A Comparison of Diprivan and Thiopental for the Induction of Anesthesia

Mouton, S.; Bullington, J.; Davis, Leah; Fisher, Kim; Ramsey, S.; Wood, Michael

doi:10.1097/00000542-198509001-00364

Cited by 10 publications

(5 citation statements)

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“…The mean induction time was statistically similar in both our study groups. This finding matches with the results of previous researchers such as Mouton et al, [4] Edelist, [5] and Grant and Mackenzie. [6] Many of the previous studies [4,[6][7][8] have reported the pain on propofol injection to be around 25%-27%.…”

Section: Discussionsupporting

confidence: 93%

“…Table 2 shows that apnea of more than 30 s was common (50%) with propofol induction and required assisted ventilation in such patients, whereas only 30% patients of thiopentone required such attention. The studies of Key et al, [4] Mouton et al, [6] and Mackenzie et al [9] support our findings. Table 2 also shows that involuntary movements were more in the propofol group, whereas hiccup/cough was more in the thiopentone group.…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, such pain was reported in less than 5% patients of thiopentone group by previous reports, whereas we found it to be 6%. [4,[6][7][8] Thus, propofol causes feeling of burning/pain on injection in significant number of patients, when compared with thiopentone but without any evidence of thrombophlebitis at fourth postoperative hour. Table 2 shows that apnea of more than 30 s was common (50%) with propofol induction and required assisted ventilation in such patients, whereas only 30% patients of thiopentone required such attention.…”

Section: Discussionmentioning

confidence: 99%

“…Table 2 also shows that involuntary movements were more in the propofol group, whereas hiccup/cough was more in the thiopentone group. Mouton et al [4] and Grant and Mackenzie [6] also reported that involuntary movements were more in the propofol group when compared with the thiopentone group. Sampson et al [8] and Reader and Misvaer [10] reported hiccups/cough more in the thiopentone group when compared with the propofol group.…”

Section: Discussionmentioning

confidence: 99%

“…However, there was statistically significant fall in systolic and diastolic blood pressures in the propofol group when compared with the thiopentone group at the end of first, second, and third minutes after induction. Mouton et al, [4] Grant and Mackenzie, [6] and Grounds et al [11] also found that propofol markedly decreased blood pressure parameters.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of induction and recovery profiles of intravenous propofol and thiopentone anesthesia

Shende¹,

Bachewar²,

Patwardhan³

2016

Int J Med Sci Public Health

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Background: In day care anesthesia, postoperative recovery is of importance. In addition to economical gains, the inconvenience, which is avoided, and the time gained by the patient to resume daily life are notable. Objective: To compare the induction and recovery profiles of the propofol with thiopentone in day care patients. Materials and Methods: A prospective, randomized, patient-blinded, parallel-group, noncrossover trial carried out in Department of Anesthesia of our teaching hospital. Hundred females of ASA group I and II aged between 20 and 45 years, scheduled for minor gynecological procedures, were randomly allocated to two groups that received either propofol or thiopentone. Induction time was measured. The occurrences of cough/hiccup, pain, apneic episodes, twitching, or movements during induction and maintenance were recorded. Blood pressure, SpO 2 , and pulse rate were recorded at intervals. During recovery, waking time, talking time, sitting time, and standing time were observed. Psychomotor recovery was studied by the performance of aiming test and dexterity test. The patients were observed for complaints of any adverse effects up to 4 h of recovery. Independent statistician applied unpaired t-test, repeated-measures ANOVA, and Fischer's exact test, according to requirements, using GraphPad Prism, 5.01. Result: In this study, the mean induction dose of propofol was 2.31 ± 0.01 mg/kg and thiopentone was 4.55 ± 0.02 mg/kg. The mean induction time was 30.16 ± 1.23 and 29.56 ± 1.16 min, respectively. Apnea was 50% with propofol induction, and only 30% with thiopentone. Involuntary movements were more in propofol group, whereas hiccup/cough was more with thiopentone. There was significant fall in blood pressures in propofol group during induction. Recovery was faster with propofol, than thiopentone. Postoperative aiming scores and dexterity time in thiopentone group were significantly low than those in the propofol group. Comparison with baseline scores, at first and second hours, showed significantly low scores in thiopentone group, but at 4 h, the difference was not statistically significant in either group. Adverse effects were more common with thiopentone. Conclusion: The recovery characteristics of propofol are superior to those of thiopentone. The return of psychomotor performance and cognitive functions are more rapid in propofol group.

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