A comparison of endometrial and subendometrial vascularity assessed by three-dimensional ultrasonography and power Doppler angiography between healthy fertile women and women with unexplained primary recurrent miscarriage

Chen, Leining; Song, Qisheng; Li, Hong; Chen, Cuihua; Xing, Fu-qi; Yu, Yongfu

doi:10.1016/j.fertnstert.2010.09.034

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…Furthermore, impaired uterine perfusion and decreased vascularity have been reported during the mid-luteal phase of the menstrual cycle in patients with RPL and recurrent miscarriage, respectively. Impaired uterine perfusion showed adverse effects on reproductive functions (17)(18)(19)(20). It has been demonstrated that patients with RIF have a higher uterine artery PI in comparison with the examined infertile control cases during the mid-luteal phase before their first IVF trial (21).…”

Section: Discussionmentioning

confidence: 99%

Alterations of Uterine Blood Flow During the Follicular Phase in Patients With Recurrent Implantation Failure: A Doppler Ultrasonographic Study

Amini

Ranjkesh

Nikanfar

et al. 2021

International Journal of Women’s Health and Reproduction Scienc

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Objectives: The dynamics of blood flow in the endometrium plays a crucial role during the implantation process. This study aimed to assess the uterine perfusion during the follicular phase in patients with a history of recurrent implantation failure (RIF) and healthy fertile women using the transvaginal ultrasound color Doppler method. Materials and Methods: To this end, 50 patients with RIF and 50 age-matched healthy fertile women were recruited in this case-control study. The transvaginal color Doppler ultrasonography was used to evaluate the pulsatility index (PI) and resistance index (RI) of the uterine, arcuate, and sub-endometrial arteries during the follicular phase in both groups. Results: The RI and PI of both right and left uterine arteries were higher in the RIF group compared to the fertile women (P<0.05). Our results showed that the PI and RI of sub-endometrial blood flow and the RI of arcuate arteries were substantially higher in the group with a history of RIF in comparison with the control group. However, the PI of arcuate arteries was not significantly different between the groups. Conclusions: Adequate uterine perfusion and sub-endometrial blood flow are necessary to achieve successful implantation and pregnancy since our results demonstrated the higher resistance of uterine and sub-endometrial arteries in patients with a history of RIF. Thus, the assessments of uterine perfusion indices during the follicular phase could be used as a non-invasive method in the evaluation of patients with RIF.

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Section: Discussionmentioning

confidence: 99%

Alterations of Uterine Blood Flow During the Follicular Phase in Patients With Recurrent Implantation Failure: A Doppler Ultrasonographic Study

Amini

Ranjkesh

Nikanfar

et al. 2021

International Journal of Women’s Health and Reproduction Scienc

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“…A previous study compared endometrial vascularization in healthy fertile women in RPL cases using 3-dimensional Doppler angiography, and reported a significant decrease in vascularization in the RPL cases (12). Similarly, another indirect comparative study by Doppler angiography reported an impairment of endometrial vascularization in antiphospholipid antibody-positive RPL cases (13).…”

Section: Discussionmentioning

confidence: 96%

Assesment of Endometrial Vascularization with Immunohistochemical CD34 Assay in Recurrent Pregnancy Loss: A Case Control Study

Aydın

Usta

2017

Gynecol Obstet Reprod Med

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OBJECTIVES:We compared the endometrial vascularization in hysteroscopic endometrial samplings between recurrent pregnancy loss (RPL) and control group. STUDY DESIGN:We prospectively evaluated hysteroscopic endometrial samplings from recurrent pregnancy loss and control groups. CD34 transmembrane protein was used for evaluating endometrial vascularization. The vascularization was assessed based on thickness of vessels, diameter of the largest vessel, and number of vessels per mm 2 in CD34-stained slides. RESULTS:There was no significant difference in demographic findings and vascularization, such as largest vessel diameter (p: 0.572), and number of vessels per mm 2 (p: 0.982) between the two groups. CONCLUSION:The cycling endometrium is a highly angiogenic tissue and may play a role in the etiology of RPL. However, we find a weak relationship between endometrial vascularization and recurrent pregnancy loss.

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“…All three vascularity indices were significantly higher in the miscarriage group compared to the luteal group, a finding that is at odds with the study by Chen et al who showed that women with recurrent miscarriages had significantly lower VI, FI, and VFI compared to normal fertile women. 15 In another study of 51 women, Tan et al in 2015 showed that lower vascular indexes were associated with unexplained recurrent miscarriages. 6 An earlier study in 2011, on 134 patients also showed the same result.…”

Section: Discussionmentioning

confidence: 98%

“…6 An earlier study in 2011, on 134 patients also showed the same result. 15 Studies have shown that patients with recurrent miscarriages demonstrated lower endometrial-subendometrial vascularization indices. 16 The differences in these observations and ours is most likely due to the time of the imaging.…”

Section: Discussionmentioning

confidence: 99%

An investigation of endometrial vascularity in normally menstruating women and those in other physiological states using 3D ultrasound imaging

Khan,

Al‐Motawa,

Halabi

et al. 2024

Intl J Gynecology & Obste

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ObjectivesThis study aimed to determine the normal vasculature indices of the endometrium and to correlate them with those in various physiological states.MethodsWomen undergoing ultrasound at the Feto‐Maternal Center, Qatar in 2020–2021 as part of their gynecologic evaluation were enrolled into the study. They were divided into those with normal menses and no additional pathology, those following spontaneous miscarriage, postpartum and menopausal. Three‐dimensional (3D) evaluation of the endometrial vasculature was done and the parameters quantified included vascularization index (VI), flow index (FI), vascularization flow index (VFI), endometrial thickness, endometrial volume and uterine volume. JASP, an open‐source statistical analysis software, was used for analysis and an independent t‐test to compare the vascularity indices. A multivariate regression analysis was also done to look at the factors affecting the endometrial vascular indices within the luteal phase.ResultsA total of 461 women were studied: 122 in the follicular phase, 199 in the luteal phase, 90 after a spontaneous miscarriage, 29 postpartum, and 16 menopausal. The vascularity indices were highest after miscarriage and lowest postnatally. There were no significant effects of age, gravida, para, or abortions on VI and VFI. However, there was a significant positive effect of age on FI (P = 0.019) There was a significant increase in endometrial volume and thickness in the luteal phase as compared to follicular phase (P < 0.01), but there was no difference in the vascularity indices. The uterine and endometrial volume in the postnatal group were nearly double that of the luteal group (P value <0.01 and 0.014, respectively). There was a significant decrease in flow index in the postnatal group compared to the luteal group (P < 0.01), suggesting low flow intensity in the postnatal group.ConclusionsEndometrial vascular indices measured using 3D Doppler can be used to determine normal vascular indices and vary with physiological states such as after miscarriages, postnatally and in the menopausal states.

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A comparison of endometrial and subendometrial vascularity assessed by three-dimensional ultrasonography and power Doppler angiography between healthy fertile women and women with unexplained primary recurrent miscarriage

Cited by 13 publications

References 12 publications

Alterations of Uterine Blood Flow During the Follicular Phase in Patients With Recurrent Implantation Failure: A Doppler Ultrasonographic Study

Alterations of Uterine Blood Flow During the Follicular Phase in Patients With Recurrent Implantation Failure: A Doppler Ultrasonographic Study

Assesment of Endometrial Vascularization with Immunohistochemical CD34 Assay in Recurrent Pregnancy Loss: A Case Control Study

An investigation of endometrial vascularity in normally menstruating women and those in other physiological states using 3D ultrasound imaging

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