Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. se. TASK NUMBER 5f. WORK UNIT NUMBER
REPORT DATE
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERStanford University Stanford, CA 94305-5401
SPONSORING I MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012
SPONSORIMONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACTWith the development of computer controlled MLC, IMRT now provides unprecedented means to deliver 3D-dose distributions with sub-centimeter resolution. Inverse planning is at the foundation of IMRT and critically determines its success. As practiced now, however, the capacity of IMRT is greatly underutilized because of the inferior performance of the inverse planning systems. Because of the tacit ignorance of intra-structural tradeoff, the IMRT plans generated by these systems for prostate treatment are, at best, sub-optimal and our endeavor of providing the best possible patient care is compromised. We have carried out a systematic study on this unexplored issue and developed innovative techniques to improve prostate IMRT. A number of important milestones have been accomplished, which include (i) established a theoretical infrastructure of spatially non-uniform penalty scheme for inverse planning; (ii) developed method for incorporating existing clinical knowledge into inverse planning; (iii) proposed an electron density mapping technique to improve the quality of conebeam CT (CBCT) images; (iv) established a robust technique for using onboard CBCT for on-treatment IMRT dose validation; (v) improved prostate IMRT beam orientation selection by integrating organ specific EUD. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of prostate IMRT.
IS. SUBJECT
II.RESEARCH AND ACCOMPLISHMENTSThe success of prostate Intensity modulated radiation therapy (IMRT) depends critically on the performance of inverse planning system. As it is practiced now, however, the capacity of I...