins as an adjuvant therapy to the standard treatment regimens does not increase the rate of H. pylori eradication. However, further evidence is needed to confirm this result as the number of available studies was small.

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Efficiency measurement on teaching hospitals: an integrative review

Almeida

Moreira

Bermejo

et al. 2023

Preprint

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Background The complexity of hospital management drives the improvement of scientific instruments available to measure their organizational efficiency. The incorporation of financial aspects as an agenda for the improvement of models for evaluating the efficiency of hospitals, and of the quality dimension have been indicated as gaps. Particularly, teaching hospitals are less profitable than other hospitals due to their teaching and research missions. Thus, this paper presents an integrative review of the literature about measuring the efficiency of teaching hospitals from 2011 to January 2023 to outline the main achievements, challenges, and recommendations in this research field. Methods We offer an integrative review across Scopus, ScienceDirect, Web of Science, Inderscience, and Springer Link databases. The search in databases generated 384 records, after removing duplicates, and following the PRISMA guidelines, 30 studies were considered eligible for this study. Results The studies included in this review revealed the scarcity of evaluation models tailored to the reality of teaching hospitals. Data Envelopment Analysis is the most frequently used evaluation method. There is a greater occurrence of inputs related to personnel and the most frequent outputs were those related to the number of visits and surgeries. We did not identify quality-oriented inputs, but we observed outputs (service level, and medical service satisfaction). The economic-financial inputs are related to expenses and costs, and the outputs are related to revenue, profit, and Resource Intensity Weight. Conclusions This study contributed to the improvement of the research field by pointing a direction for the advance of the measurement models. It is recommendable a combination of economic-financial indicators and quality measures. Regarding the financial dimension, the recommendation is to analyze the Return on Investment, and in the scope of the quality dimension, to verify the staff inputs from the point of view of the quality of the workforce. Also, there is a broken path for future research to consider input-oriented to physical and technological structure to measure the efficiency of teaching hospitals. We recommend developing a specific model to measure the efficiency of teaching hospitals to target the limitations appointed in this study.

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A Comparison of Five Different Treatment Regimens as the First‐Line Treatment of Helicobacter pylori in Turkey

Abstract: Bismuth-enhanced sequential therapy can be recommended to overcome resistance.

Cited by 4 publications

References 43 publications

Treatment of Helicobacter pylori infection 2016

Treatment of Helicobacter pylori infection 2016

Effect of Statins on <b><i>Helicobacter pylori</i></b> Eradication Rate: A Systematic Review and Meta-Analysis

Efficiency measurement on teaching hospitals: an integrative review

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