A comparison of diagnostic imaging modalities for colorectal liver metastases

Bonanni, L.; Carino, Nicola de’Liguori; Deshpande, Rahul; Ammori, Basil J.; Sherlock, David; Valle, Juan W; Tam, E.; O’Reilly, Derek

doi:10.1016/j.ejso.2013.12.023

Cited by 35 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 MRI is generally more sensitive and can provide more complete characterization of liver lesions than CT. While MRI is well suited for preoperative planning, it has not found widespread use for intraoperative surgical guidance due to its high cost, large footprint, relatively long imaging times, and issues with false positive contrast enhancement.…”

mentioning

confidence: 99%

Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles

et al. 2016

View full text Add to dashboard Cite

Complete surgical resection is the first-line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise visualization of tumor margins, and detection of otherwise invisible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue, but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using Indocyanine Green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer.

show abstract

mentioning

confidence: 99%

Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Imaging of the liver with IOUS has been shown to be the most sensitive liver imaging modality and when compared with preoperative imaging techniques and correlates most closely with histology . IOUS without contrast has a sensitivity of 95–99% and specificity of 95–100% for detecting the number of lesions seen on preoperative imaging techniques .…”

Section: Discussionmentioning

confidence: 99%

Intraoperative ultrasound for the colorectal surgeon: current trends and barriers

Walker

Bamford

Finch-Jones

2017

ANZ Journal of Surgery

View full text Add to dashboard Cite

Up to two thirds of patients diagnosed with colorectal cancer (CRC) develop colorectal liver metastases (CRLMs) and one quarter of patients present with synchronous metastases. Early detection of CRLM widens the scope of potential treatment. Surgery for CRLM offers the best chance of a cure. Current preoperative staging of CRC relies on computerized tomography and magnetic resonance imaging. Intraoperative ultrasound (IOUS) scans and contrast-enhanced IOUS (CE-IOUS) have been demonstrated to detect additional metastases not seen on routine preoperative imaging. IOUS is not widely used by colorectal surgeons during primary resection for CRC. Confident use of IOUS/CE-IOUS during primary resection of CRC may improve decision-making by providing the most sensitive form of liver staging even when compared with magnetic resonance imaging. This may be particularly important in the era of laparoscopic resections, where the colorectal surgeon loses the opportunity to palpate the liver. There are several implied barriers to the routine use of IOUS/CE-IOUS by colorectal surgeons. These include time pressure, familiarity with techniques, a perceived learning curve, cost implications and limitation of the modality due to operator variations. Inclusion of IOUS in the training of colorectal surgeons and further investigation of potential benefits of IOUS/CE-IOUS could potentially reduce these barriers, enabling usage during primary resection for CRC to become more widespread.

show abstract

“…Long-term overall survival (OS) rates have improved with time, with reports of five-year survival now ranging between 35% and 58% [4][5][6][7][8]. Safe and effective surgery is now routine due to enhancements in surgical techniques, such as intraoperative ultrasonography, better hemostasis with pedicle clamping, and lower central venous pressure, availability of novel devices for parenchymal transection, parenchyma sparing techniques associated with anatomical resections, pre-operative portal vein embolization for hypertrophy of future liver remnants, ablation techniques, and staged hepatic resection [4,[9][10][11][12][13][14][15]. The outcomes have also improved because of more effective systemic chemotherapy and staging of cancer migration with more modern imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

Patient selection for the surgical treatment of resectable colorectal liver metastases

Araújo

Riechelmann

Fong

2016

Journal of Surgical Oncology

View full text Add to dashboard Cite

Advances in surgery and chemotherapy regimens have increased the long-term survival of patients with colorectal liver metastases (CRLM). Although liver resection remains an essential part of any curative strategy for resectable CRLM, chemotherapy regimens have also improved the long-term outcomes. However, the optimal timing for chemotherapy regimens remains unclear. Thus, this review addressed key points to aid the decision-making process regarding the timing of chemotherapy and surgery for patients with resectable CRLM. J. Surg. Oncol. 2017;115:213-220. © 2016 Wiley Periodicals, Inc.

show abstract

A comparison of diagnostic imaging modalities for colorectal liver metastases

Cited by 35 publications

References 19 publications

Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles

Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles

Intraoperative ultrasound for the colorectal surgeon: current trends and barriers

Patient selection for the surgical treatment of resectable colorectal liver metastases

Contact Info

Product

Resources

About