A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation

Berlyne, Graham S.; Parameswaran, Krishnan; Kamada, Dennis; Efthimiadis, A.; Hargreave, Frederick E.

doi:10.1067/mai.2000.109622

Cited by 167 publications

(118 citation statements)

References 31 publications

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“…However, our results are consistent with those of Berlyne et al [50] comparing eNO to induced sputum, and are in accordance with the hypothesis of a similar physiological process between atopic and non-atopic asthma. Furthermore, the eNO discrepancy between non-atopic asthma with rhinitis and non-atopic asthma without rhinitis could be due to a difference of frequency and intensity of stimulation to an unknown allergen [51].…”

Section: Discussionsupporting

confidence: 94%

Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population‐based sample of children

Jouaville¹,

Annesi‐Maesano

Nguyễn³

et al. 2003

Clin Experimental Allergy

116

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SummaryBackground Exhaled nitric oxide (eNO) has attracted increasing interest as a non-invasive marker of airway inflammation in asthma. However, little evidence exists on the influences exerted on eNO by the interrelations among atopic status, asthma and rhinitis. Methods Among the 1156 children who participated in a large-scale epidemiological survey on asthma and allergies (ISAAC II: International Study of Asthma and Allergies in Childhood Phase II) in the city of Clermont-Ferrand, 53 asthmatics without corticosteroid treatment and 96 nonasthmatics were invited to perform eNO and skin prick tests (SPTs) to 12 common allergens. Results Atopic asthmatic children had higher eNO than non-atopic asthmatic children (28.979.1 vs. 17.1713.1 p.p.b.; P 5 0.0004) with a significant increase when one SPT or more are positive (26.577.8 vs. 17.1713.1 p.p.b.; P 5 0.03). Similarly, non-asthmatic, atopic subjects had higher eNO than non-atopic subjects with a significant increase when two SPTs or more are positive (19.479.8 vs. 11.7 76.7 p.p.b.; P 5 0.003). In the case of equal levels of positive SPTs (0, 1, X2), asthmatic children always had higher eNO than non-asthmatic ones. Furthermore, among non-asthmatic children, the eNO level increased only in atopics who had rhinitis (20.7713 vs. 12.576.4 p.p.b. in atopic controls (subjects without rhinitis and asthma) and 12.376.6 p.p.b. in non-atopic controls; P 5 0.001), whereas among asthmatic children, eNO level increased in atopics independently of rhinitis (28.279.5 p.p.b. in those with rhinitis and 30.978.1 p.p.b. in those without) as well as in nonatopics with rhinitis (22.5717.2 p.p.b.). Conclusions Our data suggest that besides atopy and asthma, allergic rhinitis should also be taken into account in the assessment of eNO.

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Section: Discussionsupporting

confidence: 94%

Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population‐based sample of children

Jouaville¹,

Annesi‐Maesano

Nguyễn³

et al. 2003

Clin Experimental Allergy

116

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“…Although the severity of disease varies among patients and over time in the same patient, asthma can be fatal, accounting for approximately one death per 100,000 Americans. 5 Diagnosing asthma is challenging. The common symptoms, such as shortness of breath, wheezing, and cough, are relatively non-specific.…”

Section: Introduction Backgroundmentioning

confidence: 99%

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

Wang¹,

Pianosi²,

Keogh³

et al. 2017

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“…O valor médio do FENO na amostra é de 38,19 (27,74) ppb e a maioria dos indivíduos encontra-se distribuído pelas classes normal (n = 26; 35,6%) e elevado (n = 48; 47,5%) do FENO. Relativamente à terapêutica, a maioria dos indivíduos não toma medicação (n = 34; 33,7%).…”

Section: Resultsunclassified

“…24 Vários estudos revelaram uma correlação positiva entre o FENO e biópsia brônquica 15,25 e a análise de expetoração. [26][27][28] A American Thoracic Society (ATS) concluiu em 2011 que o FENO tem um papel importante na deteção da inflamação eosinófila das vias aéreas, na determinação da resposta aos corticóides, na monitorização da inflamação das vias aéreas para determinar a necessidade de utilização de corticóides e para verificar a adesão à terapêutica com corticóides.…”

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Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

et al. 2014

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(1) = 8,71; OR = 2,33; p = 0,003) sobre a probabilidade de mudar de nível de controlo da asma. Por cada nível de fração exalada de óxido nítrico incrementado o odds de passar a não controlada é 2,33 vezes superior. Discussão: A probabilidade de uma criança asmática mudar o seu nível de controlo da asma, de 'controlada' para 'parcialmente controlada/não controlada', tendo em consideração uma alteração no seu nível da fração exalada de óxido nítrico, aumenta 133%. Palavras-chave: Criança; Asma; Expiração; Óxido Nítrico; Portugal. AbSTRACTIntroduction: Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma. Material and Methods:Observational, analytical and cross-sectional study of children with asthma, 6-12 years-old, followed in the Outpatient Respiratory Pathology of Braga Hospital. Sociodemographic and clinical information were collected through a questionnaire. fractional exhaled nitric oxide and peak expiratory flow were determined by portable analyzer Niox Mino ® and flow meter, respectively. Results: The sample is constituted by 101 asthmatic children, 63 (62.4%) of males and 38 (37.6%) females. The mean age of participants in the sample is 9.18 (1.99) years. The logistic regression performed with the cutoff value obtained by ROC curve, revealed that fractional exhaled nitric oxide (b FENO classes = 0.85; χ 2 Wald (1) = 8.71; OR = 2.33; p = 0.003) has a statistical significant effect on the probability of changing level of asthma control. The odds ratio of going from "controlled" to "partly controlled/uncontrolled" is 2.33 per each level of fractional exhaled nitric oxide. Discussion: The probability of an asthmatic children change their level of asthma control, from 'controlled' to 'partly controlled/uncontrolled', taking into account a change in their fractional exhaled nitric oxide level, increases 133%.

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A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation

Cited by 167 publications

References 31 publications

Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population‐based sample of children

Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population‐based sample of children

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

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