A comparison of cystatin C- and creatinine-based prediction equations for the estimation of glomerular filtration rate in black South Africans

Abstract

In this study, S-Cys C-based prediction equations appear to be more precise than those of S-Cr for those patients with mGFR > 60 mL/min/1.73 m(2) and may therefore be of benefit in the earlier detection of renal impairment.

Chronic kidney disease epidemiology collaboration-derived glomerular filtration rate performs better at detecting preclinical end-organ changes than alternative equations in black Africans

“…In this regard, eGFR determined from both CKD-EPI and MDRD equations showed an improved performance for the detection of LVH, and CKD-EPI-derived eGFR was the only eGFR to independently associate with an increased aortic PWV. Although the CKD-EPI equation for estimating GFR shows a greater accuracy and less bias for the measurement of GFR and is better at risk predicting [8][9][10][11][12] than preceding equations, the value of this more contemporary equation in black African populations is uncertain [5,7,[13][14][15]. Indeed, the CKD-EPI equation does not perform as well in African as it does in white populations [5,13].…”

“…lww.com/HJH/A609). The ethnicity factor as recommended in African Americans when calculating the MDRD and CKD-EPI was not applied in the present study as the use results in overestimation of kidney function in black Africans in the present region [14].…”

“…In addition, the CKD-EPI equation more accurately categorizes individuals regarding clinical risk [8][9][10][11][12] than the Modification of Diet in Renal Disease (MDRD) study equation, the equation predating the CKD-EPI equation. However, because the relationship between creatinine and GFR varies between ethnicities, neither the MDRD, nor the CKD-EPI equations perform as well in African as they do in white populations [5,13], and the use of an ethnicity coefficient may not improve on performance in some African populations [7,14,15]. However, there are no studies that have compared the relations between the multiple equations available for estimating GFR and either cardiovascular outcomes or preclinical cardiovascular damage in black African communities.…”

Serum Cystatin C is Associated with Renal Function Recovery in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

“…This is probably due to the fact that sCyC is an early biomarker of renal injury, while the increase in sCr lags far behind the renal injury and does not increase until more than 70% of renal function has been lost [8]. Furthermore, in contrast to sCr, which can be influenced by age, muscle mass, gender, race and hydration status, CyC is independent of these confounding factors [25,26]. This is another explanation for the better performance of CyC in predicting renal recovery.…”

Increased Time Exposure to Tenofovir Is Associated with a Greater Decrease in Estimated Glomerular Filtration Rate in HIV Patients with Kidney Function of Less than 60 ml/min/1.73 m²

“…Recent studies on eGFR performance in HIV patients showed that CKD-EPI and MDRD were similar for an eGFR below 60 ml/min/1.73 m 2 [46] and that sensitivity analysis using CKD-EPI provided similar results. Moreover, other studies have shown that the use of creatinine-based equations for CKD diagnosis can lead to missclassification, with the risk of overdiagnosis of CKD [47,48,49]. We also analyzed acute kidney injury episodes during follow-up and found that this did not modify the final association.…”