A Comparison of Chlorpromazine and EST in Treatment of Acute Schizophrenic and Manic Reactions

Langsley, Donald G.; Enterline, J. D.; Hickerson, George X.

doi:10.1001/archneurpsyc.1959.02340150116015

Cited by 42 publications

(15 citation statements)

References 5 publications

(3 reference statements)

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“…In 1959, Langsley et al published results of the one early randomized controlled trial, which involved 106 patients with mania or schizophrenia. In this study, ECT produced results that were equivalent to chlorpromazine; however, results for the two diagnoses were not reported separately 58. Mukherjee et al discussed six retrospective studies done since 1976 54.…”

Section: Overview Of Efficacy Researchmentioning

confidence: 66%

Electroconvulsive Therapy: Part I. A Perspective on the Evolution and Current Practice of ECT

Payne

Prudic²

2009

Journal of Psychiatric Practice

145

147

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The concept of inducing convulsions, mainly through chemical means, to promote mental wellness has existed since the 16th century. In 1938, Italian scientists first applied electrically induced therapeutic seizures. Although electroconvulsive therapy (ECT) is employed in the treatment of several psychiatric disorders, it is most frequently used today to treat severe depressive episodes and remains the most effective treatment available for those disorders. Despite this, ECT continues to be the most stigmatized treatment available in psychiatry, resulting in restrictions on and reduced accessibility to a helpful and potentially life-saving treatment. The psychiatric and psychosocial ramifications of this stigmatization may include the exacerbation of the increasingly serious, global health problem of major depressive disorders as well as serious consequences for individual patients who may not be offered, or may refuse, a potentially beneficial treatment. The goal of this first article in this two-part series is to provide an overview of ECT's historical development and discuss the current state of knowledge about ECT, including technical aspects of delivery, patient selection, its side-effect profile, and factors that may contribute to underuse of ECT.

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Section: Overview Of Efficacy Researchmentioning

confidence: 66%

Electroconvulsive Therapy: Part I. A Perspective on the Evolution and Current Practice of ECT

Payne

Prudic²

2009

Journal of Psychiatric Practice

145

147

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“…However, the introduction of chlorpromazine in the 1950s and continued successful development of new pharmacological agents since led to a considerable decline in the utilization of ECT, particularly in the United States and Europe [4]. This decline can predominantly attributed to the convenience and better social acceptance of pharmacologic treatment, and the results of early studies suggesting that antipsychotics have comparable efficacy to ECT [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Electroconvulsive Therapy and Schizophrenia: A Systematic Review

Ali¹,

Mathur²,

Malhotra³

et al. 2019

Complex Psychiatry

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Electroconvulsive therapy (ECT) is a remarkably effective treatment for major depressive disorder, but is less commonly utilized for treatment of psychotic disorders. Recent literature indicates that ECT can be a useful strategy for a wide range of psychotic disorders, including treatment-resistant schizophrenia. The purpose of this review is to examine the extant literature on ECT in schizophrenia with a primary focus on its efficacy, its impact on cognitive function, the role of maintenance ECT, and the potential role of neuroimaging biomarkers to provide more precise ECT treatment strategies. We evaluated the available literature, with a particular focus on prospective, randomized trials. Our review suggests that ECT can be an effective treatment strategy in this severely ill patient population. Studies suggest that while ECT in schizophrenia is a safe treatment modality, the potential for cognitive impairment must always be carefully weighed. The use and investigation of new biomarker strategies for the pharmacological treatment of schizophrenia, and the extension of these approaches to ECT are also discussed.

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“…Thirteen of the 22 patients receiving ECT met strict criteria for remission lasting at least a week after the completion of ECT, while none of the pharmacotherapy group responded. One other earlier randomized controlled trial that compared ECT with chlorpromazine in patients with mania and schizophrenia found no difference in outcomes (Langsley et al 1959). However, as results were not reported separately for patients with mania and schizophrenia, it is difficult to draw any conclusions from this.…”

Section: Efficacy Relative To Other Treatmentsmentioning

confidence: 92%

Nonpharmacotherapeutic Somatic Treatments for Bipolar Disorder (ECT, DBS, rTMS)

Loo

Greenberg

Mitchell

2010

Behavioral Neurobiology of Bipolar Disorder and Its Treatment

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Nonpharmacotherapeutic, somatic treatments play an essential role in the management of bipolar disorder (BPD). Studies indicate that electroconvulsive therapy (ECT) is an effective treatment for acute mania, bipolar depression, and mixed affective states. Furthermore, it is an important second-line treatment option, as most pharmacotherapy-resistant patients respond to ECT. Specific challenges for patients with BPD receiving ECT include the risk of mood switching, and the need to evaluate and manage concurrent treatment with lithium and anticonvulsant mood stabilizers. Although the current evidence for alternative and newer physical treatments (e.g., transcranial magnetic stimulation, vagus nerve stimulation, stereotactic ablation, and deep brain stimulation) is preliminary, all of these novel methods show promising potential and merit further research.

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A Comparison of Chlorpromazine and EST in Treatment of Acute Schizophrenic and Manic Reactions

Cited by 42 publications

References 5 publications

Electroconvulsive Therapy: Part I. A Perspective on the Evolution and Current Practice of ECT

Electroconvulsive Therapy: Part I. A Perspective on the Evolution and Current Practice of ECT

Electroconvulsive Therapy and Schizophrenia: A Systematic Review

Nonpharmacotherapeutic Somatic Treatments for Bipolar Disorder (ECT, DBS, rTMS)

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