A Comparison of Dermal and Cadaveric Pericardial Grafts in the Modified Horton-Devine Procedure for Peyronie’s Disease

Chun, Judy; McGREGOR, Andy; Krishnan, Raishma; Carson, Culley C.

doi:10.1016/s0022-5347(05)66106-x

Cited by 89 publications

(70 citation statements)

References 31 publications

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“…61,62 The pericardial grafts are thin, strong, do not contract and have virtually absent reported infection or rejection rate. Chun et al 63 performed a comparison of dermal and nontutoplast processed human cadaveric pericardial grafts in the modified Horton-Devine procedure. Overall, 92% were able to achieve successful coitus with or without assistance.…”

Section: Tunical Lengthening Procedures (Incision or Partial Excisionmentioning

confidence: 99%

“…Satisfaction rates were similar and those who underwent pericardial grafting enjoyed shorter operative times as well as decreased morbidity associated with the absence of a graft donor site. 63 The SIS grafts have similar advantages to pericardium, except that there have been reports of graft contraction of up to 25% with associated recurrent curvature in the 37%-75% range. 22,47,[64][65][66][67] Other reported postoperative complications with SIS grafts include hematoma at 26% as well as an infection rate of 5%.…”

Section: Tunical Lengthening Procedures (Incision or Partial Excisionmentioning

confidence: 99%

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Surgery for Peyronie's disease

Levine¹,

Larsen²

2012

Asian J Androl

110

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Peyronie's disease (PD) is most simply referred to as a fibrotic wound-healing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing and shortening, which may compromise sexual function. Although a variety of non-surgical treatments have been suggested, none to date offer a reliable and effective correction of the penile deformity. As a result, surgery remains the gold standard treatment option, offering the most rapid and reliable treatment which will be the focus of this article. We review the preoperative evaluation, surgical algorithm, graft materials and postoperative management of PD. Outcomes for tunical shortening, tunical lengthening and penile prosthesis placement for penile straightening are reviewed. Tunica albuginea plication is the preferred method of straightening for men with adequate rigidity and less severe disease defined as curvature less than 706 without narrowing/hinging. Men who have more severe, complex deformity, but maintain strong preoperative erectile function should be considered candidates for straightening with plaque incision or partial excision and grafting. Finally, for those men who have inadequate rigidity and PD, penile prosthesis placement with straightening is the best approach to address both problems. Keywords: penile prosthesis; Peyronie's disease, penile reconstruction; plaque excision and grafting; plaque incision; tunica albuginea plication INTRODUCTION Peyronie's disease (PD) is most simply referred to as a fibrotic woundhealing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing, shortening and painful erections. 1 The perceived loss of length and girth is often more disturbing than the curvature itself, all of which can lead to moderate to severe depressive symptoms, emotional, and relationship problems. 2,3 Despite a myriad of treatment options, PD remains a considerable therapeutic dilemma due to several factors including an incomplete understanding of its etiopathophysiology and the relative paucity of randomized, placebo-controlled trials. A general explanation of this disorder, which has gained acceptance, is that PD is a disorder in which genetically susceptible individuals experience a localized response to endogenous factors such as tumor growth factor-b, which are released in response to microtrauma. This can lead to biological transformation of cells within the tunica albuginea, cell cycle dysregulation, genotypic changes and increased expression of cytokines and free radicals. This inflammatory response leads to unregulated extracellular matrix deposition including fibronectin and collagen, and ultimately plaque scar formation, which does not appear to undergo proper scar remodeling, leaving an inelastic segment in the involved tunica albuginea. [4][5][6][7][8][9] Although a variety of non-surgical treatments have been suggested, none offer a r...

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Section: Tunical Lengthening Procedures (Incision or Partial Excisionmentioning

confidence: 99%

Section: Tunical Lengthening Procedures (Incision or Partial Excisionmentioning

confidence: 99%

Surgery for Peyronie's disease

Levine¹,

Larsen²

2012

Asian J Androl

110

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“…[1][2][3][4] There have been no reported cases of tissue rejection, infection, or reactive cyst formation in any of these series. We describe a previously unreported complication and subsequent surgical therapy of cyst formation and graft contraction in a Tutoplast human cadaveric pericardial graft following surgical correction of Peyronie's penile curvature.…”

Section: Introductionmentioning

confidence: 84%

Inclusion cyst and graft contraction in Tutoplast human cadeveric pericardium following Peyronie's grafting: a previously unreported complication

Thiel

Broderick

2005

Int J Impot Res

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Tutoplast human cadaveric pericardium has been utilized safely and successfully in numerous series of tunica albuginea grafting for Peyronie's curvature without reported rejection, cyst formation, or foreign body reaction. We describe a previously unreported complication of inclusion cyst formation and graft contraction in a 40-year-old white male following Tutoplast human cadaveric pericardial graft surgical correction of Peyronie's curvature. The complication was successfully treated with surgical graft excision and replacement with autologous temporalis fascia.

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“…In fact, autologous materials are an excellent option for they are a natural tissue without additional costs for the patient: rectus muscle aponeurosis, tunica vaginalis, saphenous vein, fascia lata, and a variety of other autogenous materials. [32][33][34][35] Excision of plaque occurs it's if large or calcified. If not, incisions only are performed.…”

Section: Tunica Plication: Procedures That Shorten the Tunicamentioning

confidence: 99%

Recent surgical advances in Peyronie’s Disease

Gaspar¹,

Dias²,

Martins³

et al. 2016

Acta Med Port

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RESUMOIntrodução: A doença de Peyronie, uma doença fibrótica da túnica albuginea do pénis tem estado associada a encurtamento peniano e a algum grau de disfunção eréctil. Afeta a qualidade de vida do doente, levando a stress psicológico, mental e físico. A deformidade peniana perturba a vida sexual do doente, levando a episódios de depressão, disfunções sexuais e a ansiedade associada ao ato sexual. A etiologia da doença de Peyronie permanece por esclarecer. Material e Métodos: A pesquisa na literatura foi efetuada nas bases de dados da Medline, Embase e Cochrane no mês de Janeiro de 2015 no sentido de identificar artigos relacionados com a doença de Peyronie, nomeadamente o tratamento cirúrgico, técnicas, resultados bem como tratamentos complementares. Publicações que não envolvessem humanos não foram consideradas. Identificámos artigos originais, artigos de revisão e editoriais acerca do assunto em questão. Todos os artigos publicados na língua inglesa foram selecionados para screening. Os critérios de elegibilidade para inclusão envolveram a relevância associada ao tema. Resultados: Existe uma variedade de deformidades penianas associada com a doença de Peyronie que ainda não têm uma solução não cirúrgica que seja eficaz. Apresentamos uma atualização das técnicas cirúrgicas atuais bem como o algoritmo de tratamento associada a esta doença. Discussão: Todos os tratamentos cirúrgicos têm como objetivo a correção da curvatura, a preservação da função eréctil e do comprimento peniano, bem como o de minimizar a morbilidade. Conclusão: Até à data não existem estudos de medicina baseada na evidência que determinem o melhor tratamento cirúrgico para a doença de Peyronie. Após o diagnóstico, a reconstrução cirúrgica deve ter como objetivo um pénis funcional, com uma retificação da sua curvatura que permita o acto sexual. Palavras-chave: Induração Peniana; Pénis/cirurgia; Procedimentos Cirúrgicos Urológicos Masculinos; Prótese de Pénis. ABSTRACT Introduction:Peyronie's disease, a fibrotic disorder of the tunica albuginea of the penis, has been associated with penile shortening and some degree of erectile dysfunction. It affects patient's quality of life, leading to severe psychological, mental, and physical stress. Penile deformation hampers sexual life leading to depression, lack of sexual confidence, loss of sexual function and performance anxiety. Peyronie's disease etiology is yet to be known. Material and Methods: Literature search was conducted in Medline, Embase, and Cochrane databases in January 2015 in order to identify papers related to Peyronie's disease, concerning evolving surgical management, technique, outcomes as well as ancillary treatments. Publications not concerning humans were not considered. We identified original articles, review articles, and editorials addressing the subject. All articles published in the English language were selected for screening. The eligibility criteria for inclusion were based on relevance concerning the subject. Results:The variety of penile deformities associated with P...

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A Comparison of Dermal and Cadaveric Pericardial Grafts in the Modified Horton-Devine Procedure for Peyronie’s Disease

Cited by 89 publications

References 31 publications

Surgery for Peyronie's disease

Surgery for Peyronie's disease

Inclusion cyst and graft contraction in Tutoplast human cadeveric pericardium following Peyronie's grafting: a previously unreported complication

Recent surgical advances in Peyronie’s Disease

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