A Comparison of Dual-Energy Digital Radiography and Screen-Film Imaging in the Detection of Subtle Interstitial Pulmonary Disease

Barnes, G.T; Ea, Sabbagh; Chakraborty, Debjani; Ph, Nath; Rf, Luna; Sanders, Colleen; Fraser, Robert G.

doi:10.1097/00004424-198908000-00003

Cited by 8 publications

(2 citation statements)

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“…It has been shown (84), for example, to improve detection of coronary artery and other cardiac calcifications (Fig 10). On the other hand, dual-energy imaging does not seem to improve detection of interstitial disease (85).…”

Section: Dual-energy Subtraction Imagingmentioning

confidence: 99%

Recent Advances in Chest Radiography

McAdams¹,

Samei²,

Dobbins³

et al. 2006

Radiology

184

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There have been many remarkable advances in conventional thoracic imaging over the past decade. Perhaps the most remarkable is the rapid conversion from film-based to digital radiographic systems. Computed radiography is now the preferred imaging modality for bedside chest imaging. Direct radiography is rapidly replacing film-based chest units for in-department posteroanterior and lateral examinations. An exciting aspect of the conversion to digital radiography is the ability to enhance the diagnostic capabilities and influence of chest radiography. Opportunities for direct computer-aided detection of various lesions may enhance the radiologist's accuracy and improve efficiency. Newer techniques such as dual-energy and temporal subtraction radiography show promise for improved detection of subtle and often obscured or overlooked lung lesions. Digital tomosynthesis is a particularly promising technique that allows reconstruction of multisection images from a short acquisition at very low patient dose. Preliminary data suggest that, compared with conventional radiography, tomosynthesis may also improve detection of subtle lung lesions. The ultimate influence of these new technologies will, of course, depend on the outcome of rigorous scientific validation.

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Section: Dual-energy Subtraction Imagingmentioning

confidence: 99%

Recent Advances in Chest Radiography

McAdams¹,

Samei²,

Dobbins³

et al. 2006

Radiology

184

View full text Add to dashboard Cite

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“…DE imaging allows selective material decomposition in projection images by exploiting the difference in energy-dependent attenuation coefficient between materials of different atomic number -e.g., the decomposition of "bone-only" and "soft-tissue-only" components from projections acquired at low and high kVp. [1][2][3][4][5][6] For thoracic imaging, this capability potentially resolves the two main factors that currently limit the detection and classification of early-stage lung cancer nodules: first, selective removal of overlying bony anatomy significantly increases lung nodule conspicuity and promises increased sensitivity compared to conventional radiography; second, fine material characterization allows calcified nodules to be clearly identified and promises increased specificity compared to low-dose CT. [7][8][9] Hence, the development of high-performance DE imaging systems based on flat-panel detectors is an important and burgeoning area of research and clinical implementation.…”

Section: Introductionmentioning

confidence: 99%

High-performance dual-energy imaging with a flat-panel detector: imaging physics from blackboard to benchtop to bedside

Siewerdsen¹,

Shkumat

Dhanantwari

et al. 2006

SPIE Proceedings

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The application of high-performance flat-panel detectors (FPDs) to dual-energy (DE) imaging offers the potential for dramatically improved detection and characterization of subtle lesions through reduction of "anatomical noise," with applications ranging from thoracic imaging to image-guided interventions. In this work, we investigate DE imaging performance from first principles of image science to preclinical implementation, including: 1.) generalized task-based formulation of NEQ and detectability as a guide to system optimization; 2.) measurements of imaging performance on a DE imaging benchtop; and 3.) a preclinical system developed in our laboratory for cardiac-gated DE chest imaging in a research cohort of 160 patients. Theoretical and benchtop studies directly guide clinical implementation, including the advantages of double-shot versus single-shot DE imaging, the value of differential added filtration between low-and high-kVp projections, and optimal selection of kVp pairs, filtration, and dose allocation. Evaluation of task-based NEQ indicates that the detectability of subtle lung nodules in double-shot DE imaging can exceed that of single-shot DE imaging by a factor of 4 or greater. Filter materials are investigated that not only harden the high-kVp beam (e.g., Cu or Ag) but also soften the low-kVp beam (e.g., Ce or Gd), leading to significantly increased contrast in DE images. A preclinical imaging system suitable for human studies has been constructed based upon insights gained from these theoretical and experimental studies. An important component of the system is a simple and robust means of cardiacgated DE image acquisition, implemented here using a fingertip pulse oximeter. Timing schemes that provide cardiacgated image acquisition on the same or successive heartbeats is described. Preclinical DE images to be acquired under research protocol will afford valuable testing of optimal deployment, facilitate the development of DE CAD, and support comparison of DE diagnostic imaging performance to low-dose CT and radiography.

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